ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY
https://doi.org/10.17749/2313-7347.2017.11.1.014-018
Abstract
The aim was to study the renin-angiotensin-aldosterone system (RAAS), the level of leptin and kidney function in women with pre-eclampsia (PE) and alimentary obesity (AO).
Materials and methods. The levels of renin, angiotensin II, aldoste-rone, leptin, insulin, cortisol, β2-microglobulin, glomerular filtration rate were measured.
Results. We show that RAAS, along with a systemic inflammatory response, is a key factor in the development of pre-eclampsia and its progression. The increasing level of leptin has a direct damaging effect on the tubular system of the kidneys.
Conclusions. Stimulating the RAAS aggravates the inflammatory response and endothelial dysfunction in women with PE and AO. Elevated concen-trations of leptin in these women have a direct damaging impact on the kidney tubules.
About the Authors
A. N. Rymashevskii
Rostov state medical University
Russian Federation
Russian Federation
MD, professor, Head of the Department of Obstetrics and Gynaecology №1 Rostov State Medical University, the Ministry of Health, Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022
S. S. Tumanyan
Rostov state medical University
Russian Federation
Russian Federation
graduate student of obstetrics and gynecology №1 Rostov State Medical University, Ministry of Health of the Russian Federation. Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022
E. M. Frantsiyants
Rostov scientific research oncological Institute
Russian Federation
Russian Federation
MD, professor, Head hormonal laboratory FGBU Rostov Cancer Research Institute of the Ministry of Health. Address: ul. 14th line, 63, Rostov-on-Don, Russia, 344037
S. V. Tumanyan
Rostov scientific research oncological Institute
Russian Federation
Russian Federation
MD Professor, Department of Anesthesiology and Intensive Care, Rostov State Medical University, the Ministry of Health. Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022
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Review
For citations:
Rymashevskii A.N., Tumanyan S.S., Frantsiyants E.M., Tumanyan S.V. ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY. Obstetrics, Gynecology and Reproduction. 2017;11(1):14-18. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.1.014-018
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