Prediction, personalization, and an interdisciplinary approach in modern obstetrics and gynecology

The editorial article is devoted to the key research directions presented in the fourth issue of the journal for 2026. The materials of the issue reflect the development of contemporary obstetric and gynecological science toward personalized risk assessment, digital prediction, and interdisciplinary interpretation of clinical, laboratory, instrumental, molecular, genetic, and immunological data. Particular attention is paid to the prediction of pregnancy complications, including preeclampsia, placenta-associated complications after SARS-CoV-2 infection, cervical remodeling, and reproductive outcomes in assisted reproductive technology programs. The article also discusses surgical treatment of genital prolapse, correction of iron deficiency states in abnormal uterine bleeding, immune mechanisms of tumor progression, sexual rehabilitation after treatment for gynecologic cancer, hemostatic disorders in recurrent pregnancy loss, genetic and epigenetic aspects of polyendocrine metabolic ovarian syndrome, management of patients of advanced reproductive age, treatment of epilepsy in women of reproductive age, and pregnancy in autoimmune diseases. The need for critical assessment of prognostic models, novel biomarkers, and publication integrity is separately emphasized as an essential prerequisite for trust in contemporary scientific writing.

1. Aliyeva R.M. Situational-factors-driven recurrence rate of laparoscopic sacropexy in genital prolapse. Obstetrics, Gynecology and Reproduction. 2026;20(4):617–625. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.733.

2. Ganeeva A.V., Gabidullina R.I., Kapelyushnik P.L., Valeeva E.V. Clinical and genetic predictors of great obstetrical syndromes following SARS-CoV-2 infection: the role of somatic background and the VDR gene rs2228570 polymorphism. Obstetrics, Gynecology and Reproduction. 2026;20(4):626–635. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.809.

3. Ivshin A.A., Boldina Yu.S., Malyshev N.A. Comparative effectiveness of eight machine learning algorithms and the FMF competing risks model for first-trimester preeclampsia prediction: a multicenter cohort study with external validation. Obstetrics, Gynecology and Reproduction. 2026;20(4):636–668. (In Russ.). 2026;20(4):636–668. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.729.

4. Sokolova T.M., Makarov K.Yu., Kuleshov V.M., Kiseleva T.V., Yakimova A.V. Clinical efficacy of combination therapy with iron and folic acid in reproductive-age patients with abnormal uterine bleeding. Obstetrics, Gynecology and Reproduction. 2026;20(4):669–677. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.812.

5. Khalenko V.V., Pachuliia O.V., Kopteeva E.V., Budilovskaya O.V., Khusnutdinova T.A., Krysanova A.A., Shalepo K.V., Savicheva A.M., Bespalova O.N. Integrative model of cervical remodeling: associations between ultrasound, immune and microbiological markers. Obstetrics, Gynecology and Reproduction. 2026;20(4):679–689. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.759.

6. Samsudin I.S., Rachmawati A., Erfiandi F., Devi N. Association between sperm morphology and embryo cleavage rate in in vitro fertilization: a retrospective study. Obstetrics, Gynecology and Reproduction. 2026;20(4):690–696. (In English). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.754.

7. Khamadyanova A.U., Romanova A.I., Sklyar A.N., Yamilova A.P., Miranda Planas M.G., Galeeva G.D., Khakimov S.R., Yakubov A.A., Bikinyaev S.K., Mammaev Sh.M., Vardanyan A.A., Kantaeva P.A., Algirieva T.R. TIGIT immunosuppressive role in female reproductive system malignant neoplasms: from mechanism to therapy. Obstetrics, Gynecology and Reproduction. 2026;20(4):697–715. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.647.

8. Dadalyan G.V., Saakyan A.A., Adamova S.D., Alimkhanova Kh.Kh., Aidaeva B.A., Magomedova N.M., Kabdegalieva A.R., Besheeva R.A., Osmanov D.A., Ersmurzaeva I.Z., Khalisov I.A., Shafikova S.U., Yaralieva F.R., Gyulmagomedova F.R. Challenges and solutions in sexual health among women after treatment for malignant neoplasms of the female reproductive system. Obstetrics, Gynecology and Reproduction. 2026;20(4):716–735. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.643.

9. Karpova I.A., Platitsyn V.A., Pavlenko A.S., Mateykovich E.A., Polyakova V.A., Shevlyukova T.P., Kukarskaya I.I., Nekrasova M.R., Sozonov A.I. Personalized hemostasis correction in recurrent pregnancy loss: analysis of current data, clinical controversies, and prospects. Obstetrics, Gynecology and Reproduction. 2026;20(4):736–747. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.756.

10. Koval Yu.E., Kapyrina T.D., Ignatko I.V., Bakhtiyarov K.R., Gilmutdinova I.I., Virivskaya E.V. The role of genetic and epigenetic factors in developing polycystic ovary syndrome. Obstetrics, Gynecology and Reproduction. 2026;20(4):748–763. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.766.

11. Mufazalova A.A., Khakimov I.A., Dmitrieva A.A., Gataullin R.V., Artemyeva P.A., Gadelshina A.Z., Zaripova I.I., Ivanova E.V., Ishkieva A.I., Kamalova A.R., Latypova E.R., Tazitov D.E., Teregulov T.R., Farkhullina V.I., Kharisova A.F., Shaidullina R.R. Pregravid preparation, antenatal care, and prevention of obstetric complications in women of advanced reproductive age: a literature review. Obstetrics, Gynecology and Reproduction. 2026;20(4):764–777. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.791.

12. Sibirskaya E.V., Karachentsova I.V., Popov A.A., Popova A.A., Stepanishcheva K.K. Current view on epilepsy treatment in reproductive age women. Obstetrics, Gynecology and Reproduction. 2026;20(4):778–785. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.767.

13. Khizroeva J.Kh., Galuaeva K.M., Tretyakova M.V., Gukasyan E.A., Oskolkova A.R., Shatalova O.V., Safaryan E.A., Bitsadze V.O., Makatsariya N.A., Chitaeva K.Kh., J Gris J.-C., Elalamy I., Gerotziafas G., Van Dreden Р. Pregnancy in autoimmune diseases: from immunological tolerance to placenta-associated complications. Obstetrics, Gynecology and Reproduction. 2026;20(4):786–801. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.774.

14. Uzdenova D.M., Timofeeva E.A., Isaev D.M., Mestoeva Z.B., Evsikova E.R., Kuznetsova A.A., Zabelin N.V., Kovalenko Yu.V., Kuznetsov D.S., Bembeeva A.E., Monid K.A., Koleukho A.V., Gil U.M. Clinical significance and safety profile of antibody-drug conjugates in malignancies of the female reproductive system. Obstetrics, Gynecology and Reproduction. 2026;20(4):802–819. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.769.

15. Makatsariya A.D., Vorobev A.V. From clinical observation to digital prediction: research in contemporary obstetrics, gynecology, and reproduction. Obstetrics, Gynecology and Reproduction. 2026;20(3):402–408. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.786.

16. EXPRESSION OF CONCERN: Clinical significance and safety profile of antibody-drug conjugates in malignancies of the female reproductive system. Obstetrics, Gynecology and Reproduction. 2026;20(4):820–822. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.813.