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Preterm birth: from understanding of pathogenesis to pregnancy management

https://doi.org/10.17749/2313-7347.2018.12.4.047-051

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Abstract

Preterm birth is an important issue in the current obstetrics as it is associated with perinatal morbidity and mortality. Today, most studies are aimed at understanding of the pathogenesis of preterm delivery. The known data on cytokine gene polymorphism indicate that in women with preterm birth, the presence of pro-inflammatory dominant alleles is typical. This may lead to increased production of pro-inflammatory cytokines in the utero-placental complex and may also initiate preterm delivery. At present, studies are under way to identify genes that determine the duration of the gestation period. A better understanding of the preterm birth pathogenesis is expected to help prevent this unfortunate outcome and decrease perinatal morbidity and mortality.

About the Authors

V. S. Belousova
I.M. Sechenov First Moscow State Medical University
Russian Federation

PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatology, Faculty of General and Preventive Medicine

8/2 Trubetskaya St., Moscow 119991, Russia

+7(499)7823045



A. N. Strizhakov
I.M. Sechenov First Moscow State Medical University
Russian Federation

MD, PhD, Professor, Academician of RAS, Head of Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine

8/2 Trubetskaya St., Moscow 119991, Russia



E. V. Timokhina
I.M. Sechenov First Moscow State Medical University
Russian Federation

MD, PhD, Professor, Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine

8/2 Trubetskaya St., Moscow 119991, Russia



O. A. Svitich
Scientific Research Institute of Vaccines and Serums named after I.I. Mechnikov
Russian Federation

MD, PhD, Professor, Head of Laboratory of Molecular Immunology

5А Malyi Kazennyi byst., Moscow 105064, Russia



I. M. Bogomazova
I.M. Sechenov First Moscow State Medical University
Russian Federation

PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatology, Faculty of General and Preventive Medicine,

8/2 Trubetskaya St., Moscow 119991, Russia



E. G. Pitskhelauri
I.M. Sechenov First Moscow State Medical University
Russian Federation

PhD, Associate Professor, Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine

8/2 Trubetskaya St., Moscow 119991, Russia



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For citation:


Belousova V.S., Strizhakov A.N., Timokhina E.V., Svitich O.A., Bogomazova I.M., Pitskhelauri E.G. Preterm birth: from understanding of pathogenesis to pregnancy management. Obstetrics, Gynecology and Reproduction. 2018;12(4):47-51. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.4.047-051

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)