Preview

Obstetrics, Gynecology and Reproduction

Advanced search

Systematic analysis of research on D-mannose and the prospects for its use in recurrent infections of the urinary tract in women of reproductive age

https://doi.org/10.17749/2313-7347.2019.13.2.119-131

Full Text:

Abstract

Cystitis and other urinary tract infections (UTIs) in women of reproductive age can lead to infertility, significantly complicate the course of pregnancy, and cause numerous fetal abnormalities. Antibiotic therapy during pregnancy is an extreme measure since it is associated with a high risk of fetal malformations. The use of D-mannose is an effective and safe treatment for cystitis and other UTIs, especially during pregnancy. The present systematic analysis of 32111 studies indicates a significance of D-mannose for glycosylation of human proteins and for functioning of the immune, cardiovascular, urinary and other systems. By blocking the interaction between bacterial fimbriae and the endothelium, D-mannose prevents the adsorption of bacteria (uropathogenic strains of Escherichia coli, Pseudomonas aeruginosa, Shigella, leishmania, mycobacteria, etc.) to the tissue surface, thus helping prevent recurrent UTIs. Clinical studies have confirmed both high efficacy and safety of using D-mannose and the synergistic substances (such as cranberry anthocyanins) for the treatment of cystitis and other UTIs.

About the Authors

O. A. Gromova
http://pharmacoinformatics.ru
Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation

Olga A. Gromova – MD, PhD, Professor, Leading Researcher, Scientific Director

Leading Researcher

Scopus Author ID: 7003589812

Author ID: 94901

РИНЦ SPIN-код: 6317-9833

WOS ID: J-4946-2017



I. Yu. Torshin
Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation

Ivan Yu. Torshin – PhD (Chemistry), Senior Researcher

Senior Researcher

Author ID: 54104 

Scopus Author ID: 7003300274 

РИНЦ SPIN-код: 1375-1114 

WOS ID: C-7683-2018



N. K. Tetruashvili
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Health Ministry of Russian Federation
Russian Federation

Nana K. Tetruashvili – MD, PhD, Professor, Head of Obstetric Department of Pregnancy Pathology № 2



References

1. Caron F., Galperine T., Flateau C. et al. Practice guidelines for the management of adult community-acquired urinary tract infections. Med Mal Infect. 2018;48(5):327–58. DOI: 10.1016/j. medmal.2018.03.005. PMID: 29759852.

2. Ghouri F., Hollywood A., Ryan K. A systematic review of non-antibiotic measures for the prevention of urinary tract infections in pregnancy. BMC Pregnancy Childbirth. 2018;18(1):99. DOI: 10.1186/s12884-018-1732-2. PMID: 29653573.

3. Gregory D.S., Wu V., Tuladhar P. The pregnant patient: managing common acute medical problems. Am Fam Physician. 2018;98(9):595–602. PMID: 30325641.

4. Medus M.L., Gomez G.E., Zacchi L.F. et al. N-glycosylation triggers a dual selection pressure in eukaryotic secretory proteins. Sci Rep. 2017;7(1):8788. DOI: 10.1038/s41598-017-09173-6. PMID: 28821844.

5. Maverakis E., Kim K., Shimoda M. et al. Glycans in the immune system and the altered glycan theory of autoimmunity: a critical review. J Autoimmun. 2015;57:1–13. DOI: 10.1016/j.jaut.2014.12.002. PMID: 25578468.

6. Rushforth K. Trees of Britain and Europe (Collins Wild Guide). Harpercollins Pub Ltd, 1999. 1336 p.

7. Postma P.W., Lengeler J.W., Jacobson G.R. Phosphoenolpyruvate: carbohydrate phosphotransferase systems of bacteria. Microbiol Rev. 1993;57(3):543–94. PMID: 8246840.

8. Torshin I.Yu., Rudakov K.V. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 1: factorization approach. Pattern Recognition and Image Analysis: Advances in Mathematical Theory and Applications. 2017;27(1):16–28.

9. Torshin I.Yu., Rudakov K.V. On the theoretical basis of metric analysis of poorly formalized problems of recognition and classification. Pattern Recognition and Image Analysis: Advances in Mathematical Theory and Applications. 2015;25(4):577–87.

10. Torshin I.Yu., Rudakov K.V. On metric spaces arising during formalization of problems of recognition and classification. Part 1: properties of compactness. Pattern Recognition and Image Analysis: Advances in Mathematical Theory and Applications. 2016;26(2):274–84.

11. Torshin I.Yu., Rudakov K.V. On metric spaces arising during formalization of problems of recognition and classification. Part 2: density properties. Pattern Recognition and Image Analysis: Advances in Mathematical Theory and Applications. 2016;26(3):483–96.

12. Torshin I.Yu., Gusev E.I., Gromova O.A. et al. International experience in studying effects of omega-3 polyunsaturated fatty acids: the influence on cognitive abilities and some mental disorders. [Mirovoj opyt izucheniya effektov omega-3 polinenasyshchennyh zhirnyh kislot: vliyanie na kognitivnyj potencial i nekotorye psihicheskie rasstrojstva]. Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. 2011;111(11):79–86. (In Russ.). PMID: 22611686.

13. Gromova O.A., Torshin I.Yu., Kalacheva A.G. et al. The perspective lines of using standardized forms of omega-3 polyunsaturated fatty acids in neurology. [Perspektivy ispol'zovaniya standartizirovannyh form omega-3 polinenasyshchennyh zhirnyh kislot v nevrologii]. Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. 2012;112(1):101–5. (In Russ.). PMID: 22701885.

14. Torshin I.Yu., Rudakov K.V. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis: Advances in Mathematical Theory and Applications. 2017;27(2):184–99.

15. Kondrashova M.N., Doliba N.M. Polarographic observation of substrate-level phosphorylation and its stimulation by acetylcholine. FEBS Letters. 1989;243(2):153–5. PMID: 2917643.

16. Vlahopoulos S., Gritzapis A.D., Perez S.A. et al. Mannose addition by yeast Pichia Pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody herceptin. Vaccine. 2009;27(34):4704–8. DOI: 10.1016/j.vaccine.2009.05.063. PMID: 19520203.

17. Lee S.J., Evers S., Roeder D. et al. Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science. 2002;295(5561):1898–901. DOI: 10.1126/science.1069540. PMID: 11884756.

18. Szolnoky G., Bata-Csorgo Z., Kenderessy A.S. et al. A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans. J Invest Dermatol. 2001;117(2):205–13. DOI: 10.1046/j.1523-1747.2001.14071.x. PMID: 11511295.

19. Gazi U., Martinez-Pomares L. Influence of the mannose receptor in host immune responses. Immunobiology. 2009;214(7):554–61. DOI: 10.1016/j.imbio.2008.11.004. PMID: 19162368.

20. Armelle J. Recurrent cystisis: No medicine preventive means. Prog Urol. 2017;27(14):823–30. DOI: 10.1016/j.purol.2017.09.006. PMID: 29033364.

21. Eden C.S., Hagberg L., Hanson L.A. et al. Adhesion of Escherichia coli in urinary tract infection. Ciba Found Symp. 1981;80:161–87. PMID: 6114819.

22. Tabasi M., Asadi Karam M.R., Habibi M. et al. Phenotypic assays to determine virulence factors of uropathogenic Escherichia coli (UPEC) isolates and their correlation with antibiotic resistance pattern. Osong Public Health Res Perspect. 2015;6(4):261–8. DOI: 10.1016/j.phrp.2015.08.002. PMID: 26473094.

23. Schaeffer A.J., Chmiel J.S., Duncan J.L., Falkowski W.S. Mannose-sensitive adherence of Escherichia coli to epithelial cells from women with recurrent urinary tract infections. J Urol. 1984;131(5):906–10. PMID: 6142969.

24. Agata N., Ohta M., Miyazawa H. et al. Serological response to P-fimbriae of Escherichia coli in patients with urinary tract infections. Eur J Clin Microbiol Infect Dis. 1989;8(2):156–9. PMID: 2566483.

25. Cordeiro M.A., Werle C.H., Milanez G.P., Yano T. Curli fimbria: an Escherichia coli adhesin associated with human cystitis. Braz J Microbiol. 2016;47(2):414–6. DOI: 10.1016/j.bjm.2016.01.024. PMID: 26991275.

26. Nowicki B., Svanborg-Eden C., Hull R., Hull S. Molecular analysis and epidemiology of the Dr hemagglutinin of uropathogenic Escherichia coli. Infect Immun. 1989;57(2):446–51. PMID: 2643568.

27. Johnson J.R. Virulence factors in Escherichia coli urinary tract infection. Clin Microbiol Rev. 1991;4(1):80–128. PMID: 1672263.

28. Monard A., Benoit G., Jacques L., Jardin A. Frequency of adherent colibacillus in a population with acute pyelonephritis and a population with acute cystitis. Prog Urol. 1993;3(4):583–9. PMID: 8104638.

29. Terai A., Yamamoto S., Mitsumori K. et al. Escherichia coli virulence factors and serotypes in acute bacterial prostatitis. Int J Urol. 1997;4(3):289–94. PMID: 9255669.

30. Domingue G.J., Roberts J.A., Laucirica R. et al. Pathogenic significance of P-fimbriated Escherichia coli in urinary tract infections. J Urol. 1985;133(6):983–9. PMID: 2860251.

31. Wellens A., Garofalo C., Nguyen H. et al. Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex. PLoS One. 2008;3(4):e2040. DOI: 10.1371/journal.pone.0002040. PMID: 18446213.

32. Subramanian P., Barka-Bouaifel F., Bouckaert J. et al. Graphene-coated surface plasmon resonance interfaces for studying the interactions between bacteria and surfaces. ACS Appl Mater Interfaces. 2014;6(8):5422–31. DOI: 10.1021/am405541z. PMID: 24433135.

33. Toyota S., Fukushi Y., Katoh S. et al. Anti-bacterial defense mechanism of the urinary bladder. Role of mannose in urine. Nihon Hinyokika Gakkai Zasshi. 1989;80(12):1816–23. PMID: 2576290.

34. Domenici L., Monti M., Bracchi C. et al. D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci. 2016;20(13):2920–5. PMID: 27424995.

35. Kranjcec B., Papes D., Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014;32(1):79–84. DOI: 10.1007/s00345-013-1091-6. PMID: 23633128.

36. Marchiori D., Zanello P.P. Efficacy of N-acetylcysteine, D-mannose and Morinda citrifolia to treat recurrent cystitis in breast cancer survivals. In Vivo. 2017;31(5):931–6. DOI:10.21873/invivo.11149. PMID: 28882961.

37. Del Popolo G., Nelli F. Recurrent bacterial symptomatic cystitis: A pilot study on a new natural option for treatment. Arch Ital Urol Androl. 2018;90(2):101–3. DOI: 10.4081/aiua.2018.2.101. PMID: 29974728.

38. Howell A.B., Reed J.D., Krueger C.G. et al. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry. 2005;66(18):2281–91. DOI: 10.1016/j. phytochem.2005.05.022. PMID: 16055161.

39. De Leo V., Cappelli V., Massaro M.G. et al. Evaluation of the effects of a natural dietary supplement with cranberry, Noxamicina® and D-mannose in recurrent urinary infections in perimenopausal women. Minerva Ginecol. 2017;69(4):336–41. DOI: 10.23736/S0026- 4784.17.04074-6. PMID: 28608666.

40. Vicariotto F. Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study. J Clin Gastroenterol. 2014;48(Suppl 1):S96–101. DOI: 10.1097/MCG.0000000000000224. PMID: 25291140.

41. Fu Z., Liska D., Talan D., Chung M. Cranberry reduces the risk of urinary tract infection recurrence in otherwise healthy women: a systematic review and meta-analysis. J Nutr. 2017;147(12):2282–8. DOI: 10.3945/jn.117.254961. PMID: 29046404.


For citation:


Gromova O.A., Torshin I.Y., Tetruashvili N.K. Systematic analysis of research on D-mannose and the prospects for its use in recurrent infections of the urinary tract in women of reproductive age. Obstetrics, Gynecology and Reproduction. 2019;13(2):119-131. https://doi.org/10.17749/2313-7347.2019.13.2.119-131

Views: 22


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)