A new approach to the diagnosis of endothelial dysfunction in pregnant women
https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.718
Abstract
Aim: improving diagnosis of vascular disorders during pregnancy by using morphometric examination of desquamated endothelial cells (DECs).
Materials and Methods. An observational prospective study assessing endothelial status in pregnant women and fetuses was carried out using the "case-control" method. 180 women in first trimester who had terminated pregnancy were examined: 90 patients were diagnosed with undeveloped pregnancy and instrumental removal of the fetal egg was performed, 90 women had a medical abortion on request. Endothelial dysfunction was diagnosed in all pregnant women, and morphometry of circulating DECs was performed. The data obtained further underwent statistical analysis.
Results. A comparative analysis of endothelial lesion markers in pregnant women demonstrated the diagnostic significance of DECs morphometric examination.
Conclusion. Morphometric examination of peripheral blood DECs may be a diagnostic marker of vascular disorders in pregnant women and represents a promising area to prevent obstetric and perinatal pathology.
About the Authors
M. M. Umakhanova
Russian University of Medicine, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Madina M. Umakhanova, MD, Dr Sci Med, Prof.
4 Dolgorukovskaya Str., Moscow 127006
A. V. Mironov
Russian University of Medicine, Ministry of Health of the Russian Federation; Demikhov City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
Aleksey V. Mironov, MD, Dr Sci Med.
4 Dolgorukovskaya Str., Moscow 127006
1/1 Velozavodskaya Str., Moscow 115280
M. R. Gabaraeva
Russian University of Medicine, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Milena R. Gabaraeva, MD, PhD.
4 Dolgorukovskaya Str., Moscow 127006
S. E. Arakelov
Demikhov City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
Sergey E. Arakelov, MD, Dr Sci Med, Prof.
1/1 Velozavodskaya Str., Moscow 115280
A. V. Zhukotsky
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Aleksandr V. Zhukotsky, MD, Dr Sci Med, Prof.
28 Orekhovy Boulevard, Moscow 115682
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Review
For citations:
Umakhanova M.M., Mironov A.V., Gabaraeva M.R., Arakelov S.E., Zhukotsky A.V. A new approach to the diagnosis of endothelial dysfunction in pregnant women. Obstetrics, Gynecology and Reproduction. 2026;20(3):420–429. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.718
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