From clinical observation to digital prediction: research in contemporary obstetrics, gynecology, and reproduction

The article is devoted to the key research directions presented in the third issue of the journal for 2026. The materials of this issue reflect the transition of contemporary science from traditional clinical observation and pathogenetic analysis to digital prediction, personalized risk assessment, and interdisciplinary interpretation of data. Particular attention is paid to publications addressing the use of artificial intelligence and machine learning for predicting pregnancy complications, as well as the need for critical assessment of source data quality, external validation, and clinical applicability of such models. In addition, the article discusses studies focused on hemostatic disorders, endothelial dysfunction, preeclampsia, reproductive health, gynecologic oncology, assisted reproductive technologies, and cancer-associated thrombosis. In the context of the growing role of digital technologies and generative artificial intelligence in medical science, the importance of methodological rigor, scientific continuity, and authorial responsibility is emphasized. The editorial board is concerned about the increasing number of manuscripts submitted by paper mills.

1. Bayanduryan E.A., Andreeva M.D., Barsukova A.A., Gurova Ya.A. Latent thrombophilic conditions in pregnant and reproductive-age women with an adverse cerebrovascular history and a high risk of acute cerebrovascular events. [Skrytye trombofilicheskie sostoyaniya u beremennyh i zhenshchin reproduktivnogo vozrasta s otyagoshchennym cerebrovaskulyarnym anamnezom i vysokim riskom ONMK]. Obstetrics, Gynecology and Reproduction. 2026;20(3):409–419. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.742.

2. Umakhanova M.M., Mironov A.V., Gabaraeva M.R., Arakelov S.E., Zhukotsky A.V. A new approach to the diagnosis of endothelial dysfunction in pregnant women. [Novyj podhod k diagnostike endotelial'noj disfunkcii u beremennyh]. Obstetrics, Gynecology and Reproduction. 2026;20(3):420–429. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.718.

3. Biryukova М.I., Kutsenko I.I., Kravtsova E.I. Correlation between ERα receptor expression, epitheliocyte nucleus electrokinetic activity, and vaginal microbiocenosis state in vulvovaginal atrophy. [Korrelyaciya mezhdu ekspressiej receptorov ERα, elektrokineticheskoj aktivnost'yu yader epiteliocitov i sostoyaniem vlagalishchnogo mikrobiocenoza pri vul'vovaginal'noj atrofii]. Obstetrics, Gynecology and Reproduction. 2026;20(3):430–442. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.728.

4. Omarova A.O., Taymurova D.Z., Vasilyeva E.V., Aselderova A.Sh., Batchaev A.-Dz.A., Gadzhieva D.A. Efficacy of laparoscopic myomectomy using transient uterine artery occlusion. [Effektivnost' laparoskopicheskoj miomektomii s ispol'zovaniem tranzitornoj okklyuzii matochnyh arterij]. Obstetrics, Gynecology and Reproduction. 2026;20(3):443–451. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.740.

5. Mingareeva K.N., Yaschuk A.G., Tashbulatova F.F. Prevalence of iron and folic acid deficiency, the effectivenessof correction in women of early reproductive age: a prospective cohort study. [Rasprostranennost' deficita zheleza i folievoj kisloty, effektivnost' korrekcii u zhenshchin rannego reproduktivnogo vozrasta: prospektivnoe kogortnoe issledovanie]. Obstetrics, Gynecology and Reproduction. 2026;20(3):452–466. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.772.

6. Tikhonova T.S., Sibirskaya E.V., Smolik L.Yu., Bogacheva A.A., Akhverdian R.A. Reproductive health and metabolic profile features in adolescent girls born to mothers with preeclampsia [Osobennosti reproduktivnogo zdorov'ya i metabolicheskogo profilya devushekpodrostkov, rozhdennyh u materej s preeklampsiej]. Obstetrics, Gynecology and Reproduction. 2026;20(3):468–479. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.751.

7. Vorobеv A.V., Solopova A.G., Bitsadze V.O., Khizroeva J.Kh., Makatsariya N.A., Alieva E.N., Hajibala Z.R., Blinov D.V., Temeshova E.D., Safarova N.G., Makatsariya A.D. Rare forms and atypical locations of cancer-associated thrombosis. [Redkie formy i atipichnye lokalizacii rak-associirovannogo tromboza]. Obstetrics, Gynecology and Reproduction. 2026;20(3):480–490. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.785.

8. Atamasova V.A., Khabibullina S.R., Frumkina Yu.P., Sokolova E.I., Voloshuk A.A., Shishenkova E.G., Borisova A.V., Voronina P.Yu. Application of artificial intelligence models trained on multiparametric datasets for predicting pregnancy complications. [Primenenie modelej iskusstvennogo intellekta na mul'tiparametricheskih naborah dannyh dlya prognozirovaniya oslozhnenij beremennosti]. Obstetrics, Gynecology and Reproduction. 2026;20(3):491–510. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.721.

9. Kapustin R.V., Kiseleva A.V., Alekseenkova E.N., Kopteeva E.V., Kornyushina E.A. Use of low-molecular-weight heparins for the prevention of placenta-associated complications: a systematic review and metaanalysis. [Primenenie nizkomolekulyarnyh geparinov dlya profilaktiki placenta-associirovannyh oslozhnenij: sistematicheskij obzor i metaanaliz]. Obstetrics, Gynecology and Reproduction. 2026;20(3):511–522. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.739.

10. Solopova A.G., Shatilina A.Yu., Martirosyan N.A., Khadanovich M.R., Grigoreva K.N. From deep infiltrative endometriosis to endometriosisassociated cancer: current aspects of differential diagnosis. [Ot glubokogo infil'trativnogo endometrioza k endometrioz-associirovannomu raku: sovremennye aspekty differencial'noj diagnostiki]. Obstetrics, Gynecology and Reproduction. 2026;20(3):523–533. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.763.

11. Karpova A.L., Mostovoi A.V., Baryshnikova I.Yu., Karpov L.N., Magomedova M.A. Heart rate in healthy full-term newborn infants across different historical periods: a systematic review. [Chastota serdechnyh sokrashchenij u zdorovyh donoshennyh novorozhdennyh detej v raznye epohi: sistematicheskij obzor]. Obstetrics, Gynecology and Reproduction. 2026;20(3):534–550. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.734.

12. Oskolkova A.R., Krivulyak A.A., Komelkova A.R., Bitsadze V.O., Khizroeva J.Kh., Solopova A.G., Li O.N., Tretyakova M.V., Blinov D.V., Gris J.-C., Elalamy I., Gerotziafas G., Makatsariya A.D. Recurrent severe preeclampsia and the risk of late cardiovascular complications. [Povtornye tyazhelye preeklampsii i risk otdalennyh serdechno-sosudistyh oslozhnenij]. Obstetrics, Gynecology and Reproduction. 2026;20(3):551–559. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.764.

13. Sarkisyan N.M., Kulenko O.N., Vasischev D.S., Savenko A.V., Babaeva S.K., Khubieva M.R., Oganova A.S., Mirzebasova A.M., Tsakaeva E.A., Samurganova M.D., Gusarova S.S., Efanov V.O. Molecular and immunological predictors of outcomes in assisted reproductive technology programs. [Molekulyarnye i immunnye prediktory effektivnosti programm vspomogatel'nyh reproduktivnyh tekhnologij]. Obstetrics, Gynecology and Reproduction. 2026;20(3):560–574. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.731.

14. Solopova A.G., Bitsadze V.O., Lazarchuk A.V., Makatsariya N.A., Tishchenko M.A., Utkin D.O., Blinov D.V. Vulvar premalignant lesions and cancer: what's new in diagnosis, treatment, and rehabilitation? [Predrak i rak vul'vy: chto novogo v diagnostike, lechenii i reabilitacii?]. Obstetrics, Gynecology and Reproduction. 2026;20(3):575–590. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.776.

15. Vorobev А.V., Chekalina A.O., Dolinina A.D., Stepanova O.O., Makatsariya A.D. Cancer and thrombosis: from a 19th-century clinical phenomenon to the modern concept of tumor-associatedcoagulopathy. [Rak i tromboz: ot klinicheskogo fenomena XIX veka k sovremennoj koncepcii opuhol'-associirovannoj koagulopatii].Obstetrics, Gynecology and Reproduction. 2026;20(3):591–599. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.787.

16. RETRACTION NOTE: The role of sphingolipid metabolism in female reproductive health disorders. [Rol' sfingolipidnogo metabolizma v razvitii narushenij reproduktivnogo zdorov'ya zhenshchin]. Obstetrics, Gynecology and Reproduction. 2026;20(1):229–234. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.732.