Congenital human herpesvirus 6 infection in a full-term newborn: literature review and case report
A. L. Karpova,
A. V. Mostovoi,
A. A. Baranov,
L. A. Anikeeva,
E. V. Klubnichkina,
A. L. Zaplatnikov,
L. N. Karpov https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.635
Abstract
Neonatal human herpesvirus type 6 (HHV-6) infection is an extremely rare disease. HHV-6 is a unique virus because it is able to integrate into human chromosomes to be further transmitted vertically from parent to offspring. In humans, HHV-6 is associated with a wide range of clinical manifestations and, in children, may present as roseola infantum, febrile seizures, aphthous stomatitis, mononucleosis-like syndrome, or fever of unknown origin. This article reports a rare case of congenital HHV-6 infection in a newborn. To date, both Russian and international publications provide very limited descriptions of such cases, which, in our opinion, reflects a significant knowledge gap among neonatologists regarding this condition. We discuss the clinical forms of HHV-6 infection in neonates, rare case presentations, and current approaches to diagnosis and treatment.
About the Authors
A. L. Karpova
Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation; Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Anna L. Karpova, MD, PhD.
Scopus Author ID: 57197280474.
2/44 Salyama Adilya Str., Moscow 123423;
2/1 bldg. 1, Barrikadnaya Str., Moscow 123993;
5 Revolutsionnaya Str., Yaroslavl 150000
A. V. Mostovoi
Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation; Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Aleksei V. Mostovoi, MD, PhD.
Scopus Author ID: 57201723894.
Wos ResearcherID: AAR-7908-2021.
2/44 Salyama Adilya Str., Moscow 123423;
2/1 bldg. 1, Barrikadnaya Str., Moscow 123993;
5 Revolutsionnaya Str., Yaroslavl 150000
A. A. Baranov
Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Andrei A. Baranov, MD, Dr Sci Med, Prof.
Scopus Author ID: 7201565006.
5 Revolutsionnaya Str., Yaroslavl 150000
L. A. Anikeeva
Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department
Russian Federation
Russian Federation
Lyubov A. Anikeeva, MD.
2/44 Salyama Adilya Str., Moscow 123423
E. V. Klubnichkina
Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department
Russian Federation
Russian Federation
Ekaterina V. Klubnichkina, MD.
2/44 Salyama Adilya Str., Moscow 123423
A. L. Zaplatnikov
Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Andrei L. Zaplatnikov, MD, Dr Sci Med, Prof.
2/1 bldg. 1, Barrikadnaya Str., Moscow 123993
L. N. Karpov
Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Leonid N. Karpov, MD.
135 Rublevskoe Shosse, Moscow 121552
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For citations:
Karpova A.L., Mostovoi A.V., Baranov A.A., Anikeeva L.A., Klubnichkina E.V., Zaplatnikov A.L., Karpov L.N. Congenital human herpesvirus 6 infection in a full-term newborn: literature review and case report. Obstetrics, Gynecology and Reproduction. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.635
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