Systematic analysis of research on D-mannose and the prospects for its use in recurrent infections of the urinary tract in women of reproductive age
Abstract
Cystitis and other urinary tract infections (UTIs) in women of reproductive age can lead to infertility, significantly complicate the course of pregnancy, and cause numerous fetal abnormalities. Antibiotic therapy during pregnancy is an extreme measure since it is associated with a high risk of fetal malformations. The use of D-mannose is an effective and safe treatment for cystitis and other UTIs, especially during pregnancy. The present systematic analysis of 32111 studies indicates a significance of D-mannose for glycosylation of human proteins and for functioning of the immune, cardiovascular, urinary and other systems. By blocking the interaction between bacterial fimbriae and the endothelium, D-mannose prevents the adsorption of bacteria (uropathogenic strains of Escherichia coli, Pseudomonas aeruginosa, Shigella, leishmania, mycobacteria, etc.) to the tissue surface, thus helping prevent recurrent UTIs. Clinical studies have confirmed both high efficacy and safety of using D-mannose and the synergistic substances (such as cranberry anthocyanins) for the treatment of cystitis and other UTIs.
About the Authors
O. A. Gromova
http://pharmacoinformatics.ru
Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation
Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation
Olga A. Gromova – MD, PhD, Professor, Leading Researcher, Scientific Director
Leading Researcher
Scopus Author ID: 7003589812
Author ID: 94901
РИНЦ SPIN-код: 6317-9833
WOS ID: J-4946-2017
I. Yu. Torshin
Federal Research Center «Informatics and Management», Russian Academy of Sciences;
Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation
Russian Federation
Ivan Yu. Torshin – PhD (Chemistry), Senior Researcher
Senior Researcher
Author ID: 54104
Scopus Author ID: 7003300274
РИНЦ SPIN-код: 1375-1114
WOS ID: C-7683-2018
N. K. Tetruashvili
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Nana K. Tetruashvili – MD, PhD, Professor, Head of Obstetric Department of Pregnancy Pathology № 2
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Review
Supporting agencies: The study was supported by the Russian Foundation for Вasic Research, grants № 17-07-00935 и № 18-07-01022.
For citations:
Gromova O.A., Torshin I.Yu., Tetruashvili N.K. Systematic analysis of research on D-mannose and the prospects for its use in recurrent infections of the urinary tract in women of reproductive age. Obstetrics, Gynecology and Reproduction. 2019;13(2):119-131. https://doi.org/10.17749/2313-7347.2019.13.2.119-131
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