EFFECTS OF PREGNANCY ON THE PROGRESSION OF METABOLIC SYNDROME COMPONENTS
Abstract
The article presents the results of a prospective cohort study that investigated changes in principal components of the metabolic syndrome (MS) in women in the course of a pregnancy and an assessment of these components in the postnatal period. The presented study has demonstrated that the metabolic syndrome deteriorates the course of pregnancy. This condition is an indication for complex evaluation by physicians of various specialities, strict control of the metabolic profile, and early administration of renal protectors
About the Authors
I. O. Makarov
State Budget-Funded Educational Establishment First Moscow State Medical University named after I. M. Sechenov of the Ministry of Health and Social Development of the Russian Federation, Moscow
Russian Federation
Chair of Obstetrics and Gynaecology, Faculty for Continuous Training and Postgraduate Education of Physicians
Russian Federation
Chair of Obstetrics and Gynaecology, Faculty for Continuous Training and Postgraduate Education of Physicians
E. M. Shilov
State Budget-Funded Educational Establishment First Moscow State Medical University named after I. M. Sechenov of the Ministry of Health and Social Development of the Russian Federation, Moscow
Russian Federation
Chair of Nephrology and Haemodialysis, Faculty for Continuous Training and Postgraduate Education of Physicians
Russian Federation
Chair of Nephrology and Haemodialysis, Faculty for Continuous Training and Postgraduate Education of Physicians
M. S. Novikova
State Budget-Funded Educational Establishment First Moscow State Medical University named after I. M. Sechenov of the Ministry of Health and Social Development of the Russian Federation, Moscow
Russian Federation
Chair of Endocrinology, Faculty for Continuous Training and Postgraduate Education of Physicians
Russian Federation
Chair of Endocrinology, Faculty for Continuous Training and Postgraduate Education of Physicians
E. I. Borovkova
State Budget-Funded Educational Establishment First Moscow State Medical University named after I. M. Sechenov of the Ministry of Health and Social Development of the Russian Federation, Moscow
Russian Federation
Chair of Obstetrics and Gynaecology, Faculty for Continuous Training and Postgraduate Education of Physicians
Russian Federation
Chair of Obstetrics and Gynaecology, Faculty for Continuous Training and Postgraduate Education of Physicians
References
1. Кутырина И.М. Методы исследования функционального состояния почек. В кн.: Нефрология; под ред. Тареевой И.Е. Москва. -2000. -5. С. 90-92.
2. Bellver J., Melo M.A., Bosch E. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril 2007; 88: 446.
3. Brizzi P., Tonolo G., Esposito F. Lipoprotein metabolism during normal pregnancy. Am J Obstet Gynecol 1999; 181: 430.
4. Calandra C., Abell D.A., Beischer N.A. Maternal obesity in pregnancy. Obstet Gynecol 1981; 57: 8.
5. Chen A., Feresu S.A., Fernandez C. Maternal obesity and the risk of infant death in the United States. Epidemiology 2009; 20: 74.
6. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med, 2002; 346: 393-403. 7. Dahlquist, G., Stattin, E.L., Rudberg, S. Urinary albumin excretion rate and glomerular filtration rate in the prediction of diabetic nephropathy; a long-term follow-up study of childhood onset type-1 diabetic patients. Nephrol Dial Transplant 2001; 16: 1382.
7. Ehrenberg H.M., Iams J.D. Maternal Obesity, Uterine Activity, and the Risk of Spontaneous Preterm Birth. Obstet Gynecol 2009; 113: 48.
8. Jackson A.A. Nutrients, growth, and the development of programmed metabolic function. Adv Exp Med Biol 2000; 478: 41.
9. K/DOQI Clinical Practice Guidelines and Clinical Practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis 2007; 49(Suppl 2): S17.
10. K-DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification. Kidney Disease Outcome Quality Initiative. Am J Kidney Dis. 2002; 39: 1-266 9. Mattix, H.J., Hsu Cy, C., Shaykevich, S., Curhan, G. Use of the albumin/creatinine ratio to detect microalbuminuria: Implications of sex and race. J Am Soc Nephrol 2002; 13: 1034.
11. Mann J.F., Gerstein H.C., Pogue J. et al. Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: The HOPE randomized trail. Ann Int Med 2001; 134: 629-636
12. Perkins, B.A., Ficociello, L.H., Ostrander, B.E., et al. Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes. J Am Soc Nephrol 2007; 18: 1353.
13. Porrini E., Bayaes B. et al. Hyperinsulinemia and Hyperfiltration in Renal Transplantation. 2009; 87; 2: 274-279.
14. Tomaszewski M., Charchar F.J., Maric C., McClure J., Crawford L., Grzeszczak W., Sattar N. Glomerular hyperfiltration: A new marker of metabolic risk. Kidney International 2007; 71: 816-821. 14. Weiss, J.L., Malone, F.D., Emig, D., et al. FASTER research Consortium. Obesity, obstetric complications and Cesarean delivery rate -a population -based screening study. Am J Obstet Gynecol 2004; 190: 1091.
15. Weiner D.E., Tighiouart H., Amin M.G., et al. Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies. J Am Soc Nephrol. 2004; 15: 1307-1315
Review
For citations:
Makarov I.O., Shilov E.M., Novikova M.S., Borovkova E.I. EFFECTS OF PREGNANCY ON THE PROGRESSION OF METABOLIC SYNDROME COMPONENTS. Obstetrics, Gynecology and Reproduction. 2011;5(4):20-26. (In Russ.)
Views:
529
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
