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CLINICAL BASIS OF DIPYRIDAMOL USE IN OBSTETRIC PRACTICE

https://doi.org/10.17749/2313-7347.2017.11.2.045-048

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Abstract

The currently accepted role of hemostatic disorders (antiphospholipid syndrome, genetic thrombophilia) in the pathogenesis of frequent obstetric complications (preeclampsia, premature placental abruption, feto-placental insufficiency, recurrent miscarriage) revolutionized the prevention and treatment of these pregnancy-associated abnormalities. An increasing number of direct and indirect anticoagulants have been introduced into clinical practice. The present review addresses the mechanisms of action of dipyridamole, an antiaggregant medication commonly used in obstetrics. In addition to its antiplatelet activity, dipyridamole is also known for other pharmacological effects, including the antioxidant and endothelioprotective activities.

About the Authors

S. V. Akinshina
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation

Akinshina Svetlana Vladimirovna - PhD, research associate, Department of Obstetrics and Gynecology, Faculty of Preventive Medicine 

Address: ul. Trubetskaya, 8, str. 2, Moscow, Russia, 119991. ecology, Faculty of Preventive Medicine



V. O. Bitsadze
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation

Bitsadze Victoria Omarovna - MD, Professor, Department of Obstetrics and Gynecology, Faculty of Preventive Medicine 

Address: ul. Trubetskaya, 8, str. 2, Moscow, Russia, 119991. ecology, Faculty of Preventive Medicine



A. D. Makatsariya
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation

Makatsariya Aleksandr Davidovich - MD, Professor, corresponding member of the Russian Academy of Sciences, Head of Department of Obstetrics and Gynecology, Faculty of Preventive Medicine 

Address: ul. Trubetskaya, 8, str. 2, Moscow, Russia, 119991. ecology, Faculty of Preventive Medicine



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For citation:


Akinshina S.V., Bitsadze V.O., Makatsariya A.D. CLINICAL BASIS OF DIPYRIDAMOL USE IN OBSTETRIC PRACTICE. Obstetrics, Gynecology and Reproduction. 2017;11(2):45-48. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.2.045-048

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)