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Umbilical cord vascular thrombosis: literature review and two clinical cases

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.260

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Abstract

Thrombosis of the umbilical cord vessels is a rare complication of pregnancy, combined with a high level of perinatal morbidity and mortality. Among the risk factors for the development of thrombosis of the vessels of the umbilical cord are anomalies of vascular attachment (meningeal attachment), pathology of the umbilical cord (hyperspiralization, short or long umbilical cord), intrauterine infections, diabetes mellitus and preeclampsia in the mother, as well as the presence of meconium in the amniotic fluid. The article presents two clinical observations of umbilical vein thrombosis at full-term pregnancy. In both cases, during pregnancy and childbirth, there were no signs of umbilical cord pathology according to cardiotocography and Doppler, despite this, the birth of children in a state of hypoxia. Both newborns were transferred to the second stage of treatment due to suspected intrauterine pneumonia. Of the risk factors for thrombosis of the umbilical cord vessels in the above examples, it is possible to distinguish the sheathing of the umbilical cord vessels, intrauterine infections, in the second case, the presence of meconium in the amniotic fluid. During pregnancy, both patients underwent a clinically confirmed novel coronavirus infection (COVID-19) in the second trimester of gestation, and were also in contact with patients with COVID-19 in the third trimester of gestation. It is likely that endothelial damage caused by the new coronavirus SARS-CoV-2 was one of the risk factors for the development of umbilical vein thrombosis, but this issue requires further research.

About the Authors

E. Iu. Iupatov
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation; Kazan (Volga Region) Federal University
Russian Federation

Evgenii Iu. Iupatov – MD, PhD, Associate Professor, Head of the Department of Obstetrics and Gynecology; Associate Professor, Department of Surgery and Postgraduate Education, Institute of Fundamental Medicine and Biology
Scopus Author ID: 57201192778. 

36 Butlerova Str., Kazan 420015;
18 Kremlevskaya Str., Kazan 420008



T. E. Kurmanbaev
Kirov Military Medical Academy, Ministry of Defense of Russian Federation
Russian Federation

Timur E. Kurmanbaev – MD, PhD, Faculty Member, Department of Obstetrics and Gynecology 

6 Klinicheskaya Str., Saint Petersburg 194044



I. R. Galimova
Kazan (Volga Region) Federal University
Russian Federation

Ilmira R. Galimova – MD, PhD, Associate Professor, Deputy Chief Physician for Obstetric and Gynecological Care, Medical and Sanitary Unit 

18 Kremlevskaya Str., Kazan 420008



A. T. Khaertdinov
Kazan (Volga Region) Federal University
Russian Federation

Albert T. Khaertdinov – MD, PhD, Obstetrician-Gynecologist, Head of the Maternity Department, Medical and Sanitary Unit 

18 Kremlevskaya Str., Kazan 420008



R. R. Mukhametova
Kazan (Volga Region) Federal University
Russian Federation

Renata R. Mukhametova – MD, Obstetrician-Gynecologist, Obstetric Department, Medical and Sanitary Unit 

18 Kremlevskaya Str., Kazan 420008



A. L. Mirolyubov
Kazan (Volga Region) Federal University
Russian Federation

Alex L. Mirolyubov – MD, PhD, Obstetrician-Gynecologist, Obstetric Department, Medical and Sanitary Unit 

18 Kremlevskaya Str., Kazan 420008



D. N. Ablaeva
Kazan (Volga Region) Federal University
Russian Federation

Dina N. Ablaeva – MD, Obstetrician-Gynecologist, Obstetric Department, Medical and Sanitary Unit 

18 Kremlevskaya Str., Kazan 420008



A. M. Khromova
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation; Kazan (Volga Region) Federal University
Russian Federation

Alla M. Khromova – MD, PhD, Associate Professor, Department of Forensic Medicine; Associate Professor, Department of Preventive Medicine 

36 Butlerova Str., Kazan 420015;
18 Kremlevskaya Str., Kazan 420008



M. I. Timerzyanov
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation; Kazan (Volga Region) Federal University
Russian Federation

Marat I. Timerzyanov – MD, Dr Sci Med, Head of the Department of Forensic Medicine; Head of the Department of Preventive Medicine 

36 Butlerova Str., Kazan 420015;
18 Kremlevskaya Str., Kazan 420008



M. D. Leonova
Maternity Hospital № 13
Russian Federation

Margarita D. Leonova – MD, Obstetrician-Gynecologist, Head of the Maternity Department 

4 Kostromskaya Str., Saint Petersburg 191124



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Review

For citation:


Iupatov E.I., Kurmanbaev T.E., Galimova I.R., Khaertdinov A.T., Mukhametova R.R., Mirolyubov A.L., Ablaeva D.N., Khromova A.M., Timerzyanov M.I., Leonova M.D. Umbilical cord vascular thrombosis: literature review and two clinical cases. Obstetrics, Gynecology and Reproduction. 0;. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.260

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)