Preview

Obstetrics, Gynecology and Reproduction

Advanced search

Signs of connective tissue dysplasia in women with genital prolapse

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.124

Full Text:

Abstract

Introduction. Despite a long history of the disease, genital prolapse still have not been definitively solved. A relevance of pelvic organ prolapse in women has been increasing in recent years largely due to a change in the quality of life and desire to sustain their youth. The number of studies pinpointing the cause of the disease in connective tissue dysplasia (CTD) has been increasing annually.
Aim: to conduct a systematic analysis and determine most common signs of CTD in women with genital prolapse.
Materials and methods. CTD criteria and the relationship with genital prolapse were analyzed. The study was conducted using questionnaires and including clinical studies examining residents of the Belgorod region (135 women). The main group included 91 patients who had signs of pelvic organ prolapse, and control group consisted of 44 healthy women. CTD intensity score proposed by T.Yu. Smolnova et al. (2003) was used to assess signs of dysplasia in women examined allowing to build up three groups in which each symptom was evaluated as severity score.
Results. Asthenic constitution was noted in high percentage of women suffering from genital prolapse (16.70 ± 0.38 %) compared with healthy women (2.30 ± 0.15 %; p = 0.016). Mild bruising, increased tissue bleeding tended to rise in main vs. control group (16.50 ± 0.37 % in main group and 0.0 in control group; p = 0.016). Signs of varicose veins and hemorrhoids requiring no surgical treatment were found in 33.00 ± 0.47 % and 4.50 ± 0.21 % in main vs. control group (p = 0.0002), respectively. Genital prolapse and hernia in first-line relatives were recorded in 9.90 ± 0.30 % in main group (p = 0.031), women without signs of prolapse did not indicate prolapse in close relatives.
Conclusion. Asthenic constitution, hernias, varicose veins and hemorrhoids, female pelvic and hernial prolapse in close female relatives, a tendency to mild bruising, skeletal anomalies, elastosis skin were among common CTD signs in women with genital prolapse.

About the Authors

A. S. Ustyuzhina
Belgorod State National Research University; Belgorod Regional Clinical Hospital of St. Joasaph
Russian Federation

Alexandra S. Ustyuzhina - MD, Postgraduate Student, Department of Obstetrics and Gynecology, Belgorod State National Research University; Obstetrician-Gynecologist, Belgorod Regional Clinical Hospital of St. Joasaph.
85 Pobedy Str., Belgorod 308007; 8/9 Nekrasov Str., Belgorod 308007.



M. A. Solodilova
Kursk State Medical University, Health Ministry of Russian Federation
Russian Federation

Maria A. Solodilova - MD, Dr Sci Biol, Professor, Department of Biology, Medical Genetics and Ecology, Kursk State Medical University.
3 Karl Marks Str., Kursk 305041.



A. V. Polonikov
Kursk State Medical University, Health Ministry of Russian Federation
Russian Federation

Alexei V. Polonikov - MD, Dr Sci Med, Professor, Department of Biology, Medical Genetics and Ecology, Kursk State Medical University.
3 Karl Marks Str., Kursk 305041.



S. P. Pakhomov
Belgorod State National Research University
Russian Federation

Sergey P. Pakhomov - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Belgorod State National Research University, Belgorod National Research University.
85 Pobedy Str., Belgorod 308007.



U. G. Shokirova
Belgorod State National Research University
Russian Federation

Umeda G. Shokirova - MD, Postgraduate Student, Department of Obstetrics and Gynecology, Belgorod State National Research University.
85 Pobedy Str., Belgorod 308007.



References

1. Bezmenko A.A., Berlev I.V. Etiology and pathogenesis of genital prolapse. [Etiologiya i patogenez genital'nogo prolapsa]. Zhurnal akusherstva i zhenskih boleznej. 2011;60(1):129-38. (In Russ.).

2. Marukhno Yu.I., Pyatnakovsky A.S. Connective tissue dysplasia in athletes. [Displaziya soedinitel'noj tkani u sportsmenov]. Medichnii perspektivi. 2012;17(1):114-8. (In Russ.).

3. Buchsbaum G.M., Duecy E.E., Kerr L.A. et al. Urinary incontinence in nulliparous women and their parous sisters. Obstet Gynecol. 2005;106(6):1253-8. https://doi.org/10.1097/01.AOG.0000187309.46650.b2.

4. Dubinskaya E.D., Babicheva I.A., Kolesnikova S.N. et al. Clinical specificities and risk factors of early forms of pelvic organ prolapse. [Klinicheskie osobennosti i faktory riska rannih form prolapsa tazovyh organov]. Voprosy ginekologii, akusherstva i perinatologii. 2015;14(6):5 11. (In Russ.).

5. Kluivers K.B., Dijkstra J.R., Hendriks J.C. et al. COL3A1 2209G >A is a predictor of pelvic organ prolapsed. Int Urogynecol J Pelvic Floor Dysfunct. 2009;20:1113-8. https://doi.org/10.1007/s00192-009-0913-y.

6. Smolnova T.Yu., Buyanova S.N., Savelyev S.V., Petrova V.D. Connective tissue dysplasia as one of the expected causes of urinary incontinence in females with genital prolapse. [Displaziya soedinitel'noj tkani kak odna iz vozmozhnyh prichin nederzhaniya mochi u zhenshchin s prolapsom genitalij[. Urologiya. 2001;(2):25-30. (In Russ.).

7. Falconer C., Ekman G., Malmstrom A., Ulmsten U. Decreased collagen synthesis in stress-incontinent women. Obstet Gynaecol. 1994;84(4):583-6.

8. Cervigni M., Natale F. The use of synthetics in the treatment of pelvic organ prolapse. Curr Opin Urol. 2001;11(4):429-35. https://doi.org/10.1097/00042307-200107000-00016.

9. Kadurina T.I. Hereditary collagenopathies: clinic, diagnosis, treatment and medical examination. [Nasledstvennye kollagenopatii: klinika, diagnostika, lechenie i dispanserizaciya]. SPb.: Nevskij dialekt, 2000. 270 s. (In Russ.).

10. Radzinsky V.E., Shalaev O.N., Durandin Yu.M. et al. Perineology. Descensus and prolapse of genitals: study guide. [Perineologiya. Opushchenie i vypadenie polovyh organov: uchebnoe posobie]. Moskva: RUDN, 2008. 256 s. (In Russ.).

11. Smolnova T.Yu., Buyanova S.N., Savelyev S.V. et al. The phenotypical symptom complex of connective tissue dysplasia in females. [Fenotipicheskij simptomokompleks displazii soedinitel'noj tkani u zhenshchin]. Klinicheskaya medicina. 2003;81(8):42-7. (In Russ.).

12. Altman D., Forsman M., Falconer C., Lichtenstein P. Genetic influence on stress urinary incontinence and pelvic organ prolapse. Eur Urol. 2008;54(4):918-22. https://doi.org/10.1016/j.eururo.2007.12.004.

13. Mothes A.R., Radosa M.P., Altendorf-Hofmann A., Runnebaum I.B. Risk index for pelvic organ prolapse based on established individual risk factors. Arch Gynecol Obstet. 2016;293(3):617-24. https://doi.org/10.1007/s00404-015-3863-2.

14. Salter S.A., Batra R.S., Rohrer T.E. et al. Striae and pelvic relaxation: two disorders of connective tissue with a strong association. J Invest Dermatol. 2006;126(8):1745-8. https://doi.org/10.1038/sj.jid.5700258.

15. Lammers K., Lince S.L., Spath M.A. et al. Pelvic organ prolapse and collagen-associated disorders. Int Urogynecol J. 2012;23(3):313-9. https://doi.org/10.1007/s00192-011-1532-y.


For citation:


Ustyuzhina A.S., Solodilova M.A., Polonikov A.V., Pakhomov S.P., Shokirova U.G. Signs of connective tissue dysplasia in women with genital prolapse. Obstetrics, Gynecology and Reproduction. 2021;15(1):32-40. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.124

Views: 219


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)