Female pregravidar preparation mostly defines pregnancy course and perinatal outcome. This article addresses the algorithm of patient examination during the infertile couple female pregravidar preparation and stages of pregravidar preparation, such as periconception prophylaxis, 3-month preparation for conception including of periconception polyvitamin and folic acid administration, and management of early pregnancy taking into account the revealed risk factors of complicated course of occurred pregnancy.

Pathogenesis of isolated urogenital disorders in post-menopausal females is often rooted in reduced production of female sex hormones. As a rule, such disorders are not related to infectious diseases. Therefore, the main objective of therapy of postmenopausal urogenital disorders is to supplement the deficiency of female sex hormones. Topical administration of therapeutic doses of estriol as a cream or Ovestin suppositoria, is recognized as one of the safest methods of treatment. Upon completion of the treatment course, which duration is 3 weeks, a switching to maintenance therapy is indicated.

This article reviews the objectives of combination biochemical screening of unfavorable outcomes of pregnancy in trimester I. The characterization of prenatal screening markers is given, for example, β-hCG (beta-human chorionic gonadotropin) and РАРР-А (pregnancy-associated plasma protein A). The international and national approaches to the algorithm of carrying out of prenatal screening and conceptualization about prediction of pregnancy complications based on results of biochemical screening of serum concentrations of β-hCG and PAPP-A, are reviewed

A prospective, cohort study of the pregnancy and labor course in obese patients was carried out during the 2009 - 2011 period. Depending on the extent of obesity, all pregnant females were divided into three subgroups. The first subgroup comprised patients with grade I obesity (BMI - 30-34.9, n = 60), second group included patients with grade 2 obesity (BMI - 35-39.9, n = 28), and the third group included patients with grade 3 obesity (BMI - 40 and over, n = 12). All patients received complex clinical and laboratory examination. It was found that regardless of obesity grade, in the 3rd trimester every other patient develops gestosis, and every third patient develops threat of preterm labor. Females with grade 3 obesity are at a higher risk of development of not only complications of pregnancy, but also of unfavorable perinatal outcomes at that. These results and results of laboratory examinations confirm that obesity is the unfavorable background for pregnancy progression.

One of the commonest forms of genital endometriosis is the ovarian endometriotic lesion. The main treatment step, surgical intervention, may promote endometriosis progression if performed non-radically. Analysis of clinical particulars of disease in two comparison groups. The clinical particulars of disease were studied on 139 patients divided into 2 groups: the first group (41 females) comprised patients with repeated hospitalization due to recurrent endometriotic cysts at the backdrop of conducted anti-relapsing therapy. The second group included 98 patients hospitalized with newly diagnosed endometriotic cyst, and in whom after surgical treatment, there was no recurrence during 2-3 years after surgery. For evaluation of recurrence risk, 10 criteria have been assessed: the immunohistochemical parameters, such as CD-95; Ki-67; CD-34; ММР-7; TIMP-1; EGF; the level of circulation using color Doppler mapping; diagnosed peritoneal endometriosis; presence of microfocal ovarian endometriosis and intensity of clinical manifestations. Should 3 or less signs be present, this was defined as the low rate of risk of recurrence, and in case of 4, 5 or 6 signs present, this was defined as the moderate rate of risk of recurrence. In case of high recurrence rate, the post-operation therapy was conducted using hormonal drugs (GnRh-A for 6 months). In case of moderate rate of risk the administration of a variant of hormonal therapy was decided upon individually. In case of low recurrence rate, the combination oral contraceptives were administered aimed at prophylaxis of recurrence. The results of investigation confirm that studying of individual prognosis of recurrence in patients with ovarian endometriotic cysts is gaining an increasingly greater significance owing to the necessity to draw up a rational plan of differential approach to treatment based on scientifically substantiated prognosis

This article presents modern insights into the pathogenesis of endometrium hyperplastic processes, matrix metalloproteinases and their tissue inhibitors, and their role in development of endometrium hyperplasia. A pathogenetic substantiation is given for use of Lucrin Depot, which affects the key molecular mechanisms of development of hyperplastic processes, with the objective of pharmacological correction of this pathology