Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis
E. V. Virivskaya,
I. V. Ignatko,
I. A. Snimshchikova,
K. R. Bakhtiyarov,
A. S. Zueva,
T. D. Kapyrina https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.640
Abstract
Endometriosis is a chronic estrogen-dependent disease characterized by the ectopic growth of endometrium-like tissue outside the uterus. In recent years, increasing attention has been paid to the role of the Wnt/β-catenin signaling pathway in endometriosis pathogenesis, wherein it regulates cell proliferation, migration, invasion, and fibrosis. Hyperactivation of the Wnt/β-catenin cascade promotes disease progression, chronic inflammation, and adhesion formation. MicroRNAs modulating this signaling pathway are of particular interest, offering potential for endometriosis diagnostics and targeted therapy. Further research may lead to new treatment approaches and improved quality of patients’ life.
About the Authors
E. V. Virivskaya
Turgenev Orеl State University; Klinika Semeynaya LLC
Russian Federation
Russian Federation
Elena V. Virivskaya, MD, PhD.
95 Komsomolskaya Str., Orеl 302026
8 bldg. 6, Sadovaya-Karetnaya Str., Moscow 127006
I. V. Ignatko
Sechenov University
Russian Federation
Russian Federation
Irina V. Ignatko, MD, Dr Sci Med, Prof., Corresponding Member of RAS.
Scopus Author ID: 15118951800
WoS ResearcherID: H-2442-2018
eLibrary SPIN-code: 8073-1817
8 bldg. 2, Trubetskaya Str., Moscow 119048
I. A. Snimshchikova
Turgenev Orеl State University
Russian Federation
Russian Federation
Irina A. Snimshchikova, MD, Dr Sci Med, Prof.
95 Komsomolskaya Str., Orеl 302026
K. R. Bakhtiyarov
Sechenov University
Russian Federation
Russian Federation
Kamil R. Bakhtiyarov, MD, Dr Sci Med, Prof.
Scopus Author ID: 57208396965
eLibrary SPIN-code: 4820-1340
8 bldg. 2, Trubetskaya Str., Moscow 119048
A. S. Zueva
Sechenov University
Russian Federation
Russian Federation
Alina S. Zueva.
Scopus Author ID: 59132162700
WoS ResearcherID: JWO-2945-2024
eLibrary SPIN-code: 6190-4779
8 bldg. 2, Trubetskaya Str., Moscow 119048
T. D. Kapyrina
Sechenov University
Russian Federation
Russian Federation
Tatyana D. Kapyrina, MD.
Scopus Author ID: 58631437000
eLibrary SPIN-code: 8659-5885
8 bldg. 2, Trubetskaya Str., Moscow 119048
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Review
For citations:
Virivskaya E.V., Ignatko I.V., Snimshchikova I.A., Bakhtiyarov K.R., Zueva A.S., Kapyrina T.D. Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis. Obstetrics, Gynecology and Reproduction. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.640
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