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ENDOMETRIAL PRECANCER: DEFINITION OF CONCEPTS, TACTICS

https://doi.org/10.17749/2313-7347.2016.10.2.032-036

Abstract

Objective. To substantiate indications for a differential approach in the treatment of patients with atypical endometrial hyperplasia.

Materials and Methods.The results of surgical treatment in 132 patients with atypical endometrial hyperplasia have been studied.

Results. Post-operative diagnosis was:endometrial cancer – in 19%, atypical hyperplasia – in 35%, simple and complex hyperplasia – in 33%, only atrophic endometrial changes – in 13% of patients. The tumor was within the endometrium in 5 patients, the superficial invasion of the myometrium (1-2 mm) were in 8 patients, invasion to half of the myometrium – in 9 patients, invasion of more than half of the myometrium – in 3 patients.

Conclusion. The guestions of tactics of treatment of atypical endometrial hyperplasia is under discussion.

About the Authors

Iu. Iu. Tabakman
Clinical Oncology Dispensary number 1 Department of Health in Moscow
Russian Federation

MD, professor of the Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine First Moscow Medical Sechenov University,

Honoured Doctor of the Russian Federation, radiologist of the highest qualification category, manager radioisotope laboratory diagnostics, 

ul. Baumanskaya, 17/1, Moscow, 105005



A. G. Solopova
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation

MD, Professor of Department of Obstetrics and Gynecology,

Trubetskaya str., 8, p. 1, Moscow, 119991



A. Kh. Bishtavi
Moscow state University of Medical and Dentistry named after Evdokimov of the Ministry of Health Russian Federation
Russian Federation

PhD, Assistent Professor, Department of Obstetrics and Gynecology, 

ul. Delegatskaia, 20/1, Moscow, 127473



L. E. Idrisova
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation

PhD, researcher at the Department of the Ob/Gyn Department,

ul. Zemlyanoi Val, 62-1, Moscow, 109004



References

1. Perel'muter V.M. Sibirskii onkologicheskii zhurnal. 2008; 5 (29): 5-10.

2. Allison K.H., Reed S.D., Voigt L.F., Jordan C.D., Newton K.M., Garcia R.L. Diagnosing endometrial hyperplasia: why is it so difficult to agree? Am O Surg Pathol. 2008 May; 32 (5): 691-8.

3. Horn L.C., Schnurrbusch U., Bilek K., Hentschel B., Einenkel J. Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment. Int J Gynecol Cancer. 2004 Mar-Apr; 14 (2): 348-53.

4. Kimura T., Kamiura S., Komoto T., Seino H., Tenma K., Ohta Y., Yamamoto T., Saji F. Clinical over- and under-estimation in patients who underwent hysterectomy for atypical endometrial hyperplasia diagnosed by endometrial biopsy: the predictive value of clinical parameters and diagnostic imaging. Eur J Obstet Gynecol Reprod Biol. 2003 Jun 10; 108 (2): 213-6.

5. Kurman R.J., Kaminski P.F., Norris H.J. The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients. Cancer. 1985 Jul 15; 56 (2): 403-12.

6. Lacey J.V., Sherman M.E., Rush B.B. Absolute Risk of Endometrial Carcinoma During 20-Year Follow-Up Among Women With Endometrial Hyperplasia. J Clin Oncol. 2010 February 10; 28 (5): 788-792.

7. Masur M.T. Endometrial hyperplasia / adenocarcinoma, a conventional ahhroch. Ann Diagn Pathol. 2005 Jun; 9 (3): 174-81.

8. Mittal K., Da Costa D. Endometrial hyperplasia and carcinoma in endometrial polyps: clinicopathologic and follow-up findigs. Int J Gynecol Pathol. 2008 Jan; 27 (1): 45-8.

9. Rakha E., Wong S.C., Soomro I., Chaudry Z., Sharma A., Deen S., Chan S., Abu J., Nunns D., Williamson K., McGregor A., Hammond R., Brown L. Clinical outcome of atypical endometrial hyperplasia diagnosed on an endometrial biopsy: institutional experience and review of literature. Am J Surg Pathol. 2012 Nov; 36 (11): 1683-90.

10. Silverberg S.C. Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. Mod Pathol. 2000 Mar; 13 (3): 309-27.

11. Suh-Burgmann E., Hung Yu., Armstrong M. Complex Atypical Endometrial Hyperplasia. The Risk of Unrecognized Adenokarcinoma and Value of Preoperative Dilatation and Curettage. J Obstet Gynaecol. 2 009; 114: 523-9.

12. Terakawa N., Kigawa J., Taketani Y., Yoshikawa H., Yajima A., Noda K., Okada H., Kato J., Yakushiji M., Tanizawa O., Fujimoto S., Nozawa S., Takahashi T., Hasumi K.,

13. Furuhashi N., Aono T., Sakamoto A., Furusato M. The behavior of endometrial hyperplasia: a prospective study. Endometrial Hyperplasia Study Group. J Obstet Gynecol Res. 1997 Jun; 23 (3): 223-30.


Review

For citations:


Tabakman I.I., Solopova A.G., Bishtavi A.Kh., Idrisova L.E. ENDOMETRIAL PRECANCER: DEFINITION OF CONCEPTS, TACTICS. Obstetrics, Gynecology and Reproduction. 2016;10(2):32-36. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.2.032-036

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)