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GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION

https://doi.org/10.17749/2313-7347.2015.9.1.059-062

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Abstract

Оur paper presents the study of incidence rate of genetic polymorphism of hemostasis genes and folate cycle in patients with habitual miscarriage, residing in Krasnodar region. The property of reproduction age women with habitual miscarriage in juvenile age (75 patients) was the multigene nature of trombophilia in 76.81% of cases (53 patients) from 69 patients with mutations (92% of total number of studied patients) at low percent of incidence of factor V (Leiden) and factor II (prothrombin) gene mutation. It shows that the management of pregnant women, decision on COCs and HRT administration can’t be made with testing of a limited number of the most thoroughly studied genes, considered as unconditional and strict markers of inherited thrombophilia (FV, F II, MTHFR С677Т).

About the Authors

A. S. Adamchik
Kuban State Medical University of the Ministry of Health of Russia, Moscow
Russian Federation
Professor, MD, Head of the Department of Internal Medicine Propaedeutics Medical University


D. I. Panchenko
Kuban State Medical University of the Ministry of Health of Russia, Moscow
Russian Federation
Assistant of the Department of Internal Medicine Propaedeutics Medical University


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For citation:


Adamchik A.S., Panchenko D.I. GENETIC RISK FACTORS OF TROMBOPHILIA IN WOMEN OF REPRODUCTIVE AGE RESIDING IN KRASNODAR REGION. Obstetrics, Gynecology and Reproduction. 2015;9(1):59-62. (In Russ.) https://doi.org/10.17749/2313-7347.2015.9.1.059-062

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)