NONSPECIFIC VAGINITIS IN PREGNANTS: IS IT POSSIBLE TO TREAT WITH LACTOBACILLUS MAINTENANCE?
Abstract
Indication of combined medications with wide spectrum of action is more reasonable in treatment of nonspecific vaginitis in pregnants, taking into account frequency of combined infection. The objective of current research was to reveal the impact of complex antiinfective medication on quantity of lactobacillus in pregnant women with nonspecific vaginitis. 33 pregnant women at 18,34±1,46 weeks of gestation with different obstetric pathology were included into the study. According the results of clinical and laboratory examination patients with nonspecific vaginitis, undergoing complex therapy with Polygynax (neomicine sulfate 35000 ME+nistatine 100000 ME, additional substances-dimeticone, vitamins A, E,D, soya lecitine, aminoacides, phospholipids) were enrolled into the study. Clinical monitoring was made before treatment, at 3-4th day from therapy beginning and at the end of the therapy (13-14 day). Objective methods demonstrate normalization of clinical values, decrease in the microbic contamination in vaginal discharge. As a result of treatment with Polygynax normal vaginal microbiocenosis was restored in 78,8% of pregnant women.
About the Authors
N. V. Spiridonova
Samara State Medical University, State Budget Educational Institution of Higher Professional Training of the Ministry of Healthcare and Social Development
Russian Federation
Russian Federation
E. I. Basina
Samara State Medical University, State Budget Educational Institution of Higher Professional Training of the Ministry of Healthcare and Social Development
Russian Federation
Russian Federation
E. V. Melkadze
Samara State Medical University, State Budget Educational Institution of Higher Professional Training of the Ministry of Healthcare and Social Development
Russian Federation
Russian Federation
References
1. Анкирская А.С. Микроэкология влагалища и профилактика акушерской патологии//Венеролог, 2004. -N 5. -С. 54-59.
2. Гомберг М.А., Соловьев А.М. Лечение уреаплазменной инфекции урогенитального тракта//Лечащий врач. -2004. -№10. -с. 39-42.
3. Доброхотова Ю.Э., Затикян Н.Г. Микроэкология и защитные механизмы влагалища. Акушерство, гинекология и репродукция. 2007; 2: 10-12
4. Доброхотова Ю.Э., Затикян Н.Г. Современные представления о механизмах развития дисбиоза влагалища. Акушерство, гинекология и репродукция. 2008; 1: 7-9
5. Радзинский В.Е. Акушерская агрессия. -М.: 2011. -688 с.
6. Савичева А.М., Соколовский Е.В., Домейка М. с соавт. Методические материалы по диагностике, лечению и профилактике наиболее распространенных инфекций, передаваемых половым путем. Методическое пособие. -СПб.: Издательство Н-Л, 2002.
7. Шендеров Б.А. Медицинская микробная экология и функциональное питание. Том 1: Микрофлора человека и животных и ее функции. -М., Гранть, 1998. -288 c.
8. Balu R.B., Savitz D.A., Ananth C.V. et al. Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth//Obstet. Gynecol. 2003 -Vol. 101. -N 5. -Pt 1. -P. 862-868.
9. Burton J.P., Cadieux P., Reid G. Improved understanding of the bacterial vaginal microbiota of women before and after probiotic instillation//Appl. Environ. Microbiol. -2003. -69. -97-101.
10. Carey J.C., Klebanoff M.A. Is a change in the vaginal flora associated with an increased risk of preterm birth?//Am. J. Obstet. Gynecol. -2005. -Vol. 192. -N 4. -P. 1341-1346.
11. Donders G.G., Vereecken A., Bosmans E., Spitz B. Vaginal cytokines in normal pregnancy//Am. J. Obstet. Gynecol. -2003. -Vol. 189. -N 5. -P. 1433-1438.
12. Draper D.L., Landers D.V., Krohn M.A., Hillier S.L., Wiesenfeld H.C., Heine R.P. Levels of vaginal secretory leukocyte protease inhibitor are decreased in women with lower reproductive tract infections//Am. J. Obstet. Gynecol. -2000. -Vol. 183. -N 5. -P. 12431248.
13. Goplerud C.P., Ohm M.J., Galask R.P. Aerobic and anaerobic flora of the cervix during pregnancy and the puerperium//Am. J. Obstet. Gynecol. -1976. -Vol. 126. -N 7. -P. 858-868.
14. Helmig B.R., Romero R., Espinoza J. et al. Neutrophil elastase and secretory leukocyte protease inhibitor in prelabor rupture of membranes, parturition and intra-amniotic infection//J. Matern. Fetal Neonatal Med. -2002. -Vol. 12. -N 4. -P. 237-246.
15. Helmig R., Uldbjerg N., Ohlsson K. Secretory leukocyte protease inhibitor in the cervical mucus and in the fetal membranes//Eur. J. Obstets. Gynecol. Reprod. Biol. -1995. -Vol. 59. -N 1, 95-101.
16. Jacobsson B., Holst R.M., Wennerholm U.B., Andersson B., Lilja H., Hagberg H. Monocyte chemotactic protein-1 in cervical and amniotic fluid: relationship to microbial invasion of the amniotic cavity, intra-amniotic inflammation, and preterm delivery//Am. J. Obstet. Gynecol. -2003. -Vol. 189. -N 4. -P. 1161-1167.
17. Leitich H., Bodner-Adler B., Brunbauer M. et al. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis//Am. J. Obstet. Gynecol. -2003. -189. -139-147.
18. Puchner T. Infections of the lower genital tract in asymptomatic pregnant women -a prospective study//Z Geburtshilfe Perinatol Perinatol. -1992. -Vol. 196. -N 1. -P. 1-6.
19. Reid G., Devillard E. Probiotics for mother and child//J. Clin. Gastroenterol. -2004. -38 (Suppl.). -94-101.
20. Simhan H.N., Krohn M.A. First-trimester cervical inflammatory milieu and subsequent early preterm birth//Am. J. Obstet. Gynecol. -2009. -Vol. 200. -N 4. -P. 377.e1-377.e4.
21. Thaxton J.E., Sharma S. Interleukin-10: a multifaceted agent of pregnancy//Am J Reprod Immunol. -2010. -Vol. 63. -N 6. -P. 482-491.
Review
For citations:
Spiridonova N.V., Basina E.I., Melkadze E.V. NONSPECIFIC VAGINITIS IN PREGNANTS: IS IT POSSIBLE TO TREAT WITH LACTOBACILLUS MAINTENANCE? Obstetrics, Gynecology and Reproduction. 2012;6(1):6-15. (In Russ.)
Views: 786
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
