In present work urgency of the problem of HPV-associated cervical disease in reproductive age is justified. While monitoring 170 patients new approaches of improvement of cervical cancer secondary prevention methodswere proposed. These methods optimize non-invasive diagnostics of HPV-related precancerous cervicitis as its early indicators. Taking into account increase in incidence of cervical cancer in reproductive age, various tactics of patients with human papilloma virus infection (HPV) follow up based on complementary usage of traditional methods and new optical technologies - optical coherence tomography (OCT) in the diagnostic phase and photodynamic therapy (PDT) as a treatment method were considered. We justify the expediency of treatment withPolygynaxsuppository at different therapy stages of patients with chronic HPVand use of new modification of OCT (speed imaging 8-10 frames per second), which allows to determine the size of the tank and the main foci of infection that maximally eliminates random biopsy and allows to assess surface of eсtocervixafter treatment in dynamics. The authors suppose that the use of the proposed tactics in chronic cervicitis associated with HPV, will optimize the diagnostic process by eliminating unjustified cervical trauma, as well as to justify sparing therapeutic effect in women of reproductive age

Anatomic changes ofparaurethral tissue in women with relapse of urinary incontinence due to stress may testify deficiency or dysplasiaof connective tissue. These may serve as reason of low efficacy of methods with use of own tissues for prolapse correction and urinary incontinence management. These determine the necessity of synthetic materials use.

In current work examination of 150 obese women with normal body weight was conducted. Peculiarities of pregnancy period and delivery are described. The structure of developed complications, as well as prevalence of nonalcoholic fatty liver disease among them are presented. It is revealed, that in 52% of pregnant women with obesity ultrasound signs of fatty degeneration of the liver are present. However, typical changes in blood biochemical analysis are detected only in 12% of patients. Thus, management of pregnancy in obese women should includeliver ultrasound examination. And in case of evaluation of fatty liver distrophyhepatoprotectors and membrane stabilizers with low fatty diet should be indicated.

The article describes the present views on the etiology, pathogenesis and morphogenesis of uterine myoma. The data on the role of steroid hormones and their receptors, growth factors, and processes of proliferation and apoptosis, and also compares the types of growth of uterine myoma according to the histological types of tumor development. Pressing questions organ preservation treatment of uterine myoma in women of reproductive age.

Prospective examination of 21 pregnant women with chronic arterial hypertension, 81 pregnant women with preeclamsia of various degree of severity and 25 healthy pregnant women was conducted. Comparative assessment of neurospecific proteins NSE and GFAP in blood serum and also immunomorphologic investigation of placenta tissue in women with hypertension and preeclampsia was demonstrated. Compared to blood serum and placenta tissue taken from women with preeclamsia, in women with arterial hypertension neurospecific proteins with high immunogenic activity that may lead to development of severe immunopathologic process were not discovered. Pregnancy prolongation with adequate hypotensive therapy and good blood pressure control is possible. Development of preeclampsia is associated with sudden increase in neurospecific protein levels, severe immune endothelial damage of macro-and microcirculation vessels; To stop the progression of this process is possible only with delivery, that is indicated in case of eclampsia, severe preeclampsia and in its moderate forms ineffective treatment.