FLUORESCENT DIAGNOSIS IN THE MONITORING OF SELF-ADMINISTERED HORMONAL THERAPY IN FEMALE PATIENTS WITH ENDOMETRIAL PRECANCER AND CANCER
Abstract
The results of a fluorescent diagnosis programme in the monitoring of self-administered hormonal therapy using Alasens (3% solution - 10 ml injected into the uterine cavity) have been analyzed in 53 female patients of reproductive age with endometrial precancer or cancer. The time of exposition to Alasens was 2 hours. The fluorescent diagnostic procedure was carried out in this patient cohort at different stages of therapy: oncological and rehabilitative, as well as at one year after discontinuation of hormonal therapy After comparing the fluorescent and morphological examination data, an early relapse or ongoing process was diagnosed in 9 (16,9%) out of 53 patients
About the Authors
O. V. Chulkova
Moscow Scientific-Research Institute of Oncology named after P.A. Gertsen
Russian Federation
Russian Federation
E. V. Filonenko
Moscow Scientific-Research Institute of Oncology named after P.A. Gertsen
Russian Federation
Russian Federation
L. G. Serova
Chair of Obstetrics and Gynaecology, Faculty of Medicine, Russian State Medical University named after N. I. Pirogov, Moscow
Russian Federation
Russian Federation
I. I. Makarova
Chair of Obstetrics and Gynaecology, Faculty for Continuous Training and Postgraduate Education of Physicians, First Moscow State Medical University named after I. M. Sechenov
Russian Federation
Russian Federation
References
1. Ашрафян Л.А., Харченко Н.В., Огрызкова В.Л. Современные принципы первичной и уточняющей диагностики рака эндометрия//Практическая онкология. -2004. -Т. 5. № 1. -С. 16-24.
2. Берштейн Л.М., Эпидемиология, патогенез и пути профилактики рака эндометрия: стабильность или эволюция?//Практическая онкология. 2004. Т. 5. № 1. С. 1-8.
3. Бохман Я.В.//Руководство по онкогинекологии. СПб.: Фолиант, 2002. -С. 56-58, 309-330.
4. Лукин В.В. Лапароскопическая флуоресцентная диагностика перитонеальной диссеминации злокачественных новообразований: Автореф. дис. М., 2010 г.
5. Новикова Е.Г., Чулкова О.В., Пронин С.М. Предрак и начальный рак эндометрия у женщин репродуктивного возраста. -М.: МИА, 2005. -131 с.
6. Чиссов В.И., Старинский В.В. Основные показатели состояния онкологической помощи населению Российской Федерации в 2009 г. -М., 2009.
7. Чиссов В.И., Соколов В.В., Филоненко Е.В. Флюоресцентная эндоскопия, спекирофотометрия в диагностике злокачественных опухолей основных локализаций/Российский биотерапевтический журнал. 2003 г. № 4. -Т. 2. -С. 45-56.
8. Чиссов В.И., Трахтенберг А.Х. Ошибки в клинической онкологии. М., 1993 г.
9. Fehr M.K., Wyss P., Tadir Y. Selective photosensitizer localization in the human endometrial afte intrauterine application of 5-aminolevulinic acid. Obstetrics Am J Obstet Gynecol 2003. Nov 175(5): 1253-9.
10. Lang K., Lehmann P., Bolsen K. Aminolevulinic acid pharmacological profile and clinical indication. Obstetrics Expert Opin Investig Drugs. 2001 Oct, 72(10): 829-37.
11. Nowis D, Makowski M, Legat M, Golab J. Direct tumor damage mechanisms of photodynamic therapy. Obstetrics Acta Biochim Pol. 2005, 52(2):339-52.
12. Golab J. Direct tumor damage mechanisms of photodynamic therapy. Obstetrics Acta Biochim Pol. 2005, 52(2): 339-52.
13. Wyss P., Haller U., Berns M.W. Accumulation of 5-aminolevulinic acid -induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cell. Obstetrics Biochim Biohys Res Commum. 2006, Jul 25, 224(3): 819-24
For citation:
Chulkova O.V., Filonenko E.V., Serova L.G., Makarova I.I. FLUORESCENT DIAGNOSIS IN THE MONITORING OF SELF-ADMINISTERED HORMONAL THERAPY IN FEMALE PATIENTS WITH ENDOMETRIAL PRECANCER AND CANCER. Obstetrics, Gynecology and Reproduction. 2011;5(4):35-39. (In Russ.)
Views: 156
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
