Obstetrics, Gynecology and Reproduction

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Vol 7, No 4 (2013)


6-10 329
One of the dominant clinical symptoms of adenomyosis is chronic pelvic pain . Chronic pelvic pain is recurrent or persistent pain that bothers patient less than 6 months. The aim of the study was to determine the clinical informativeness use of oncological markers CA-125 and NOT-4 in blood serum of women with pelvic pain caused by
adenomyosis. In the present study included 63 patients adenomyosis – as a core group, and 30 apparently healthy women of reproductive age as a comparison group. Indicators CA-125 were higher in patients in the second subgroup with moderately severe pain syndrome, and the average at the time of treatment amounted to 45-63 U/ml, P<0.001), but on the second day of the menstrual cycle indicators again increased and averaged 54-70 U/ml ,and also significantly (P<0.001) decreased in the study after the end of the regular menstruation( 1st-2nd dry day after menstruation in the framework of the first phase of the menstrual cycle and averaged 42-60 U/ml compared with the comparison group apparently healthy women-8.9 IU/ml Conclusion , the evidence suggests that women with pelvic pain syndrome adenomyosis is the place to co-proliferative endometrial pathology. And in these cases increasyse the sensitivity of the above serological markers. The use of two markers (NOT-4 and CA-125) has a more accurate diagnostic value to identify the process of malignization in the reproductive organs, and it is important for differential diagnosis of hyperplastic processes, and for early diagnosis of endometrial adenocarcinoma.
11-14 328
Differencial diagnostics of simple, complex and atypical hyperplasia and endometrial cancer(SEH, CEH, AEH, EC) presents a number of difficulties which often lead to a different interpretation of the same histologic samples. The
aim: to evaluate the ability of computer morphometry(CM) used in case of endometrial hyperplasia. Material: 36 patients, including 12 patients with SEH, 11 patients with CEH, 7 patients with AEH and 5 patients with EC. Method of ImaScope
Color morphometric programme. Conclusion: morphometric changes that occur in case of endometrial hyperplasia expressed in quantitative terms are more varied than their schematic definition in modern classification which in its turn may be the cause of the discrepanies in diagnoses.
15-19 318
There is a non-diminishing interest in the assessment of the blood-brain barrier (BBB) resistance and prediction of the severity and outcomes of the perinatal hypoxic-ischemic lesion of the CNS using the analysis of concentration of neuron-specific proteins in biological fluids. This defines the objective of our study – to evaluate the dynamics of serum neuron- specific enolase (NSE) concentration over a 6-month period of life in infants with cerebral ischemia using patient stratification according to their gestational age. Materials and Methods. 49 infants with the perinatal hypoxicischemic lesion of the CNS and gestational age between 32 and 41 weeks have been examined. 28 healthy term babies comprised the control group. For comparison patients were divided into the following groups: based on the 1-minute Apgar score: 1-3 scores (group А, 1-3), 4-6 scores (group А, 4-6) and 7-9 scores (group А, 7-9); based on their gestational age (GA): GA of 32-33 weeks, GA of 34-36 weeks and GA of 37-40 weeks; babies with the intra-ventricular hemorrhages (IVH group) and periventricular leukomalacia (PVL). Serum NSE levels were measured quantitatively using the enzyme immunoassay (EIA). Results. A significant increase of serum NSE levels was found in groups А 1-3, А 4-6
and А 7-9 one week postpartum as compared to the control group. Over the whole observation period serum NSE concentration showed strong correlation with the severity of perinatal hypoxic-ischemic lesion of the CNS which was reflected in the Apgar score. Both during postpartum week one and further on the serum NSE levels were significantly
higher in group GA 32-33 as compared to groups GA 34-36 and GA 37-41, as well as the control group. Starting from postpartum week one, serum NSE levels in the PVL group were significantly lower than in the IVH group. There was a delayed increase of serum NSE levels at postpartum week 4. Conclusion. The results obtained confirm the ongoing
long-term abnormal BBB permeability for NSE after the perinatal hypoxic-ischemic lesion of the CNS which reflects the chronic course of a given pathology. These changes are more pronounced in babies of lower gestational age.


20-24 355
In the literature review presents the status of the study of the problem of bacterial vaginosis during and outside of pregnancy, provides criteria of diagnostics and differential diagnostics, standards of treatment and prevention opportunities.
25-31 270
An analysis of literature data is given regarding the role of different types of therapy used for the treatment of threatened preterm labor including the efficacy and safety of such treatments.
32-34 378
The problem of genital tuberculosis is very actual. Special attention deserves an increase the number of TB patients, aged 25-34 years – the age of peak fertility. The period from the beginning of the disease to establish a correct diagnosis is often reaches 5-20 years. Many years the patient can have only one complaint – infertility. The relevance of genital tuberculosis modern diagnostics is determined by the mismatch objective of increasing the prevalence of pulmonary tuberculosis and subjective low prevalence of urogenital tuberculosis associated with the complexity of its detection and treatment outcomes. Among the modern methods of immunodiagnostics tuberculosis, great importance
is the identification of specific antibodies to Mycobacterium tuberculosis in the peripheral blood by enzyme immunoassay and immunochromatographic rapid test.
35-43 479
Metabolic syndrome is commonly found among women of reproductive age and represents a risk factor for various pregnancy complications. The presence of genetically determined hypofibrinolysis in women with metabolic syndrome, along with other forms of thrombophilia, determines the implantation failure and abnormalities in trophoblast
invasion and placentation. Subsequently, this may cause the fetal loss syndrome and other pregnancy complications.

ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)