Women's health in focus: contemporary challenges, therapeutic solutions and historical perspectives

This journal issue presents studies devoted to actual questions of women's health, including thrombophilia impact on pregnancy, determination of biological age in the reproductive period, and the relationship between placental pathology and thrombophilic disorders. Innovative approaches to diagnostics and treatment are considered, such as plasmapheresis in antiphospholipid syndrome, organ-preserving strategies in placenta accreta spectrum, and prospects for passive fetal monitoring using machine learning. Immune-mediated thrombotic complications, including vaccine-induced thrombotic and heparin-induced thrombocytopenia, are highlighted. Clinical cases of rare pathologies are presented, such as lipodermatosclerosis in pregnant women, complete androgen insensitivity syndrome, and laparoscopic cerclage for cervical insufficiency. The final material is dedicated to Robert Edwards historical role in the development of in vitro fertilization.

1. Antonova A.S., Khizroeva J.Kh., Bitsadze V.O., Tretyakova M.V., Makatsariya N.A., Efendieva E.R., Shatilina A.Yu., Lyadnova E.M. Genetic thrombophilia and antiphospholipid antibodies in women with early and late preeclampsia: a retrospective cohort study. [Geneticheskaya trombofiliya i antifosfolipidnye antitela u zhenshchin s rannej i pozdnej preeklampsiej: retrospektivnoe kogortnoe issledovanie]. Obstetrics, Gynecology and Reproduction. 2025;19(1):14–25. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2024.586.

2. Kudryavtseva E.V., Berezina D.A., Bazarnyi V.V., Polushina L.G., Kopenkin M.A., Troitskaya A.N., Kovalev V.V. Clinical and functional significance of determining biological age in women during the reproductive period. [Kliniko-funkcional'noe znachenie opredeleniya biologicheskogo vozrasta u zhenshchin v reproduktivnyj period]. Obstetrics, Gynecology and Reproduction. 2025;19(1):26–34. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.582.

3. Zubenko V.B., Tretyakova M.V., Kudryavtseva E.S., Kalashnikova I.S., Shatilina A.Yu., Einullaeva A.E., Blinov D.V., Ausheva S.E. Pathology of placenta placement and thrombophilia: an inconspicuous connection. [Patologiya raspolozheniya placenty i trombofiliya: neochevidnaya svyaz']. Obstetrics, Gynecology and Reproduction. 2025;19(1):35–46. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.545.

4. Kuneshko N.F., Kim V.V., Lyadnova E.M., Metkina A.R., Velieva M.N., Lazarchuk A.V., Bitsadze V.O., Tretyakova M.V., Blinov D.V. Plasmapheresis for lowering the risks of placenta-associated complications in antiphospholipid syndrome. [Snizhenie riskov placentaassociirovannyh oslozhnenij pri antifosfolipidnom sindrome s ispol'zovaniem plazmafereza]. Obstetrics, Gynecology and Reproduction. 2025;19(1):47–58. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.584.

5. Fatkullina D.A., Musin I.I., Yashchuk A.G., Gareev E.M. Surface-enhanced Raman spectroscopy as a method for diagnosing benign ovarian formations in pregnant women. [Poverhnostno-usilennaya ramanovskaya spektroskopiya kak metod diagnostiki dobrokachestvennyh obrazovanij yaichnikov u beremennyh]. Obstetrics, Gynecology and Reproduction. 2025;19(1):59–67. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.516.

6. Stepanova A.M., Plutnitskiy A.N., Gameeva E.V. Biologically active supplements overview: regulation, market trends, application, and health impact. [Obzor pishchevyh dobavok: regulirovanie, tendencii rynka, ispol'zovanie i vliyanie na zdorov'e]. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2024;17(3):396–408. (In Russ.). https://doi.org/10.17749/2070-4909/farmakoekonomika.2024.270.

7. Stepanova A.M., Plutnitskiy А.N., Gameeva E.V. Biologically active supplements: safety, efficacy, market review. [Biologicheski aktivnye dobavki: obzor rynka, bezopasnosti i effektivnosti]. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2024;17(4):558-571. (In Russ.). https://doi.org/10.17749/2070-4909/farmakoekonomika.2024.269.

8. Ivshin A.A., Vorobyova V.M., Malyshev N.A. Promising methods of prenatal diagnostics based on passive sensors and machine learning. [Perspektivnye metody prenatal'noj diagnostiki na osnove passivnyh datchikov i mashinnogo obucheniya]. Obstetrics, Gynecology and Reproduction. 2025;19(1):68–81. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.588.

9. Voronina M.D., Dolgiev D.A., Dolgieva R.A., Mirovaeva A.S., Garaeva Z.F., Ivanova Yu.K., Sarapultsev I.V., Turdieva E.I., Rakov V.A., Kuklina V.K., Manelov A.E., Khalilova K.Kh. Current state of the placenta accreta spectrum issue: prospects for organ-preserving treatment. [Sovremennoe sostoyanie voprosa placenta accreta spectrum: perspektivy organosohranyayushchego lecheniya]. Obstetrics, Gynecology and Reproduction. 2025;19(1):82–96. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2024.571.

10. Makatsariya A.D., Akinshina S.V., Vorobev A.V., Bitsadze V.O., Khizroeva J.Kh., Tretyakova M.V., Makatsariya N.A., Kalashnikova I.S., Gashimova N.R., Grigoreva K.N., Stepanov I.A., Dikareva I.M., Tatarintseva A.Yu., Lazarchuk A.V., Khisamieva A.R., Blinov D.V., Van Dreden P., Gris J.-C., Elalamy I., Gerotziafas G. Immune paradoxes of vaccine-induced thrombotic thrombocytopenia (VITТ), heparin-induced thrombocytopenia (HIT) and thrombosis: from general mechanisms to the unique VITТ and HIT course. [Immunnye paradoksy vakcin-inducirovannoj tromboticheskoj trombocitopenii (VITT), geparin-inducirovannoj trombocitopenii (GIT) i trombozov: ot obshchih mekhanizmov k unikal'nomu techeniyu VITT i GIT]. Obstetrics, Gynecology and Reproduction. 2025;19(1):97–109. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.610.

11. Blbulyan A.K., Arustamyan K.K., Manukyan L.K., Minasyan S.A., Gomtsyan G.A. Lipodermatosclerosis as a potential complication of chronic venous insufficiency. [Lipodermatoskleroz kak vozmozhnoe oslozhnenie hronicheskoj venoznoj nedostatochnosti]. Obstetrics, Gynecology and Reproduction. 2025;19(1):110–115. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.567.

12. Ivshin A.A., Pogodin O.O., Shakurova E.Yu., Ldinina T.Yu., Nikitin V.S. Experience of laparoscopic transabdominal cerclage for the correction of cervical insufficiency during pregnancy: a clinical case and literature review. [Laparoskopicheskij transabdominal'nyj serklyazh dlya lecheniya istmiko-cervikal'noj nedostatochnosti pri beremennosti: klinicheskij sluchaj i obzor literatury]. Obstetrics, Gynecology and Reproduction. 2025;19(1):116–126. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.578.

13. Morkos S., Al Qasem M., Aldam M., Bhotla H.K., Meyyazhagan A., Pappuswamy M., Iskandarani F., Kouteich K., Asoliman A. An exposition on complete androgen insensitivity syndrome and a case report. [Sindrom polnoj nechuvstvitel'nosti k androgenam: klinicheskij sluchaj]. Obstetrics, Gynecology and Reproduction. 2025;19(1):127–135. (In English). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.539.

14. Abdulkadyrov S.М., Karapetyan M.U., Tugusheva R.А., Polyakova T.Е., Vorobev А.V. Robert Geoffrey Edwards – a pioneer of IVF practice. [Robert Dzheffri Edvards – pioner praktiki EKO]. Obstetrics, Gynecology and Reproduction. 2025;19(1):136–141. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.580.