Preview

Obstetrics, Gynecology and Reproduction

Advanced search

TROMBOCYTE PARAMETRS IN NORMAL PREGNANCY AND GESTOSIS

Full Text:

Abstract

The study of thrombocyte parameteres in healthy women in reproductive age (n=29) and pregnant women in third trimester with normal ongoing pregnancy (n=20) and with gestosis (n=38) was conducted. The relative breadth of distribution by volume(PDW, fl), share of cells with volume more than 12 fl (P-LCR, %) and relative quantity of immature thrombocytes (IPF, %) were investigated. It was established that significant decrease of thrombocytes number takes place in pregnants compared to healthy women of reproductive age. The most significant changes were observed in women with moderate and severe gestosis. The reliable increase of relative breadth of thrombocyte distribution by volume in this group of pregnant women was also detected. This may be associated with growth of number of big and, probably, immature and functionally active thrombocytes. Thus, increase in number of immature thrombocytes, occurring in response to endothelium lesions as a part of gestosis pathogenesis, may serve as adaptation marker of thrombopoeisis system.

About the Authors

V. M. Pogorelov
FSBE Centre of Hematology, Ministry of Health and Social development, Moscow
Russian Federation


G. I. Kozinec
FSBE Centre of Hematology, Ministry of Health and Social development, Moscow
Russian Federation


I. O. Makarov
First MSMU named after Sechenov I.M., Moscow
Russian Federation


A. V. Tochenov
First MSMU named after Sechenov I.M., Moscow
Russian Federation


O. V. Rykunova
First MSMU named after Sechenov I.M., Moscow
Russian Federation


References

1. Блощинская И.А. Функциональное состояние сосудистого эндотелия и нарушения микроциркуляции при беременности, осложненной гестозом и влияние на них нормобарической гипокситерапии: автореф. дисс. докт. мед. наук. Хабаровск, 2003; 260 с.

2. Бурячковская Л.И. Гетерогенность тромбоцитов человека и животных. Связь морфологических особенностей с функциональным состоянием: автореф. дисс. докт. биол. наук. М. 2007; 217 с.

3. Мозговая Е.В., Малышева О., Иващенко Т.Э., Айламазян Э.К. Эндотелиальная дисфункция при гестозе: метод. реком. Н-Л. 2003; 32 с.

4. Погорелов В.М., Бескоровайнова В.Ю., Лазаренко М.И., Гемджян Э.Г., Уртаев Б.М, Шишканова З.Г., Точенов А.Н., Козинец Г.И. Незрелые тромбоциты в периферической крови доноров до и после тромбоцитафереза. Вестник службы крови. 2011; 2: 29-33.

5. Савельева Г.М., Кулаков В.И., Серов В.Н., Стрижаков А.Н., Шалина Р.И., Мурашко Л.Е. Современные подходы к диагностике, профилактике и лечению гестоза: метод. реком. М. 1999; 24 с.

6. Салахеева P.C., Понукалина Е.В., Глухова Т.Н., Чеснокова Н.П. Динамика изменений показателей периферической крови у беременных с гестозом различной степени тяжести. Медицинские науки, фундаментальные исследования. 2006; 10: 20-23.

7. Шилин Д.Е. Первичная профилактика преэклампсии кальцием и витамином D (с позиций акушерства, основанного на доказательствах). Гинекология. 2011; 4: 4-11.

8. Barton J.R., Sibai B.M. Diagnosis and management of hemolysis, elevated liver enzymes, and low platelets syndrome. Clin. Perinatol. 2004; 31 (4): 807-833.

9. Briggs C., Harrison P., Grant D., Staves J., Machin S.J. New quantitative parameters on a recently introduced automated blood cell counter -the XE 2100TM. Clinical & Laboratory Haematology. 2000; 22 (6): 345-350.

10. Briggs C., Kunka S., Hart D., Oguni S., Machin S.J. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. British Journal of Haematology. 2004; 126 (1): 93-99.

11. Butkiewicz A.M., Kemona H., Dymicka-Piekarska V., Matowicka-Karna J., Radziwon P., Lipska A. Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men. Thrombosis Research. 2006; 118 (2): 199-204.

12. Buttarello M., Plebani M. Automated Blood Cell Counts State of the Art. Am. J. Clin. Pathol. 2008; 130 (1): 104-116.

13. Consolini R., Calleri A., Bengala C., Legitimo A., Conte P.F. Evaluation of thrombopoiesis kinetics by measurement of reticulated platelets and CD34+ cell subsets in patients with solid tumors following high dose chemotherapy and autologous peripheral blood progenitor cell support. Haematologica. 2001; 86 (9): P. 959-964.

14. Giles C., Ingles T.C.M. Thrombocytopenia and macrothrombocytosis in gestational hypertension. British J. Obstetrics & Gynecology. 1981; 88 (11): 1115-1119.

15. Ingram M., Coopersmith A. Reticulated platelets following acute blood loss. British Journal of Haematology. 1969; 17 (3): 225-229.

16. Kaito K., Otsubo H., Usui N., Yoshida M., Tanno J., Kurihara E., Matsumoto K., Hirata R., Domitsu K., Kobayashi M. Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. British Journal of Haematology. 2005; 128 (1): 698-702.

17. Karim R., Sacher R.A. Thrombocytopenia in pregnancy. Current Hematology Report. 2004; 3 (2): 128-133.

18. Levy J.A., Murphy L.D. Thrombocytopenia in Pregnancy. J. American Board Family Practice. 2002; 15 (4): 290-297.

19. Maconi M., Casolari B., Collell M., Cenci A.M. Reference range of platelet count in normal pregnancy using Sysmex SE-9500. Sysmex J. Int. 2002; 12 (1): 30-33.

20. McCrae K.R., Samuels P., Schreiber A.D. Pregnancy-associated thrombocytopenia: pathogenesis and management. Blood. 1992; 80 (11): 2697-2714.

21. Onisai M., Vladareanu A.-M., Bumbea H., Ciorascu M., Pop C., Andrei C., Nicolescu A., Voican I., Vasilescu S., Visan L., Adrian I.I., Horhoianu V., Marinescu B., Vladareanu R. A study of the hematological picture and of platelet function in preeclampsia -report of a series of cases. Maedica J. Clin. Medicine. 2009; 4 (4): 326-337.

22. Pogorelov V.M., Beskorovainova V.Ju., Chanieva M.I., Dyagileva O.A., Naumova I.N., Skedina M.A. Periodic acid-Schiff (PAS) staining of immature platelets in donors. Platelets. 2012; 23 (1): 51-59.

23. Rinder H.M., Bonan J.L., Anandan S., Rinder C.S., Rodrigues P.A., Smith B.R. Noninvasive measurement of platelet kinetics in normal and hypertensive pregnancies. Am. J. Obstet. Gynecol. 1994; 170 (1, Pt. 1.): 117-122.

24. Sibai B.M. Imitators of severe pre-eclampsia/eclampsia. Clin. Perinatol. -2004; 31 (4): 835-852.

25. Stohlawetz P., Stiegler G., Jilma B., Dettke M., Hocker P., Pancer S. Measurment of the levels of reticulated platelets after platelepheresis to monitor activity of thrombopoiesis. Transfusion. 1998; 38 (5): 454-458.


For citation:


Pogorelov V.M., Kozinec G.I., Makarov I.O., Tochenov A.V., Rykunova O.V. TROMBOCYTE PARAMETRS IN NORMAL PREGNANCY AND GESTOSIS. Obstetrics, Gynecology and Reproduction. 2012;6(3):28-33. (In Russ.)

Views: 94


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)