TROMBOCYTE PARAMETRS IN NORMAL PREGNANCY AND GESTOSIS
Abstract
The study of thrombocyte parameteres in healthy women in reproductive age (n=29) and pregnant women in third trimester with normal ongoing pregnancy (n=20) and with gestosis (n=38) was conducted. The relative breadth of distribution by volume(PDW, fl), share of cells with volume more than 12 fl (P-LCR, %) and relative quantity of immature thrombocytes (IPF, %) were investigated. It was established that significant decrease of thrombocytes number takes place in pregnants compared to healthy women of reproductive age. The most significant changes were observed in women with moderate and severe gestosis. The reliable increase of relative breadth of thrombocyte distribution by volume in this group of pregnant women was also detected. This may be associated with growth of number of big and, probably, immature and functionally active thrombocytes. Thus, increase in number of immature thrombocytes, occurring in response to endothelium lesions as a part of gestosis pathogenesis, may serve as adaptation marker of thrombopoeisis system.
About the Authors
V. M. Pogorelov
FSBE Centre of Hematology, Ministry of Health and Social development, Moscow
Russian Federation
Russian Federation
G. I. Kozinec
FSBE Centre of Hematology, Ministry of Health and Social development, Moscow
Russian Federation
Russian Federation
I. O. Makarov
First MSMU named after Sechenov I.M., Moscow
Russian Federation
Russian Federation
A. V. Tochenov
First MSMU named after Sechenov I.M., Moscow
Russian Federation
Russian Federation
O. V. Rykunova
First MSMU named after Sechenov I.M., Moscow
Russian Federation
Russian Federation
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Review
For citations:
Pogorelov V.M., Kozinec G.I., Makarov I.O., Tochenov A.V., Rykunova O.V. TROMBOCYTE PARAMETRS IN NORMAL PREGNANCY AND GESTOSIS. Obstetrics, Gynecology and Reproduction. 2012;6(3):28-33. (In Russ.)
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