Gestational trophoblastic disease: risk factors, current methods of diagnostics and treatment
https://doi.org/10.17749/2313-7347.2018.12.2.048-054
Abstract
The article presents current data on diagnosis and treatment of patients with gestational trophoblastic disease, risk factors and their role in pathology development are also analyzed.
About the Authors
A. G. Solopova
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Solopova Antonina Grigorievna – MD, Professor, Department of Obstetrics and Gynecology, Faculty of Clinical and Preventive Medicine
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004
A. D. Makatsariya
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Makatsariya Alexander Davidovich – MD, Corresponding Member of RAS, Professor, Head of Department of Obstetrics and Gynecology, Faculty of Clinical and Preventive Medicine
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004
A. Е. Solopova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Solopova Alina Evgen’evna – MD, Leading Researcher, Department of Radiology
4, ul. academika Oparina, Moscow, 117997
Е. S. Egorova
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Egorova Elena Sergeevna – PhD, Associate Professor, Department of Obstetrics and Gynecology, Faculty of Clinical and Preventive Medicine
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004
V. S. Moskvichyova
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Moskvichyova Viktoria Sergeevna – Graduate Student, Faculty of Pediatrics
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004
References
1. Fulop V., Mok S.C., Berkowitz R.S. Molecular biology of gestational trophoblastic neoplasia: a review. J Reprod Med. 2004; 49 (6): 415-22.
2. Fisher R.A., Lavery S.A., Carby A. et al. What a difference an egg makes. Lancet. 2011; 378 (9807): 1974.
3. Galton V.A., Ingbar S.H., Jimenez-Fonseca J. et al. Alterations in thyroid hormone economy in patients with hydatidiform mole. J Clin Invest. 1971; 50: 1345-54.
4. Amir S.M., Osathanondh R., Berkowitz R.S. et al. Human chorionic gonadotropin and thyroid function in patients with hydatidiform mole. Am J Obstet Gynecol. 1984; 150: 723-8.
5. Osathanondh R., Berkowitz R.S., de Cholnoky C. et al. Hormonal measurements in patients with teca lutein cysts and gestational trophoblastic disease. J Reprod Med. 1986; 31: 179-83.
6. Berkowitz R.S., Goldstein D.P., Bernstein M.R. Laparoscopy in the management of gestational trophoblastic neoplasms. J Reprod Med. 1980; 24: 261-64.
7. Szulman A.E., Surti U. The clinicopathologic profile of the partial hydatidiform mole. Obstet Gynecol. 1982; 59 (5): 597-602.
8. Berkowitz R.S., Goldstein D.P., Bernstein M.R. Natural history of partial molar pregnancy. Obstet Gynecol. 1985; 66 (5): 677-81.
9. Genest D.R., Dorfman D.M., Castrillon D.H. Ploidy and imprinting in hydatidiform moles. Complementary use of flow cytometry and immunohistochemistry of the imprinted gene product p57KIP2 to assist molar classification. J Reprod Med. 2002; 47 (5): 342-6.
10. Hussein M.R. Analysis of p53, BCL-2 and epidermal growth factor receptor protein expression in the partial and complete hydatidiform moles. Exp Mol Pathol. 2009; 87 (1): 63-9.
11. Halperin R., Peller S., Sandbank J. et al. Expression of the p53 gene and apoptosis in gestational trophoblastic disease. Placenta. 2000; 21 (1): 188-91.
12. Lurain J.R. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010; 203 (6): 531-9.
13. Benson C.B., Genest D.R., Bernstein M.R. et al. Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol. 2000; 16: 188-91.
14. Shaaban A.M., Rezvani M., Haroun R.R. et al. Gestational Trophoblastic Disease: Clinical and Imaging Features. Radiographics. 2017; 37 (2): 681-700.
15. Berkowitz R.S., Tuncer Z.S., Bernstein M.R., Goldstein D.P. Management of gestational trophoblastic diseases: subsequent pregnancy experience. Semin Oncol. 2000; 27 (6): 678-85.
16. Soper J.T. Surgical therapy for gestational trophoblastic disease. J Reprod Med. 1994; 39: 168.
17. Goldstein D.P., Berkowitz R.S. Prophylactic chemotherapy of complete molar pregnancy. Semin Oncol. 1995; 22: 157-60.
18. Berkowitz R.S., Goldstein D.P., Marean A.R. et al. Oral contraceptives and postmolar trophoblastic disease. Obstet Gynecol. 1981; 58 (4): 474-7.
19. Felmate C.M., Batorfi J., Fulop V. et al. Human chorionic gonadotropin follow-up in patients with molar pregnancy: A time for reevaluation. Obstet Gynecol. 2003; 101: 732-6.
20. Wolfberg A.J, Felmate C., Goldstein D.P.et al. Low risk of relapse after achieving undetectable hCG levels in women with complete molar pregnancy. Obstet Gynecol. 2004; 104: 551-4.
21. Growdon W.B., Wolfberg A.J, Felrmate C.M. et al. Post evacuationh CG levels and risk of gestational trophoblastic neoplasia among women with partial molar pregnancies. J Reprod Med. 2006; 51: 871-4.
22. Schmitt C., Doret M., Massardier J. et al. Risk of gestational trophoblastic neoplasia after hCG normalization according to hydatidiform type. Gynecol Oncol. 2013; 130: 86-9.
23. Eagles N., Sebire N.J., Short D. et al. Risk of recurrent molar pregnancies following complete and partial hydatidiform moles. Hum Reprod. 2015; 30: 1168-71.
Review
For citations:
Solopova A.G., Makatsariya A.D., Solopova A.Е., Egorova Е.S., Moskvichyova V.S. Gestational trophoblastic disease: risk factors, current methods of diagnostics and treatment. Obstetrics, Gynecology and Reproduction. 2018;12(2):48-54. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.2.048-054
Views:
966
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
