Preview

Obstetrics, Gynecology and Reproduction

Advanced search

ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS SYSTEM IN PATIENTS AT RISK FOR OBSTETRIC PATHOLOGY. SYSTEMIC APPROACH TO DIAGNOSIS AND THERAPY

Full Text:

Abstract

This article describes the features of the hemostatic system and endothelial function in pregnant patients who are at risk for obstetric complications: chronic hypertension, type 1 diabetes, gestational diabetes mellitus, epilepsy, a pathology of leg veins, miscarriage. Based on this study developed an algorithm for diagnosis of endothelial dysfunction
and pathology of the hemostatic system in these patients. Given the major pathogenetic aspects, provides detailed pharmacotherapy revealed pathology. Developed a scale of «the assessment of the thrombophilia and methods of its correction during pregnancy and on the background of extragenital pathology®», which allows you to identify and find a
differentiated pharmacotherapy with certain dosage, duration of the course in the dynamics and control, regardless of the methods and standards of determining the parameters of hemostasis.

About the Authors

E. M. Jobava
GBOU VPO RNIMU named after N.I. Pirogov of Ministry of Healthcare of Russia, Moscow
Russian Federation


K. R. Nekrasova
GBOU VPO RNIMU named after N.I. Pirogov of Ministry of Healthcare of Russia, Moscow
Russian Federation


D. P. Artisanova
GBOU VPO RNIMU named after N.I. Pirogov of Ministry of Healthcare of Russia, Moscow
Russian Federation


L. A. Heidar
GBOU VPO RNIMU named after N.I. Pirogov of Ministry of Healthcare of Russia, Moscow
Russian Federation


G. Yu. Sudakova
GBUZ Maternity home №5 of Moscow Department of Healthcare
Russian Federation


S. G. Danelyan
GBUZ Maternity home №18 of Moscow Department of Healthcare
Russian Federation


D. V. Blinov
GBOU VPO RNIMU named after N.I. Pirogov of Ministry of Healthcare of Russia, Moscow
Russian Federation


Yu. E. Dobrokhotova
GBOU VPO RNIMU named after N.I. Pirogov of Ministry of Healthcare of Russia, Moscow
Russian Federation


References

1. Абрамченко В.В. Рациональная фармакотерапия патологии беременности и родов /В.В. Абрамченко, И.Н. Бойко. Спб. 2004;304 с.

2. Сухих Г.Т., Вихляева Е.М., Ванько Л.В. и др. Эндотелиальная дисфункция в генезе перинатальной патологии. Акушерство и гинекология. 2008; 5: 3-7.

3. Omar Farouque H.M., Meredith I.T. Relative contribution of vasodilator prostanoids, NO,and KATP channels to human forearm metabolic vasodilation. Am. J. Physiol. Heart Circ. Physiol. 2003; 284: 2405-2411.

4. Szecsi P.B., Jorgensen M., Klajnbard A., Andersen M.R., Colov N.P., Stender S.Haemostatic reference intervals in pregnancy. Thromb Haemost. 2010 Apr.; 103 (4): 718-27. Epub. 2010. Feb. 19.


For citation:


Jobava E.M., Nekrasova K.R., Artisanova D.P., Heidar L.A., Sudakova G.Yu., Danelyan S.G., Blinov D.V., Dobrokhotova Yu.E. ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS SYSTEM IN PATIENTS AT RISK FOR OBSTETRIC PATHOLOGY. SYSTEMIC APPROACH TO DIAGNOSIS AND THERAPY. Obstetrics, Gynecology and Reproduction. 2013;7(1):45-53. (In Russ.)

Views: 189


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)