Preview

Obstetrics, Gynecology and Reproduction

Advanced search

CHRONIC CERVICITIS AND HPV-INFECTION IN REPRODUCTIVE PERIOD. ROUTS TO DECREASE DIAGNOSTIC AND TREATMENT AGRESSION

Full Text:

Abstract

In present work urgency of the problem of HPV-associated cervical disease in reproductive age is justified. While monitoring 170 patients new approaches of improvement of cervical cancer secondary prevention methodswere proposed. These methods optimize non-invasive diagnostics of HPV-related precancerous cervicitis as its early indicators. Taking into account increase in incidence of cervical cancer in reproductive age, various tactics of patients with human papilloma virus infection (HPV) follow up based on complementary usage of traditional methods and new optical technologies - optical coherence tomography (OCT) in the diagnostic phase and photodynamic therapy (PDT) as a treatment method were considered. We justify the expediency of treatment withPolygynaxsuppository at different therapy stages of patients with chronic HPVand use of new modification of OCT (speed imaging 8-10 frames per second), which allows to determine the size of the tank and the main foci of infection that maximally eliminates random biopsy and allows to assess surface of eсtocervixafter treatment in dynamics. The authors suppose that the use of the proposed tactics in chronic cervicitis associated with HPV, will optimize the diagnostic process by eliminating unjustified cervical trauma, as well as to justify sparing therapeutic effect in women of reproductive age

About the Authors

T. S. Kachalina
GBOU VPO NizhnyNovgorod State Medical Academy Ministry Of Health and Social Development of Russian Federation
Russian Federation


N. M. Shakhova
GBOU VPO NizhnyNovgorod State Medical Academy Ministry Of Health and Social Development of Russian Federation
Russian Federation


O. V. Kachalina
GBOU VPO NizhnyNovgorod State Medical Academy Ministry Of Health and Social Development of Russian Federation
Russian Federation


D. D. Eliseyeva
GBOU VPO NizhnyNovgorod State Medical Academy Ministry Of Health and Social Development of Russian Federation
Russian Federation


References

1. Апгар Б.С, Броцман Г.Л, Шпицер М. Клиническая кольпосопия. Иллюстрированное руководство. Пер. с англ под общей ред. В.Н. Прилепской. М. 2012.

2. Барышников А.Н., Новиков В.В. Программированная клеточная смерть (апоптоз). Клиническая онкогематология: руководство для врачей. М. 2007; 99-106.

3. Бауэр Г. Цветной атлас по кольпоскопии. М. 2007; 288 с.

4. Дамиров М.М. Радиоволновые, криогенные и лазерные технологии в диагностике и лечении в гинекологии.М. 2011.

5. Дисаи Ф.Дж, Крисман У.Т. Клиническая онкогинекология в 3 томах. Том 1. Переводчик Е. Новикова. 2011

6. Краснопольский В.И., Шипулина О.Ю., Мельник Т.Н., Михеева И.В., Серова О.Ф., Зароченцева Н.В., Белая Ю.М. Инфицированность вирусом папилломы человека среди девочек-подростков в Московской области. Российский вестник акушера-гинеколога. 2010; 5: 46-49.

7. Кузнецова И.А. Диагностические возможности оптической когерентной томографии в оценке состояния шейки матки. Дисс. канд. мед. наук. 2003; 157с.

8. Прилепская В.Н., Костава М.Н. Возможности терапии папилломавирусной инфекции. РМЖ. 2009; 17 (1): 16-19.

9. Роговская С.И. Практическая кольпоскопия. М.2011.

10. Роговская С.И. Папилломавирусная инфекция у женщин и патология шейки матки. 2-е изд., испр. и доп. М. 2011.

11. Роговская С.И., Акопова Е.С., Коган Е.А. Совершенствование лечебно-диагностических подходов к ВПЧ-инфекции гениталий. РМЖ. 2011; 20: 1238.

12. Роговская С.И. Папилломавирусная инфекция нижних отделов гениталий: клиника, диагностика, лечение. Дисс. докт. мед. наук. 2003.

13. Серов В.Н. Изучение эффективности Полижинакса в лечении неспецифических бактериальных и грибковых кольпитов. АГ-инфо. 2003. сентябрь.

14. Kanodia S., Fahey L.M., Kast W.M. Mechanisms used by human papillomavirus to escape the host immune response. Curr. Cancer. Drug. Targets. 2007; 7: 79-89.

15. Moscicki A.B., Ma Y. et al. The role of sexual behavior and HPV persistence in predicting repeated infections with new HPV types. Cancer. Epidemiol. Biomarkers. Prev. 2010 Aug.; 19 (8): 2055-2065.

16. Schiffman M., Castle P.E. The promise of global cervical-cancer prevention. N. Engl. J. Med. 2005; 353: 2101-2104.

17. Schiffman M.H., Kiviat N.B. et al. Accuracy and interlaboratory reability of human papillomavirus DNA testing By Hybrid Capture. J. Clin. Microbiol. 1995; 33: 545 p.

18. Wright T.C., Cox J.T. et al. American Society for Colposcopy and Cervical Pathology. 2001 consensus guidelines for the management of women with cervical intraepithelial neoplasia. Am. J. Obstet. Gynaecol. 2003 Jul; 189 (1): 295-304.


For citation:


Kachalina T.S., Shakhova N.M., Kachalina O.V., Eliseyeva D.D. CHRONIC CERVICITIS AND HPV-INFECTION IN REPRODUCTIVE PERIOD. ROUTS TO DECREASE DIAGNOSTIC AND TREATMENT AGRESSION. Obstetrics, Gynecology and Reproduction. 2012;6(4):6-12. (In Russ.)

Views: 196


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)