Primary sclerosing cholangitis (PSC) is autoimmune disease characterized by inflammation and sclerosis of the bile duct, which leads to the development of secondary biliary cirrhosis. Many women with primary sclerosing cholangitis are at reproductive age (mean age of onset is 40 years old, but the cases of the disease in other age groups were described). There is a risk of negative impact of primary sclerosing cholangitis in the mother (exacerbation PSC) and the fetus (intrauterine fetal hypoxia, premature birth), but overall prognosis for the mother and child is favorable (if pregnant does not have cirrhosis of the liver complications). Pregnant women with varicose veins of the esophagus have a high maternal mortality. Ursodeoxycholic acid is the drug of choice for the treatment of pruritus in pregnant women with primary sclerosing cholangitis

Bacterial vaginosis is a serious risk factor of postnatal infectious complications development. It was established that there were significantly fewer cases of fever, leukocytosis and uterine disorders development during postnatal period among women with bacterial vaginosis treated by metronidazole in a dose of 500 mg twice a day within 10 days, than among untreated women

Placental insufficiency (PI) is a major problem of modern perinatology. Chronic placental insufficiency (CPI) is observed in every third pregnant woman at high risk of perinatal pathology. Perinatal mortality reaches 60% in this group. We investigated the modern approaches to diagnosis, prevention and therapy of placental insufficiency, including during varicosity. We studied the efficacy of Phlebodia 600 in the combined therapy of patients with PI. Based on these findings we are recommend prevention of PI (by Phlebodia 600) for all pregnant women with varicose veins, on the basis of morphologically confirmed reduction of placentas compensatory reactions

The article presents the results of a prospective cohort study that investigated changes in principal components of the metabolic syndrome (MS) in women in the course of a pregnancy and an assessment of these components in the postnatal period. The presented study has demonstrated that the metabolic syndrome deteriorates the course of pregnancy. This condition is an indication for complex evaluation by physicians of various specialities, strict control of the metabolic profile, and early administration of renal protectors

The diagnosis and treatment of urinary incontinence in women remain an important urogynaecological problem that has still not been properly investigated. Complete urinary incontinence is observed in patients with genitourinary fistulae. Partial urinary incontinence means a urinary incontinence upon exertion or stress urinary incontinence, imperative and combined urinary incontinence. Numerous factors exist that play a role in the development of urinary incontinence. The anatomical-topographic specifics of the small pelvis structure, the common blood supply and innervation, and the close functional ties allow to view the small pelvis as an integral, multi-component, complicated system in which virtually any seemingly local alterations are transformed into dysfunctions and anatomical abnormalities of adjacent organs. Successful treatment of female patients with urinary incontinence can be warranted by qualified and comprehensive medical evaluation based on a close contact with the patient, adherence to state-of-the-art diagnostic algorithms, and correct, professional implementation of instrumental methods of clinical work-up

The results of a fluorescent diagnosis programme in the monitoring of self-administered hormonal therapy using Alasens (3% solution - 10 ml injected into the uterine cavity) have been analyzed in 53 female patients of reproductive age with endometrial precancer or cancer. The time of exposition to Alasens was 2 hours. The fluorescent diagnostic procedure was carried out in this patient cohort at different stages of therapy: oncological and rehabilitative, as well as at one year after discontinuation of hormonal therapy After comparing the fluorescent and morphological examination data, an early relapse or ongoing process was diagnosed in 9 (16,9%) out of 53 patients

The problem of increasing successful IVF cycles number is actual. Leading factors which impact implantation are chronic endometritis, benigh uterus tumors, somatic diseases (including autoimmune), thrombophylias. Correlation between thrombophylic conditions and unsuccessful ART cycles is widely discussed in literature. However possible mechanisms of thrombophylia influence on IVF cycles outcomes are still unclear. Patients with inherited thrombosis liability or with antiphospholipid syndrome are mostly unsuccessful. Elaboration of individual approach in IVF treatment is required for such patients before starting IVF treatment taking into account leading infertility factors in the particular case