ASSESSMENT OF BIOCHEMICAL PARAMETERS IN PREGNANT WOMEN WITH METABOLIC DISORDERS: A COMPARATIVE STUDY
https://doi.org/10.17749/2313-7347.2017.11.2.012-017
Abstract
Objective: еvaluation of lipid metabolism, lipid peroxidation (LPO) and antioxidant system (AOS) in pregnant women with various metabolic disorders. Materials and methods. This study was conducted in pregnant women with no known metabolic disorder, in those with the symptoms of metabolic syndrome and in women with gestational diabetes mellitus. Results. We found evidence for activation of LPO in pregnant women with impaired glucose metabolism; the LPO developed on the background of decreased activity of AOS enzymes. As proposed, the active oxygen species and the LPO products caused a reduction in the level of nitric oxide (NO) - a major vasodilating substance. The resulting vasoconstriction might lead to hypoxia with its negative impact on fetus development. Conclusion. Based on the obtained data we recommend using the parameters of LPO-AOS and the markers of endothelial NO-production as additional laboratory tests in pregnant women with gestational diabetes mellitus and metabolic syndrome.
About the Authors
S. G. Dzugkoev
Institute of Biomedical Research - branch of Federal Research Center «Vladikavkaz Scientific Center, Russian Academy of Sciences»
Russian Federation
Russian Federation
Dzugkoev Sergey Gavrilovich - MD, Head of Pathobiochemistry Department
Address: ul. Pushkinskaya, 47, Vladikavkaz, Russia, 362025
A. I. Tedtoeva
Maternity Hospital № 1, Health Ministry of North Ossetia-Alania Republic
Russian Federation
Russian Federation
Tedtoeva Angelika Iraklievna - PhD, Head physician
Address: ul. Dzerzhinsky, 32, Vladikavkaz, Russia, 362003.
F. S. Dzugkoeva
Institute of Biomedical Research - branch of Federal Research Center «Vladikavkaz Scientific Center, Russian Academy of Sciences»
Russian Federation
Russian Federation
Dzugkoeva Fira Solomonovna - MD, Professor, leading researcher of Pathobiochemistry Department
Address: ul. Pushkinskaya, 47, Vladikavkaz, Russia, 362025
I. V. Mozhaeva
Institute of Biomedical Research - branch of Federal Research Center «Vladikavkaz Scientific Center, Russian Academy of Sciences»
Russian Federation
Russian Federation
Mozhaeva Irina Victorovna - junior researcher of Pathobiochemistry Department
Address: ul. Pushkinskaya, 47, Vladikavkaz, Russia, 362025
O. I. Margieva
Institute of Biomedical Research - branch of Federal Research Center «Vladikavkaz Scientific Center, Russian Academy of Sciences»
Russian Federation
Russian Federation
Margieva Olga Ivanovna - junior researcher of Pathobiochemistry Department
Address: ul. Pushkinskaya, 47, Vladikavkaz, Russia, 362025
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Review
For citations:
Dzugkoev S.G., Tedtoeva A.I., Dzugkoeva F.S., Mozhaeva I.V., Margieva O.I. ASSESSMENT OF BIOCHEMICAL PARAMETERS IN PREGNANT WOMEN WITH METABOLIC DISORDERS: A COMPARATIVE STUDY. Obstetrics, Gynecology and Reproduction. 2017;11(2):12-17. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.2.012-017
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