ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY
Abstract
Studying of a role of gene polymorphisms during gestational process at pregnant women with obesity was the purpose. Selection 175 women with threat of interruption of pregnancy aged from 20 till 41 year (120 (68.6%) made women with an excess weight (the main group), 55 (31.4%) – with the normal body weight (group of comparison)).
Except the researches regulated by Orders of the Ministry of health care of Ukraine research of 12 genetic options of polymorphism of genes of a trombofiliya, and also polymorphism of a gene angiotenzinogena-1 (AGT Thr174Met), a gene angiotenzinogena-2 (AGT Met235Thr), mutations-1 of a sintaza of an oxide of nitrogen 3 (NOS3 C786T) is conducted by method of polimerazny chain reaction. Reliable correlation communication between existence of excess weight and arterial hypertension, a hyper coagulative syndrome, a mutation of factors of a fibrillation of F5 Leiden, F7, PAI gene-1, MTR gene is revealed: 2756 – B12-dependent methionine-sintazy. Direct correlation between polymorphism of genes of arterial hypertension and complications of the second half of pregnancy and childbirth is revealed. Thus it is proved that obesity and genetically caused trombofiliya are major factors of risk of development of complications of a gestation and the tromboembolicheskikh of complications.
Except the researches regulated by Orders of the Ministry of health care of Ukraine research of 12 genetic options of polymorphism of genes of a trombofiliya, and also polymorphism of a gene angiotenzinogena-1 (AGT Thr174Met), a gene angiotenzinogena-2 (AGT Met235Thr), mutations-1 of a sintaza of an oxide of nitrogen 3 (NOS3 C786T) is conducted by method of polimerazny chain reaction. Reliable correlation communication between existence of excess weight and arterial hypertension, a hyper coagulative syndrome, a mutation of factors of a fibrillation of F5 Leiden, F7, PAI gene-1, MTR gene is revealed: 2756 – B12-dependent methionine-sintazy. Direct correlation between polymorphism of genes of arterial hypertension and complications of the second half of pregnancy and childbirth is revealed. Thus it is proved that obesity and genetically caused trombofiliya are major factors of risk of development of complications of a gestation and the tromboembolicheskikh of complications.
About the Authors
Z. M. Dubossarskaya
Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine (Dnepropetrovsk, Ukraine)
Russian Federation
Russian Federation
Yu. M. Duka
Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine (Dnepropetrovsk, Ukraine)
Russian Federation
Russian Federation
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Review
For citations:
Dubossarskaya Z.M., Duka Yu.M. ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY. Obstetrics, Gynecology and Reproduction. 2014;8(4):6-11. (In Russ.)
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