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Risks of venous thromboembolic complications in related to combined oral contraceptives

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.207

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Abstract

Hormonal contraception is the most popular and effective reversible method for preventing unwanted pregnancy exerting multiple prophylactic and therapeutic effect along with contraceptive activity. The main adverse coupled to combined oral contraceptives (COCs) is its impact on the hemostasis and increased risk of venous thromboembolic complications. A great evolutionary path has been travelled after beginning application of hormonal contraception to reduce dose of its estrogen component and improving quality of gestagen component. Nevertheless, thrombotic complications related to COCs use still remain a pressing issue not only due to disease severity and high mortality rate from pulmonary embolism (PE), but also due to the difficulties in its timely diagnostics. Here we describe a clinical case of a 19-year-old patient suffering from vena cava inferior thrombosis complicated by PE after using COCs.

About the Authors

K. A. Gabelova
Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation
Russian Federation

Karina A. Gabelova – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Neonatology

6–8 Lev Tolstoy Str., Saint Petersburg 197022



N. A. Shabanova
Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation
Russian Federation

Nadezhda A. Shabanova – MD, PhD, Assistant, Department of Obstetrics, Gynecology and Neonatology

6–8 Lev Tolstoy Str., Saint Petersburg 197022



V. F. Bezhenar
Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation
Russian Federation

Vitaly F. Bezhenar – MD, Dr Sci Med, Professor, Head of the Department of Obstetrics, Gynecology and Neonatology; Chief External Expert in Obstetrics and Gynecology of the Health Committee of Saint Petersburg

6–8 Lev Tolstoy Str., Saint Petersburg 197022



E. E. Zvartau
Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation
Russian Federation

Edvin E. Zvartau – MD, Dr Sci Med, Professor, Director of Valdman Institute of Pharmacology, Head of the Department of Pharmacology

6–8 Lev Tolstoy Str., Saint Petersburg 197022



Yu. A. Akishina
Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation
Russian Federation

Yulia A. Akishina – 4th year Student

6–8 Lev Tolstoy Str., Saint Petersburg 197022



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For citations:


Gabelova K.A., Shabanova N.A., Bezhenar V.F., Zvartau E.E., Akishina Yu.A. Risks of venous thromboembolic complications in related to combined oral contraceptives. Obstetrics, Gynecology and Reproduction. 2021;15(6):777-787. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.207

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