ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY

A. N. Rymashevskii; S. S. Tumanyan; E. M. Frantsiyants; S. V. Tumanyan

doi:10.17749/2313-7347.2017.11.1.014-018

ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY

A. N. Rymashevskii, S. S. Tumanyan, E. M. Frantsiyants, S. V. Tumanyan

https://doi.org/10.17749/2313-7347.2017.11.1.014-018

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Abstract

The aim was to study the renin-angiotensin-aldosterone system (RAAS), the level of leptin and kidney function in women with pre-eclampsia (PE) and alimentary obesity (AO).

Materials and methods. The levels of renin, angiotensin II, aldoste-rone, leptin, insulin, cortisol, β2-microglobulin, glomerular filtration rate were measured.

Results. We show that RAAS, along with a systemic inflammatory response, is a key factor in the development of pre-eclampsia and its progression. The increasing level of leptin has a direct damaging effect on the tubular system of the kidneys.

Conclusions. Stimulating the RAAS aggravates the inflammatory response and endothelial dysfunction in women with PE and AO. Elevated concen-trations of leptin in these women have a direct damaging impact on the kidney tubules.

Keywords

Pre-eclampsia, obesity, leptin, renin-angiotensin-aldosterone system, kidneys.

About the Authors

A. N. Rymashevskii

Rostov state medical University
Russian Federation

MD, professor, Head of the Department of Obstetrics and Gynaecology №1 Rostov State Medical University, the Ministry of Health, Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022

S. S. Tumanyan

Rostov state medical University
Russian Federation

graduate student of obstetrics and gynecology №1 Rostov State Medical University, Ministry of Health of the Russian Federation. Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022

E. M. Frantsiyants

Rostov scientific research oncological Institute
Russian Federation

MD, professor, Head hormonal laboratory FGBU Rostov Cancer Research Institute of the Ministry of Health. Address: ul. 14th line, 63, Rostov-on-Don, Russia, 344037

S. V. Tumanyan

Rostov scientific research oncological Institute
Russian Federation

MD Professor, Department of Anesthesiology and Intensive Care, Rostov State Medical University, the Ministry of Health. Address: per. Nakhichevanskii, 29, Rostov-na-Donu, Russia, 344022

References

1. Okhapkin M.B., Serov V.N., Lopukhin V.O. Meditsina neotlozhnykh sostoyanii. 2007; 3 (10): 79-83.

2. Krapivina N.A., Artymuk N.V., Tachkova O.A., Kostin V.I., Likstanov M.I. Fundamental'nye issledovaniya. 2004; 4: 70-71.

3. Petunina N.A., Kuzina I.A. Ozhirenie i metabolizm. 2013; 1: 3-8.

4. Shestakova M.V. Sakharnyi diabet. 2010; 3: 14-19.

5. Linnй Y, Neovius M. Identification of women at risk of adverse weight development following pregnancy. Int J Obes (Lond). 2006; 30 (8):1234-9.

6. Misra V.K, Trudeau S. The Influence of Overweight and Obesity on Longitudinal Trends in Maternal Serum Leptin Levels During Pregnancy. Obesity. 2011; 192: 416-421.

7. Lau T., Carlsson P.O., Leung P.S. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia. 2004; 47: 240-248.

8. Ingelsson E., Pencina M.J., Tofler G.H., et al. Multimarker approach to evaluate

9. the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham offspring study. Circulation. 2007; 116: 984-992.

10. Kraus D., Jдger J., Meier B. et al. Aldosterone Inhibits Uncoupling Protein-1, Induces Insulin Resistance, and Stimulates Proinflammatory Adipokinesin Adipocytes. Horm. Metab. Res. 2005; 37: 455-459.

11. Kryachkova A.A., Savel'eva S.A., Gallyamov M.G., Shestakova M.V., Kutyrina I.M. Rol' ozhireniya v porazhenii pochek pri metabolicheskom sindrome. Nefrologiya i dializ. 2010; 1 (12): 34-38.

12. Papafragkaki D.K., George T. Obesity and renal disease: A possible role of leptin. Hormones. 2005; 4 (2): 90-95.

13. Chdek J., Adamczak M., Nieszporek T. et al. Adipose Tissue as an Endocrine Organ-A Nephrologistists Perspective. Obesity and kidney. 2006; 151: 70-90.

For citation:

Rymashevskii A.N., Tumanyan S.S., Frantsiyants E.M., Tumanyan S.V. ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY. Obstetrics, Gynecology and Reproduction. 2017;11(1):14-18. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.1.014-018