Perinatal hypoxic-ischemic damage of the CNS is a major cause of mortality and neonatal incapacitating. The severity and prognosis is not always possible to accurately determine by clinical and tools methods of examination. Neurospecific proteins (NSP) could be as markers of pathological processes. One of the most studied among the NSP are gliofibrillary acid protein - GFAP, a structural protein of intermediate filaments of astrocytes, and neuron-specific enolase - NSE, neuronal cytoplasmic glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to 2-phosphoenolpyruvate. Investigation of the NSP concentration in the serum could be useful to evaluate the resistance of the BBB, determining the severity of CNS damage and prognosis for a disease in children with perinatal hypoxic-ischemic damages of the CNS.

The purpose of this study was to examine changes in indicators that reflect the activation of the humoral immune system, the severity of the destructive processes and autoimmune reactions in patients with neoplastic diseases of the uterus. The testing revealed significantly higher concentrations of IgA, the levels of circulating immune complexes and antibodies to antigens of native DNA. The findings suggest the importance of the activation of immune (autoimmune) reactions and destructive processes in pathogenetic mechanisms of development of uterine fibroids and cancer of the uterus.

This article presents results of authors' own investigations using a new approach to treatment of adenomyosis (uterine endometriotic lesions which are most often found within the structure of genital endometriosis) and differential characteristics of different (by their activity) forms of disease. The investigation included 492 female patients. Depending on the intensity of main clinical manifestations characteristic for adenomyosis, the examined females were divided into 2 groups: the 1st group comprised 344 patients with clinically active adenomyosis, and the second group included 148 patients with clinically inactive adenomyosis. 321 (65.2%) out of 492 (100%) adenomyosis patients were subjected to separate therapeutic and diagnostic endocervical and uterine cavity curettage followed by hysterectomy. 171 (34.8%) of females have received a course of conservative treatment (in 114 patients of the total - after separate diagnostic curettage). 113 adenomyosis patients (64 from group I and 49 from group II - without hysterectomy) have received a 6-month course of treatment by GnRh-A (gonadotropin-releasing hormone agonists) with pronounced positive effect. After completion of the GnRh-A course, a complex treatment was used with monophasic combination oral contraceptives (OC) in the extended regimen. This approach is highly efficacious and to a large extent enables to put into effect the organ-saving tactics of adenomyosis treatment which is particularly important in the reproductive age.

The authors describe a case study of cervical pregnancy with organsparing surgical treatment in a 35 years woman.

The authors describe a case study of giant cervical myoma with organ-sparing surgical treatment in a 28 years woman.