Interdisciplinary fact-based practice: obstetrics, gynaecology and andrology – a common language of data and solutions

This issue focuses on developing a unified, interdisciplinary approach to obstetrics, gynaecology, andrology and reproductive medicine based on objective data. The aim is to move from making decisions based on experience to using targeted, guided strategies based on early biomarkers and standardized algorithms. The review highlights studies demonstrating a pragmatic approach to life-threatening obstetric conditions, such as the management of coagulopathy in postpartum haemorrhage with a focus on the timely administration of tranexamic acid and the appropriate replacement of fibrinogen. It also covers new methods for combating postpartum infection and the early sepsis prediction. In gynaecological practice, the importance of minimal technological improvements (e.g. local antibiotic therapy during laparoscopy) in improving reproductive outcomes is emphasized, as is the relevance of organ-preserving surgery. There is a particular focus on structuring diagnostic pathways in andrology for azoospermia and oligozoospermia, where integrating spermiological, hormonal, ultrasound and genetic data enables differentiation of pathogenesis and development of personalized treatment strategies ranging from drug therapy to assisted reproductive technologies. The article also discusses the progressive integration of molecular markers (e.g. nectin-4 and components of extracellular vesicles) into clinical practice for diagnosing and prognosing reproductive system cancers, emphasizing the need for standardized analysis methods. The discussion of patient management strategies for menopausal women takes an interdisciplinary approach, requiring collaboration between gynaecologists, endocrinologists and dentists, and emphasizing the importance of preliminary hormonal correction prior to dental implantation. Taken together, the materials provide a comprehensive picture of the contemporary transformation of clinical practice, based on evidence-driven interdisciplinary dialogue.

1. Burduli A.G., Tetruashvili N.K., Balmasova I.P., Donnikov A.E., Krasheninnikova R.V., Kalinina E.A. Clinical and immunological characteristics of women with infertility and/or a history of recurrent pregnancy loss. [Kliniko-immunologicheskaya harakteristika zhenshchin s besplodiem i privychnym vykidyshem v anamneze]. Obstetrics, Gynecology and Reproduction. 2025;19(6):836–848. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.697.

2. Gridasova O.S., Solopova A.G., Khizroeva J.Kh., Bitsadze V.O., Ivanov A.E., Galkin V.N., Makatsariya A.D. The role of C3 and C4 complement components in postmenopausal vulvovaginal atrophy with a different clinical history. [Rol' komponentov S3 i S4 sistemy komplementa pri vul'vovaginal'noj atrofii v postmenopauze s razlichnym klinicheskim anamnezom]. Obstetrics, Gynecology and Reproduction. 2025;19(6):849–859. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.708.

3. Ivanov N.V., Amandullaev K.Z., Yusupova Sh.K., Vykhodtsev S.V., Medvedeva E.V. Azoospermia: etiology, pathogenesis, prevalence of forms and algorithm for differential diagnostics. [Azoospermiya: etiologiya, patogenez, rasprostranennost' form i algoritm differencial'noj diagnostiki]. Obstetrics, Gynecology and Reproduction. 2025;19(6):860–874. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.679.

4. Barinov S.V., Lazareva O.V., Shifman E.M., Shkabarnya L.L., Tirskaya Yu.I., Kadtsyna T.V., Khoroshkin E.A., Blauman E.S., Chulovsky Yu.I. Infectious and inflammatory diseases of the postpartum period: new approaches to diagnosis and treatment, predicting the risk of septic complications. [Infekcionno-vospalitel'nye zabolevaniya poslerodovogo perioda: novye podhody k diagnostike i lecheniyu, prognozirovanie riska septicheskih oslozhnenij]. Obstetrics, Gynecology and Reproduction. 2025;19(6):875–889. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.595.

5. Ivanov N.V., Amandullaev K.Z., Yusupova Sh.K., Vykhodtsev S.V., Medvedeva E.V. Oligozoospermia: etiology, pathogenesis, and algorithm for differential diagnostics. [Oligozoospermiya: etiologiya, patogenez i algoritm differencial'noj diagnostiki]. Obstetrics, Gynecology and Reproduction. 2025;19(6):890–903. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.680.

6. Romanovskaya A.V., Arzhaeva I.A., Mikhailovskaya T.V., Parshin A.V. Video endoscopic technologies in treatment of pelvic inflammatory diseases. [Primenenie videoendoskopicheskih tekhnologij v lechenii vospalitel'nyh zabolevanij organov malogo taza]. Obstetrics, Gynecology and Reproduction. 2025;19(6):904–913. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.645.

7. Correa-Pérez L., Olaya-Garay S, Mora-Martínez S. Management of coagulopathy related to major obstetric bleeding: narrative review. [Lechenie koagulopatii, svyazannoj s bol'shim akusherskim krovotecheniem: opisatel'nyj obzor]. Obstetrics, Gynecology and Reproduction. 2025;19(6):914–922. (In English). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.482.

8. Romanov E.G., Kokurina K.A., Fedotova A.A., Massolu Zh.E.A.K., Andreeva A.I., Khristoforova T.S., Ivanova R.A., Tarasova K.V., Ivanov M.A., Klyukina A.E., Sharafan M.A., M.A. Medvedko M.A., Modenova M.P. Nectin-4 significance in malignant neoplasms of the female reproductive system: a review of current data. [Znachenie nektina-4 pri zlokachestvennyh novoobrazovaniyah zhenskoj reproduktivnoj sistemy: obzor sovremennyh dannyh]. Obstetrics, Gynecology and Reproduction. 2025;19(5):923–941. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.634.

9. Sherbacheva A.O., Sibirtsev D.M., Savin N.N., Rumyantseva Ya.V., Brazhkina A.E., Kachalova V.M., Mamay A.V., Tipteva D.D., Khitrina Yu.V., Zhukov N.G., Izotov R.A., Yuldasheva E.R., Anokhina Ya.A. Extracellular vesicles in diagnostics and prognosis of malignant neoplasms of the female reproductive system: current data and future perspectives. [Vnekletochnye vezikuly v diagnostike i prognozirovanii zlokachestvennyh novoobrazovanij zhenskoj reproduktivnoj sistemy: sovremennye dannye i perspektivy]. Obstetrics, Gynecology and Reproduction. 2025;19(6):942–965. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.641.

10. Medvedeva E.V., Ivanov N.V., Vesnina A.F., Khromova E.A., Yusupova Sh.K. Menopause, postmenopausal osteoporosis, and dental implantation: the role of menopausal hormone therapy. [Menopauza, postmenopauzal'nyj osteoporoz i dental'naya implantaciya: rol' menopauzal'noj gormonal'noj terapii]. Obstetrics, Gynecology and Reproduction. 2025;19(6):966–975. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.678.

11. Kalaytanov M.V., Vavilov A.S., Maminova M.V., Yatsyk S.P., Poddubny I.V., Sytkov V.V., Tikhomirov A.L., Kazenashev V.V. A teenage girl with giant multilocular mucinous ovarian cystadenoma complicated by right-sided hydronephrosis: a case report. [Gigantskaya mnogokamernaya mucinoznaya cistadenoma yaichnika u devochkipodrostka, oslozhnennaya pravostoronnim gidronefrozom: klinicheskij sluchaj]. Obstetrics, Gynecology and Reproduction. 2025;19(6):976–986. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.638.

12. Makatsariya A.D. The image of mother and child in Byzantine and Russian iconography. [Obraz materi i rebenka v vizantijskoj i russkoj ikonopisi]. Obstetrics, Gynecology and Reproduction. 2025;19(6):987–995. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.704.