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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS SYSTEM IN PATIENTS AT RISK FOR OBSTETRIC PATHOLOGY. SYSTEMIC APPROACH TO DIAGNOSIS AND THERAPY</article-title><trans-title-group xml:lang="ru"><trans-title>ДИСФУНКЦИЯ ЭНДОТЕЛИЯ И СИСТЕМА ГЕМОСТАЗА В ГРУППАХ РИСКА ПО РАЗВИТИЮ АКУШЕРСКОЙ ПАТОЛОГИИ. СИСТЕМНЫЙ ПОДХОД К ДИАГНОСТИКЕ И ТЕРАПИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джобава</surname><given-names>Э. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Jobava</surname><given-names>E. M.</given-names></name></name-alternatives><email xlink:type="simple">lis9@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Некрасова</surname><given-names>К. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Nekrasova</surname><given-names>K. R.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артизанова</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Artisanova</surname><given-names>D. P.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хейдар</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Heidar</surname><given-names>L. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Судакова</surname><given-names>Г. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sudakova</surname><given-names>G. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данелян</surname><given-names>С. Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Danelyan</surname><given-names>S. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinov</surname><given-names>D. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доброхотова</surname><given-names>Ю. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrokhotova</surname><given-names>Yu. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GBOU VPO RNIMU named after N.I. Pirogov of Ministry of Healthcare of Russia, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ Родильный дом №5 ДЗ г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GBUZ Maternity home №5 of Moscow Department of Healthcare</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ Родильный дом №18 ДЗ г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GBUZ Maternity home №18 of Moscow Department of Healthcare</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>31</day><month>05</month><year>2016</year></pub-date><volume>7</volume><issue>1</issue><fpage>45</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Jobava E.M., Nekrasova K.R., Artisanova D.P., Heidar L.A., Sudakova G.Y., Danelyan S.G., Blinov D.V., Dobrokhotova Y.E., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Джобава Э.М., Некрасова К.Р., Артизанова Д.П., Хейдар Л.А., Судакова Г.Ю., Данелян С.Ж., Блинов Д.В., Доброхотова Ю.Э.</copyright-holder><copyright-holder xml:lang="en">Jobava E.M., Nekrasova K.R., Artisanova D.P., Heidar L.A., Sudakova G.Y., Danelyan S.G., Blinov D.V., Dobrokhotova Y.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/11">https://www.gynecology.su/jour/article/view/11</self-uri><abstract><p>This article describes the features of the hemostatic system and endothelial function in pregnant patients who are at risk for obstetric complications: chronic hypertension, type 1 diabetes, gestational diabetes mellitus, epilepsy, a pathology of leg veins, miscarriage. Based on this study developed an algorithm for diagnosis of endothelial dysfunctionand pathology of the hemostatic system in these patients. Given the major pathogenetic aspects, provides detailed pharmacotherapy revealed pathology. Developed a scale of «the assessment of the thrombophilia and methods of its correction during pregnancy and on the background of extragenital pathology®», which allows you to identify and find adifferentiated pharmacotherapy with certain dosage, duration of the course in the dynamics and control, regardless of the methods and standards of determining the parameters of hemostasis.</p></abstract><trans-abstract xml:lang="ru"><p>В данной статье описаны особенности системы гемостаза и функции эндотелия у беременных пациенток, относящихся к группе риска по развитию акушерских осложнений: хроническая артериальная гипертензия, сахарный диабет 1-го типа, гестационный сахарный диабет, эпилепсия, патология вен нижних конечностей, невынашивание беременности. На основании проведенного исследования разработан алгоритм диагностики дисфункции эндотелия и патологии системы гемостаза у данных пациенток. С учетом основных патогенетических аспектов приведена подробная фармакотерапия выявленной патологии. Разработана шкала «Оценки степени тромбофилии и методов ее коррекции во время беременности и на фоне экстрагенитальной патологии®», которая позволяет определить и подобрать дифференцированную фармакотерапию с определенной дозировкой, длительностью курса и контролем в динамике, независимо от методов и норм определения параметров гемостаза.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>БЕРЕМЕННОСТЬ</kwd><kwd>ДИСФУНКЦИЯ ЭНДОТЕЛИЯ</kwd><kwd>ПАТОЛОГИЯ СИСТЕМЫ ГЕМОСТАЗА</kwd><kwd>ФАРМАКОТЕРАПИЯ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>endothelial dysfunction</kwd><kwd>hemostatic pathology</kwd><kwd>pharmacotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Абрамченко В.В. Рациональная фармакотерапия патологии беременности и родов /В.В. Абрамченко, И.Н. Бойко. Спб. 2004;304 с.</mixed-citation><mixed-citation xml:lang="en">Абрамченко В.В. 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