ОРАЛЬНЫЕ АНТИКОАГУЛЯНТЫ ПРЯМОГО ДЕЙСТВИЯ
https://doi.org/10.17749/2313-7347.2015.10.1.011-025
Аннотация
В настоящее время в Европе и США разрешено применение некоторых антикоагулянтов прямого действия (АКПД), а именно апиксабана, ривароксабана и дабигартана этексилата для лечения различных тромбоэмболических заболеваний. Они являются альтернативой имеющему низкий молекулярный вес гепарину при послеоперационном лечении в качестве профилактики и терапии венозной тромбоэмболии (ВТЭ), а также антагонистами витамина K при более длительной терапии. При приеме АКПД не требуется планового контроля свертываемости крови, однако рекомендуется больным, страдающим почечной недостаточностью, при острых кровотечениях, передозировках или экстренной хирургии. Если кровотечение угрожает жизни, то во избежание антикоагулянтного эффекта АКПД можно попробовать применение без показаний концентрата протромбинового комплекса или активированного протромбинового комплекса. АКПД дает важные преимущества для краткосрочной профилактики ВТЭ у пациентов, которым была сделана хирургическая замена бедра или колена, а при длительном лечении ВТЭ и для профилактики инсульта у больных с фибрилляцией желудочков по сравнению с традиционными средствами, включая снижение интенсивности опасных типов кровотечений.
Об авторах
И. Tзоран
Отделение гематологии и трансплантации костного мозга, Медицинский городок Рамбам, Хайфа, Израиль
Центр внутренних болезней, Медицинский городок Рамбам, Хайфа, Израиль
Медицинский факультет им. Брюса Раппапорта, Технион, Хайфа, Израиль
Россия
Россия
д.м.н., заместитель директора Центра внутренних болезней медицинского городка Рамбам. Адрес: а\я 9602, Хайфa 31096, Израиль. Тел.: +(972)47772029. Факс: +(972)47772343
Б. Бреннер
Отделение гематологии и трансплантации костного мозга, Медицинский городок Рамбам, Хайфа, Израиль
Медицинский факультет им. Брюса Раппапорта, Технион, Хайфа, Израиль
Россия
Россия
проф., Отделение гематологии и трансплантации костного мозга, Медицинский городок Рамбам, Хайфа, Израиль, Медицинский факультет им. Брюса Раппапорта, Технион, Хайфа, Израиль
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Рецензия
Для цитирования:
Tзоран И., Бреннер Б. ОРАЛЬНЫЕ АНТИКОАГУЛЯНТЫ ПРЯМОГО ДЕЙСТВИЯ. Акушерство, Гинекология и Репродукция. 2016;10(1):11-25. https://doi.org/10.17749/2313-7347.2015.10.1.011-025
For citation:
Tzoran I., Brenner B. DIRECT ORAL ANTICOAGULANTS. Obstetrics, Gynecology and Reproduction. 2016;10(1):11-25. (In Russ.) https://doi.org/10.17749/2313-7347.2015.10.1.011-025
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