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First trimester prenatal screening in multiple pregnancies. Part I: comparative analysis of serum proteins PAPP-A and p-hCG in pregnancies conceived spontaneously or by in vitro fertilization

https://doi.org/10.17749/2313-7347.2020.14.1.25-33

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Abstract

Introduction. Serum proteins PAPP-A (pregnancy-associated plasma protein-A) and β-hCG (the в-subunit of human chorionic gonadotropin) levels are components of the 1st trimester combined screening aimed to detect fetal aneuploidies. In contrast to singleton pregnancies, where the values are well established, this is not the case in twins.

Aim: a comparative analysis of serum proteins PAPP-A and β-hCG levels, as well as parameters PAPP-A MoM and β-hCG MoM in the first trimester during pregnancy with dichorionic diamniotic twins that occurred spontaneously or as a result of in vitro fertilization (IVF).

Materials and methods. The study group included multiple pregnancies as a result of IVF procedure (n = 100) and spontaneous multiple pregnancies (n = 121) considered as controls. The levels of PAPP-A, β-hCG, PAPP-A MoM and β-hCG MoM were compared using nonparametric Mann-Whitney U test.

Results. The PAPP-A MoM level resulted higher in the group of IVF twins (p = 0,007) compared to spontaneous twins: 1.28 [0.97; 1.89] vs. 1.12 [0.87; 1.40] (median [interquartile range]). There were no statistically significant differences in в-hCG levels between the groups of IVF twins and spontaneous twins.

Conclusion. The results justify the need for further study of PAPP-A and β-hCG to establish their association with adverse outcomes in both groups of multiple pregnancies.

About the Authors

V. I. Tsibizova
Almazov National Medical Research Centre, Health Ministry of Russian Federation
Russian Federation

Valentina I. Tsibizova - MD, Departments of Functional and Ultrasound Diagnostics.

2 Akkuratova St., Saint Petersburg 197341


I. E. Govorov
Almazov National Medical Research Centre, Health Ministry of Russian Federation
Russian Federation

Igor E. Govorov - MD, PhD, Obstetrician-Gynecologist, Research Laboratory of Operative Gynecology, Institute of Perinatology and Pediatrics, Scopus Author ID: 57188586021, Researcher ID: P-1257-2015.

2 Akkuratova St., Saint Petersburg 197341



T. М. Pervunina
Almazov National Medical Research Centre, Health Ministry of Russian Federation
Russian Federation

Tatiana М. Pervunina - MD, PhD, Director of the Institute of Perinatology and Pediatrics.

2 Akkuratova St., Saint Petersburg 197341



E. V. Komlichenko
Almazov National Medical Research Centre, Health Ministry of Russian Federation
Russian Federation

Eduard V. Komlichenko - MD, Dr Sci Med, Deputy Director of the Institute of Perinatology and Pediatrics, Researcher ID: N-5315-2015.

2 Akkuratova St., Saint Petersburg 197341



E. K. Kudryashova
Leningrad Regional Clinical Hospital
Russian Federation

Elena K. Kudryashova - Head of the Department of Medical Genetic Counseling, Leningrad Regional CH.

45-49 Lunacharsky Ave., Saint Petersburg 194291



D. V. Blinov
Institute for Preventive and Social Medicine; Lapino Clinical Hospital, GC «Mother and Child»
Russian Federation

Dmitry V. Blinov - MD, PhD, MBA, Head of Medical and Scientific Affairs, IPand SM; Neurologist, Lapino Clinic Hospital, GC Mother and Child, Researcher ID: E-8906-2017. RSCI: 9779-8290.

4-10 Sadovaya-Triumfalnaya St., Moscow 127006; 111,1-e Uspenskoe shosse, Lapino, Moscow region 143081



A. D. Makatsariya
Sechenov University
Russian Federation

Alexander D. Makatsariya - MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics and Gynecology, Scopus Author ID: 6602363216, Researcher ID: M-5660-2016.

62 St. Zemlyanoi Val, Moscow 109004



G. C. Di Renzo
Sechenov University; Center for Prenatal and Reproductive Medicine, University of Perugia
Italy

Gian Carlo Di Renzo - MD, Professor, Department of Obstetrics and Gynecology, SU; Director of the Center for Prenatal and Reproductive Medicine, University of Perugia,; Honorary Secretary General of the International Federation of Gynecology and Obstetrics (FIGO), Scopus Author ID: 7103191096, Researcher ID: P-3819-2017.

62 St. Zemlyanoi Val, Moscow 109004; Umbria, Perugia, Piazza Italia



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For citation:


Tsibizova V.I., Govorov I.E., Pervunina T.М., Komlichenko E.V., Kudryashova E.K., Blinov D.V., Makatsariya A.D., Di Renzo G.C. First trimester prenatal screening in multiple pregnancies. Part I: comparative analysis of serum proteins PAPP-A and p-hCG in pregnancies conceived spontaneously or by in vitro fertilization. Obstetrics, Gynecology and Reproduction. 2020;14(1):25-33. (In Russ.) https://doi.org/10.17749/2313-7347.2020.14.1.25-33

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)