Один из трендов оксидативной протекции в программах экстракорпорального оплодотворения

В литературном обзоре представлены результаты экспериментальных и клинических международных исследований о патогенезе действия мелатонина при использовании в программах вспомогательных репродуктивных технологий, освещаются различные точки зрения его биологического эндогенного действия как регулятора циркадных ритмов: с одной стороны, рассматривается ингибирующее влияние мелатонина на пульсирующую секрецию гонадотропин-рилизинг гормона, за счет чего достигается контрацептивный эффект; с другой стороны, обсуждаются данные о его способности индуцировать секрецию хорионического гонадотропина, обеспечивая процесс овуляции. В обзоре представлены данные о мелатонине как о высокоактивном антиоксиданте. При использовании мелатонина в качестве метаболической дотации в программах экстракорпорального оплодотворения (ЭКО) прослеживается его положительное влияние на морфологию ооцитов, качество оплодотворения и деление эмбрионов. В настоящем обзоре приведены результаты исследований влияния мелатонина на качество оплодотворения и деления эмбрионов при условии его добавления в культуральную среду. Достигнутые эффекты имели дозазависимый характер. С учетом обобщенных данных добавление экзогенного мелатонина может являться новой стратегией персонифицированного подхода по улучшению исходов программ ЭКО. Эффективность его применения должна быть дополнительно исследована и рассмотрена к внедрению в рамках прегравидарной подготовки.

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