Reproductive function preservation in women with cervical cancer: treatment strategy

Introduction. Cervical cancer (CC) is a leading cause of reproductive function loss and the most common oncological pathology of the female reproductive system. Modern treatment methods (surgical, radiation, chemotherapeutic) increase survival but often result in infertility. Therefore, the development of organ-preserving approaches that allow fertility preservation is relevant.

Aim: to analyze available publications assessing preservation of reproductive function after СС treatment, effectiveness of methods, and identify key success factors.

Materials and Methods. A systematic review was conducted in accordance with the PRISMA 2020 guidelines. The search for publications from 2000 to 2025 was performed in PubMed/MEDLINE, Cochrane Library, eLibrary.ru, and CyberLeninka databases. The selection process identified 45 publications that met the inclusion criteria: original research, systematic reviews, meta-analyses, and clinical cases describing fertility-sparing strategies providing data on oncological and reproductive outcomes.

Results. Modern organ-preserving methods, including various types of trachelectomy, conization, neoadjuvant chemotherapy, and assisted reproductive technologies, allow achieving oncological safety while preserving reproductive potential in selected patients with early-stage СС.

Conclusion. Modern organ-preserving approaches in СС treatment hold a promise in oncogynecology, enabling the combination of treatment radicality with the maintenance of reproductive capabilities.

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