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ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY

https://doi.org/10.17749/2313-7347.2017.11.1.014-018

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Abstract

The aim was to study the renin-angiotensin-aldosterone system (RAAS), the level of leptin and kidney function in women with pre-eclampsia (PE) and alimentary obesity (AO).

Materials and methods. The levels of renin, angiotensin II, aldoste-rone, leptin, insulin, cortisol, β2-microglobulin, glomerular filtration rate were measured.

Results. We show that RAAS, along with a systemic inflammatory response, is a key factor in the development of pre-eclampsia and its progression. The increasing level of leptin has a direct damaging effect on the tubular system of the kidneys.

Conclusions. Stimulating the RAAS aggravates the inflammatory response and endothelial dysfunction in women with PE and AO. Elevated concen-trations of leptin in these women have a direct damaging impact on the kidney tubules.

About the Authors

A. N. Rymashevskii
Rostov state medical University
Russian Federation

MD, professor, Head of the Department of Obstetrics and Gynaecology №1 Rostov State Medical University, the Ministry of Health, Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022



S. S. Tumanyan
Rostov state medical University
Russian Federation

graduate student of obstetrics and gynecology №1 Rostov State Medical University, Ministry of Health of the Russian Federation. Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022



E. M. Frantsiyants
Rostov scientific research oncological Institute
Russian Federation

MD, professor, Head hormonal laboratory FGBU Rostov Cancer Research Institute of the Ministry of Health. Address: ul. 14th line, 63, Rostov-on-Don, Russia, 344037



S. V. Tumanyan
Rostov scientific research oncological Institute
Russian Federation

MD Professor, Department of Anesthesiology and Intensive Care, Rostov State Medical University, the Ministry of Health. Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022



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For citation:


Rymashevskii A.N., Tumanyan S.S., Frantsiyants E.M., Tumanyan S.V. ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY. Obstetrics, Gynecology and Reproduction. 2017;11(1):14-18. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.1.014-018

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)