Recurrent severe preeclampsia and the risk of late cardiovascular complications
A. R. Oskolkova,
A. A. Krivulyak,
A. R. Komelkova,
V. O. Bitsadze,
J. Kh. Khizroeva,
A. G. Solopova,
O. N. Li,
M. V. Tretyakova,
D. V. Blinov,
J.-C. Gris,
I. Elalamy,
G. Gerotziafas,
A. D. Makatsariya https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.764
Abstract
Preeclampsia (PE) is not only an acute obstetric complication but also a significant factor in long-term cardiovascular risk. This article analyzes the pathogenetic mechanisms linking recurrent severe PE with the development of chronic arterial hypertension, coronary heart disease, stroke, and heart failure in the long-term. Particular attention is paid to the two-stage PE model, as well as the key role for immune-inflammatory responses, oxidative stress, and hemostatic disorders. Recurrent PE is shown to cause cumulative damage to the vascular bed, transforming acute inflammation into chronic cardiovascular pathology. Neutrophil extracellular traps collectively resulting in innate immune activation, hypercoagulability, and endothelial damage, play a central role in the pathogenesis. Current approaches to preventing recurrent PE such as aspirin, calcium supplements, and low-molecular-weight heparins are discussed.
About the Authors
A. R. Oskolkova
Sechenov University
Russian Federation
Russian Federation
Arina R. Oskolkova
8 bldg. 2, Trubetskaya Str., Moscow 119048
A. A. Krivulyak
Sechenov University
Russian Federation
Russian Federation
Alena A. Krivulyak
8 bldg. 2, Trubetskaya Str., Moscow 119048
A. R. Komelkova
Sechenov University
Russian Federation
Russian Federation
Anastasia R. Komelkova
8 bldg. 2, Trubetskaya Str., Moscow 119048
V. O. Bitsadze
Sechenov University
Russian Federation
Russian Federation
Victoria O. Bitsadze, MD, Dr Sci Med, Prof., Professor of RAS.
Scopus Author ID: 6506003478.
WoS ResearcherID: F-8409-2017.
8 bldg. 2, Trubetskaya Str., Moscow 119048
J. Kh. Khizroeva
Sechenov University
Russian Federation
Russian Federation
Jamilya Kh. Khizroeva, MD, Dr Sci Med, Prof.
Scopus Author ID: 57194547147.
WoS ResearcherID: F-8384-2017.
8 bldg. 2, Trubetskaya Str., Moscow 119048
A. G. Solopova
Sechenov University
Russian Federation
Russian Federation
Antonina G. Solopova, MD, Dr Sci Med, Prof.
Scopus Author ID: 6505479504.
WoS ResearcherID: Q-1385-2015.
8 bldg. 2, Trubetskaya Str., Moscow 119048
O. N. Li
Vorokhobov City Clinical Hospital No. 67, Moscow Healthcare Department
Russian Federation
Russian Federation
Ok N. Li, MD, PhD.
2/44, Salyama Adilya Str., Moscow 123423
M. V. Tretyakova
Sechenov University
Russian Federation
Russian Federation
Maria V. Tretyakova, MD, PhD.
8 bldg. 2, Trubetskaya Str., Moscow 119048
D. V. Blinov
Institute for Preventive and Social Medicine; Moscow Haass Medical – Social Institute; Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology, Federal Medical-Biological Agency
Russian Federation
Russian Federation
Dmitry V. Blinov, MD, Dr Sci Med.
Scopus Author ID: 6701744871.
WoS ResearcherID: E-8906-2017.
11–13/1 Lyalin Pereulok, Moscow 101000;
5 bldg. 1–1a, 2-ya Brestskaya Str., Moscow 123056;
6 bldg. 1, Rodnikovaya Str., Village Goluboe, Moscow region 141551
J.-C. Gris
Sechenov University; University of Montpellier
France
France
Jean-Christophe Gris, MD, Dr Sci Med, Prof., Foreign Member of RAS.
Scopus Author ID: 7005114260.
WoS ResearcherID: AAA-2923-2019.
8 bldg. 2, Trubetskaya Str., Moscow 119048, Russia;
163 Rue Auguste Broussonnet, Montpellier 34090, France
I. Elalamy
Sechenov University; Medicine Sorbonne University; Hospital Tenon
France
France
Ismail Elalamy, MD, Dr Sci Med, Prof., Foreign Member of RAS.
Scopus Author ID: 7003652413.
WoS ResearcherID: AAC-9695-2019.
8 bldg. 2, Trubetskaya Str., Moscow 119048, Russia;
12 Rue de la Faculté de Médecine, Paris 75006, France;
4 Rue de la Chine, Paris 75020, France
G. Gerotziafas
Sechenov University; Medicine Sorbonne University; Hospital Tenon
France
France
Grigoriоs Gerotziafas, MD, Dr Sci Med, Prof., Foreign Member of RAS.
8 bldg. 2, Trubetskaya Str., Moscow 119048, Russia;
12 Rue de la Faculté de Médecine, Paris 75006, France;
4 Rue de la Chine, Paris 75020, France
A. D. Makatsariya
Sechenov University
Russian Federation
Russian Federation
Alexander D. Makatsariya, MD, Dr Sci Med, Prof., Academician of RAS.
Scopus Author ID: 57222220144.
WoS ResearcherID: M-5660-2016.
8 bldg. 2, Trubetskaya Str., Moscow 119048
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For citations:
Oskolkova A.R., Krivulyak A.A., Komelkova A.R., Bitsadze V.O., Khizroeva J.Kh., Solopova A.G., Li O.N., Tretyakova M.V., Blinov D.V., Gris J., Elalamy I., Gerotziafas G., Makatsariya A.D. Recurrent severe preeclampsia and the risk of late cardiovascular complications. Obstetrics, Gynecology and Reproduction. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.764
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