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Thrombophilia in the pathogenesis of fetal growth retardation

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.223

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Abstract

Fetal growth retardation (FGR) is a complication of pregnancy that determines perinatal morbidity and mortality. It is a complex and multifaceted medical problem that does not lose its relevance. Impaired fetal development and delayed growth result from various etiopathogenesis of pathological processes occurring in the "mother–placenta–fetus" interface. Thrombophilia is one of the factors that can initiate disturbed placental function and the utero-placental blood flow. Here we describe the clinical FGR variants and etiopathogenetic factors of developing this complication of pregnancy (placental, maternal, and fetal). Special attention is paid to genetic and acquired thrombophilia (due to the circulation of antiphospholipid antibodies) and their role in development of such complication of pregnancy.

About the Authors

E. A. Orudzhova
Maternity Hospital № 1 – Branch of Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department
Russian Federation

Esmira A. Orudzhova – MD, Head of Outpatient Medical Care Center

2/44 Salyama Adilya Str., Moscow 123423



N. A. Samburova
Sechenov University
Russian Federation

Natalia V. Samburova – MD, PhD, Associate Professor, Department of Pathophysiology, Institute of Clinical Medicine

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



E. V. Anichkova
Sechenov University
Russian Federation

Elizaveta V. Anichkova – 5th year Student, International School «Medicine of the Future»

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



K. E. Gotsiridze
Chachava Clinic
Georgia

Ketevan E. Gotsiridze – MD, Obstetrician-Gynecologist, Head of the Center for Reproductive Health

38 Merab Kostava Str., Tbilisi 0179

 



V. O. Bitsadze
Sechenov University
Russian Federation

Viktoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 6506003478. Researcher ID: F-8409-2017.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

 



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For citation:


Orudzhova E.A., Samburova N.A., Anichkova E.V., Gotsiridze K.E., Bitsadze V.O. Thrombophilia in the pathogenesis of fetal growth retardation. Obstetrics, Gynecology and Reproduction. 2021;15(2):189-200. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.223

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)