Preview

Obstetrics, Gynecology and Reproduction

Advanced search

Placental site trophoblastic tumor during pregnancy complicated by uterine rupture

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.122

Abstract

The placental site trophoblastic tumor is a rare highly malignant form of trophoblastic disease, which occurs in as few as 0.4-2.0 % of all trophoblastic tumors. Available publications describes not more than 200 clinical cases of this pathology often affecting patients of reproductive age, thereby underscoring special importance of its diagnostics and treatment. Here we describe the rare clinical case of spontaneous uterine rupture in pregnant woman at 26 weeks of gestation carrying placental site trophoblastic tumor, previously undescribed in research literature. The complexity of diagnosing such pathology that resulted in antenatal fetal death and hysterectomy is demonstrated.

About the Authors

A. N. Sulima
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University; Simferopol Clinical Maternity Hospital № 1
Russian Federation
Anna N. Sulima - MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatology № 1, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Republic of Crimea, Russia; Obstetrician-Gynecologist, Simferopol State Clinical Maternity Hospital № 1, Simferopol.
5/7 Lenin Boulevard, Simferopol, Republic of Crimea 295006; 8 Vorovskogo Str., Simferopol, Republic of Crimea 295017.


D. A. Beglitse
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University; Simferopol Clinical Maternity Hospital № 1
Russian Federation
Dmitriy A. Beglitse - MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatology № 1, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Republic of Crimea, Russia; Chief physician, Simferopol Clinical Maternity Hospital № 1.
5/7 Lenin Boulevard, Simferopol, Republic of Crimea 295006; 8 Vorovskogo Str., Simferopol, Republic of Crimea 295017.


A. A. Davydova
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University
Russian Federation
Aleksandra A. Davydova - MD, PhD, Associate Professor, Department of Pathological Anatomy with Sectional Course, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University.
5/7 Lenin Boulevard, Simferopol, Republic of Crimea 295006.


V. V. Voronaya
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University
Russian Federation
Viktoriya V. Voronaya - MD, PhD, Assistant, Department of Obstetrics, Gynecology and Perinatology № 1, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University.
5/7 Lenin Boulevard, Simferopol, Republic of Crimea 295006.


A. N. Rybalka
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University
Russian Federation
Anatoliy N. Rybalka - MD, Dr Sci Med, Professor, Academician of the Crimean Academy of Sciences, Department of Obstetrics, Gynecology and Perinatology № 1, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University.
5/7 Lenin Boulevard, Simferopol, Republic of Crimea 295006.


P. N. Baskakov
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University
Russian Federation

Petr N. Baskakov - MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatology № 1, S.I. Georgievsky Medical Academy, V. I. Vernadsky Crimean Federal University.
5/7 Lenin Boulevard, Simferopol, Republic of Crimea 295006.



References

1. Ajithkumar T.V., Abraham E.K., Rejnishkumar R., Minimole A.L. Placental site trophoblastic tumor. Obstet Gynecol Surv. 2003;58(7):484-8. https://doi.org/10.1097/01.OGX.0000077466.40895.32.

2. Bouquet de la Joliniere J., Khomsi F., Fadhlaoui A. et al. Placental site trophoblastic tumor: a case report and review of the literature. Front Surg. 2014;1:31. https://doi.org/10.3389/fsurg.2014.00031.

3. Bruner D.I., Pritchard A.M., Clarke J. Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. West J Emerg Med. 2013;14(5):444-7. HTTPS://DOI.ORG/10.5811/westjem.2013.4.15868.

4. Gueye M., Gueye M.D.N., Thiam O. et al. Choriocarcinoma with uterine rupture presenting as acute haemoperitoneum and shock. Int J Reprod Contracept Obstet Gynecol. 2017;6(3):1141-3. https://doi.org/10.18203/2320-1770.ijrcog20170603.

5. Martusova Yu.S., Chekalova M.A., Meshcheryakova L.A., Moroz E.A. Ultrasound of placental site trophoblastic tumor. [Opyt ul'trazvukovoj diagnostiki trofoblasticheskoj opuholi placentarnogo lozha]. Ul'trazvukovaya i funkcional'naya diagnostika. 2014;(4):42-9. (In Russ.).

6. Knyazev S.A., Orazmuradov A.A., Golikova T.P. et al. Rupture of a uterus: last, real, future. [Razryv matki: proshloe, nastoyashchee, budushchee]. Vestnik Rossijskogo universiteta druzhby narodov. Seriya: Medicina. 2012;(6):176-86. (In Russ.).

7. Al-Zirqi I., Stray-Pedersen B., Forsen L. et al. Uterine rupture: trends over 40 years. BJOG. 2016;123(5):780-7. https://doi.org/10.1111/1471-0528.13394.

8. Meshcheryakova L.A. Trophoblastic disease (clinical lecture). [Trofoblasticheskaya bolezn' (klinicheskaya lekciya)]. Onkoginekologiya. 2013;(4):10-9. (In Russ.).

9. Allen S.D., Lim A.K., Seckl M.J. et al. Radiology of gestational trophoblastic neoplasia. Clin Radiol. 2006;61(4):301-13. https://doi.org/10.1016/j.crad.2005.12.003.

10. Surina M.N., Fetisova T.I., Marochko T.Yu. et al. Maternal death due to placental site trophoblastic tumor. [Klinicheskij sluchaj materinskoj smertnosti v rezul'tate trofoblasticheskoj bolezni placentarnoj ploshchadki]. Fundamental'naya i klinicheskaya medicina. 2016;1(2):88-96. (In Russ.).

11. Hassadia A., Gillespie A., Tidy J. et al. Placental site trophoblastic tumour: clinical features and managemen. Gynecol Oncol. 2005;99(3):603-7. https://doi.org/10.1016/j.ygyno.2005.06.054.

12. Huang F., Zheng W., Liang Q., Yin T. Diagnosis and treatment of placental site trophoblastic tumor. Int J Clin Exp Pathol. 013;6(7):1448— 51.

13. Order of the Ministry of Health of the Russian Federation of November 1, 2012 No. 572n «On approval of the Procedure for the provision of medical care in the profile of “obstetrics and gynecology (except for the use of assisted reproductive technologies)”». [Prikaz Ministerstva zdravoohraneniya RF ot 1 noyabrya 2012 g. № 572n «Ob utverzhdenii Poryadka okazaniya medicinskoj pomoshchi po profilyu "akusherstvo i ginekologiya (za isklyucheniem ispol'zovaniya vspomogatel'nyh reproduktivnyh tekhnologij)"». Moskva, 2014. 348 s. (In Russ). Available at: https://opckursk.ru/upload/norm_documents/13.pdf. [Accessed: 20.02.2020].

14. Yuan F., Si Wei S.H., Chen J. Spontaneous rupture of the gravid uterus in a postmenopausal woman receiving fertility treatment. Cureus. 2019;11(7):e5132. https://doi.org/10.7759/cureus.5132.

15. Bujold E., Mehta S.H., Bujold C., Gauthier R.J. Interdelivery interval and uterine rupture. Am J Obstet Gynecol. 2002;187(5):1199-202. https://doi.org/10.1067/mob.2002.127138.


Review

For citations:


Sulima A.N., Beglitse D.A., Davydova A.A., Voronaya V.V., Rybalka A.N., Baskakov P.N. Placental site trophoblastic tumor during pregnancy complicated by uterine rupture. Obstetrics, Gynecology and Reproduction. 2020;14(5):667-673. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.122

Views: 920


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)