Connective tissue dysplasia in the genesis of cervical incompetence
Abstract
Aim: to study a role of undifferentiated connective tissue dysplasia (uCTD) in etiology of cervical incompetence and its effect on pregnancy and childbirth course.
Material and Methods. There were enrolled 60 patients with cervical incompetence. Patients were divided into 3 groups according to the modified CTD scale: group 1 - patients without uCTD (n = 21); group 2 - patients with mild uCTD (n = 25); group 3 - patients with moderate-to-severe uCTD (n = 14). Intensity of CTD clinical signs was assessed based on health status, gynecological and obstetric history, the course of pregnancy, labor and the postpartum period.
Results. It was found that patients with more prominent CTD developed earlier (r-Spearman = -0.26) and more marked (r-Spearman = -0.29) cervical shortening and opening of the internal orifice of the uterus (r-Spearman = 0.28). It was also noted that likelihood of occurring preterm labor was significantly higher in patients with CTD (p = 0.02).
Conclusion. The data obtained evidence that uCTD affects intensity of manifested cervical insufficiency and rate of preterm delivery.
About the Authors
E. V. Fotina
Lomonosov Moscow State University
Russian Federation
Russian Federation
Evgenia V. Fotina - MD, Researcher, Medical Research Educational Center, Lomonosov Moscow State University.
27 Lomonosovskiy Ave., Moscow 119192.
R. R. Zakirova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Renata R. Zakirova - 6th year Student, Faculty of Fundamental Medicine, Lomonosov Moscow State University.
27 Lomonosovskiy Ave., Moscow 119192.
M. V. Alekseenkova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Maria V. Alekseenkova - MD, PhD, Assistant, Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine, Lomonosov Moscow State University.
27 Lomonosovskiy Ave., Moscow 119192.
O. B. Panina
Lomonosov Moscow State University
Russian Federation
Russian Federation
Olga B. Panina - MD, Dr Sci Med, Professor, Head of the Department of Obstetrics, Gynecology and Reproductive Medicine, Medical Research Educational Center, Head of the Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine, Lomonosov Moscow State University.
27 Lomonosovskiy Ave., Moscow 119192.
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Supporting agencies: The study was conducted within the framework of the State Assignment by using the equipment purchased in accordance with the Lomonosov Moscow State University scientific development program.
For citation:
Fotina E.V., Zakirova R.R., Alekseenkova M.V., Panina O.B. Connective tissue dysplasia in the genesis of cervical incompetence. Obstetrics, Gynecology and Reproduction. 2021;15(1):41-50. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.131
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