From marker to solution: personalized obstetric and gynecological care

This issue focuses on the translation of molecular and clinical-instrumental indicators into personalized solutions in obstetrics and gynaecology. In gynaecological oncology, the discussion covers integrated biomarkers of thrombotic risk (vWF/ADAMTS-13 axis, antiphospholipid antibodies) and the potential for organ-preserving interventions, including robot-assisted procedures. In reproductive medicine, the issues addressed include preconception care of deficiencies (e. g. iron and folate), assessment of the uterine cavity in older patients and predictors of adverse perinatal outcomes in cases of premature rupture of membranes. Reviews on the Wnt/β-catenin cascade in endometriosis, molecular genetic markers of breast cancer, and nanotechnology provide a foundation for developing diagnostic panels and targeted approaches. A clinical case study of vaginal reconstruction and a historical essay complement the practical and educational content of the issue.

1. Vorobev A.V., Bitsadze V.O., Solopova A.G., Khizroeva J.Kh., Utkin D.O., Ostrikov D.O., Blinov D.V., Gris J.-C., Elalami I., Gerotziafas G., Makatsariya A.D. Prognostic role of the vWF/ADAMTS-13 axis in thrombosis risk stratification in gynecologic oncology patients. [Prognostic role of the vWF/ADAMTS-13 axis in thrombosis risk stratification in gynecologic oncology patients]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):476–487. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.664.

2. Karpova A.L., Mostovoi A.V., Ponimanskaya M.A., Lee O.N., Desyatnik K.A., Martirosyan S.V., Kadyn S.N., Karpov N.Yu., Shichanina A.A., Kuznetsova A.S. Predictors of unfavorable perinatal outcomes in premature rupture of membranes. [Prediktory neblagopriyatnyh perinatal'nyh iskhodov pri prezhdevremennom razryve plodnyh obolochek]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):488–505. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.622.

3. Lokshin V.N., Rybina A.N., Abshekenova A.T., Askar E., Karibaeva Sh.K., Valiev R.K. The uterine cavity state in older reproductive age patients. [Sostoyanie polosti matki u pacientok starshego reproduktivnogo vozrasta]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):506–513. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.654.

4. Grigoreva K.N., Bitsadze V.O., Vorobev A.V., Solopova A.G., Khizroeva J. Kh., Iakubov A.Z., Ungiadze J.Yu., Kalashnikova I.S., Utkin D.O., Blinov D.V., Gris J.-C., Elalamy I., Gerotziafas G., Makatsariya A.D. On the issue of recurrent thrombosis in cancer patients. [K voprosu o recidiviruyushchih trombozah u onkologicheskih bol'nyh]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):514–523. (In Russ.). https:// doi.org/10.17749/2313-7347/ob.gyn.rep.2025.667.

5. Lukmanova L.Kh., Muslimova S.Yu., Sakhautdinova I.V. Lichen sclerosus epidemiology in girls of the Republic of Bashkortostan. [Epidemiologiya skleroziruyushchego lihena u devochek Respubliki Bashkortostan]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):524–533. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.573.

6. Virivskaya E.V., Ignatko I.V., Snimshchikova I.A., Bakhtiyarov K.R., Zueva A.S., Kapyrina T.D. Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis. [Rol' Wnt/β-kateninovogo signal'nogo puti v patogeneze endometrioza]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):534–544. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.640.

7. Khamadyanova A.U., Gaev T.T., Gatsoev D.O., Andreev V.V., Pazhitnova A.S., Tikhonova E.O., Kim V.G., Talalaeva D.A., Agapova V.V., Botina R.S., Yakovleva A.K., Vasileva S.D., Bakulin D.Yu. Minimally invasive and robot-assisted interventions in the treatment of gynecological malignant tumors: opportunities for preserving reproductive function. [Minimal'no invazivnye i robot-assistirovannye vmeshatel'stva v lechenii ginekologicheskih zlokachestvennyh opuholej: vozmozhnosti sohraneniya reproduktivnoj funkcii]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):545–560. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.628.

8. Kuvaev V.S., Kazenashev V.V., Derevyanko O.S., Tikhomirov A.L., Garaeva L.R., Davydenko N.L., Maminova M.V., Lyapina K.V., Rurua N.V. The importance of iron deficiency and folic acid deficiency prevention upon pregnancy planning. [Znachenie deficita zheleza i profilaktiki deficita folievoj kisloty pri planirovanii beremennosti]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):561–573. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.672.

9. Omarov M.M., Trusova V.V., Agabekyan L.M., Gaziev I.R., Alibekova Z.M., Aivazyan L.A., Safarova E.A., Adzhigulova A.M., Darmilova A.A., Khanmukhometova E.K., Vanova I.R., Pigareva V.I. Molecular genetic markers of breast cancer: current advances in understanding the etiology, prognostic value, and therapeutic opportunities. [Molekulyarno-geneticheskie markery raka molochnoj zhelezy: sovremennye dostizheniya v ponimanii etiologii, prognosticheskoj cennosti i terapevticheskih vozmozhnostej]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):575–589. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.631.

10. Faizullina Z.R., Zhilenko A.A., Islamgulov A.Kh., Chernaya E.A., Tochieva A.I., Sanova A.A., Dryaeva D.A., Khaknazarov S.Sh., Gazizov T.R., Otadzhonov M.M., Merzhoeva Kh.A., Malikova E.V., Glazepa V.A., Matviets A.K. The role of nanotechnologies in diagnostics and treatment of female reproductive system cancer. [Rol' nanotekhnologij v diagnostike i lechenii zlokachestvennyh novoobrazovanij zhenskoj reproduktivnoj sistemy]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):590–607. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.617.

11. Yashchuk A.G., Gubanova E.G., Musin I.I., Battalova G.Yu., Urmantsev M.F. Treatment of secondary vaginal atresia with the Martius-Symmonds flap. [Lechenie vtorichnoj atrezii vlagalishcha s pomoshch'yu loskuta Martius-Symmonds]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):608–613. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.614.

12. Zhuravleva E.M., Vorobev A.V., Makatsariya N.A. Franсois Morisot and the birth of obstetrics. [Fransua Moriso i rozhdenie akusherskoj nauki]. Obstetrics, Gynecology, and Reproduction. 2025;19(4):614–618. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.665.