Stratification, personalization, prevention: modern vectors of development in obstetrics and gynecology

This editorial summarizes the materials from the first issue of 2026, united by the idea of moving toward predictive and personalized medicine in obstetrics and gynecology. Original research presents digital models for risk stratification of preterm birth and preeclampsia, neural network algorithms for selecting therapy for ovulation disorders, immunological and coagulation markers of placental complications, as well as data on long-term cardiometabolic risks after preeclampsia and factors preserving ovarian reserve. Review publications highlight current understanding of thrombosis pathogenesis in paroxysmal nocturnal hemoglobinuria, the role of natriuretic peptide in obstetrics and neonatology, immunocoagulation mechanisms of amniotic fluid embolism, the molecular basis of HPV-associated neoplasia, and fertility restoration strategies in women of late reproductive age. A clinical case of antenatal diagnosis of placenta accreta using modern ultrasound criteria is presented. The issue also includes retraction note due to identified unfair plagiarism, underscoring the editorial board's commitment to publication ethics. Taken together, the materials in this issue reflect contemporary developments in the specialty – risk stratification, personalized therapy, and the expansion of preventive care in obstetrics and gynecology.

1. Boldina Yu.S., Ivshin A.A., Svetova K.S. From data to prediction: development and clinical validation of a preterm birth risk assessment tool based on machine learning technologies. [Ot dannyh k prognozu: razrabotka i klinicheskaya aprobaciya instrumenta ocenki riska prezhdevremennyh rodov na osnove tekhnologij mashinnogo obucheniya]. Obstetrics, Gynecology and Reproduction. 2026;20(1):15–33. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.701.

2. Dikke G.B., Mudrov V.A., Efendieva R.M., Abusueva Z.A. Treatment selection and anovulation predictors in patients with obesity and oligo-/ amenorrhea assisted by neural network technology. [Vybor lecheniya dlya vosstanovleniya ovulyacii u pacientok s ozhireniem i oligo-/amenoreejs pomoshch'yu nejrosetevoj tekhnologii]. Obstetrics, Gynecology and Reproduction. 2026;20(1):34–50. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.688.

3. Eremeeva D.R., Zainulina M.S. Predicting chronic placental insufficiency in patients with a complicated obstetric history at pregnancy planning stage. [Prognozirovanie razvitiya hronicheskoj placentarnoj nedostatochnosti u pacientok s otyagoshchennym akusherskim anamnezom na etape planirovaniya beremennosti]. Obstetrics, Gynecology and Reproduction. 2026;20(1):51–66. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.670.

4. Antonova A.S., Tretyakova M.V., Khizroeva J.Kh., Bitsadze V.O., Kuneshko N.F., Morkos S., Kalashnikova I.S., Rouzy N., Gerotziafas G., Elalamy I., Makatsariya A.D. The role of complement components (C1q, C3a, MAC) activation in earlyand late-onset preeclampsia and fetal growth restriction. [Rol' aktivacii komponentov sistemy komplementa (C1q, C3a, MAC) pri rannej i pozdnej preeklampsii i sindrome zaderzhki rosta ploda]. Obstetrics, Gynecology and Reproduction. 2026;20(1):67–81. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.703.

5. Tikhonova T.S., Sibirskaya E.V., Bogacheva A.A., Smolik L.Yu. Somatic health of women with a history of preeclampsia who delivered female infants. [Somaticheskoe zdorov'e zhenshchin s preeklampsiej v anamneze, rodivshih devochek]. Obstetrics, Gynecology and Reproduction. 2026;20(1):82–90. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.713.

6. Kalimatova D.M., Dobrokhotova Yu.E., Kazieva M.D., Ilyina I.Yu., Ibragimova J.M. Features of reproductive potential in patients with extensive endometriosis forms. [Osobennosti reproduktivnogo potenciala u pacientok s rasprostranennymi formami endometrioza]. Obstetrics, Gynecology and Reproduction. 2026;20(1):91–101. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.676.

7. Lukmanova L.Kh., Muslimova S.Yu., Sakhautdinova I.V. Lichen sclerosus clinic in girls of various age groups. [Klinika skleroziruyushchego lihena u devochek razlichnyh vozrastnyh grupp]. Obstetrics, Gynecology and Reproduction. 2026;20(1):102–110. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.574.

8. Ivshin A.A., Malyshev N.A. Preeclampsia early risk stratification based on a multiparametric machine learning model and routinely collected clinical data. [Rannyaya stratifikaciya riska preeklampsii na osnove mul'tiparametricheskoj modeli mashinnogo obucheniya i rutinnyh klinicheskih dannyh]. Obstetrics, Gynecology and Reproduction. 2026;20(1):111–129. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.706.

9. Yagubova F.E., Bitsadze V.O., Samburova N.V., Khizroeva J.Kh., Blinov D.V., Gris J.-C., Elalamy I., Gerotziafas G., Makatsariya A.D. The importance of hemostasis control for anticoagulant therapy during post-IVF pregnancy in patients with burdened obstetric history. [Znachenie kontrolya za gemostazom pri provedenii antikoagulyantnoj terapii pri beremennosti posle EKO u pacientok s otyagoshchennym akusherskim anamnezom]. Obstetrics, Gynecology and Reproduction. 2026;20(1):130–145. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.707.

10. Khisamieva A.R., Oskolkova A.R., Bitsadze V.O., Khizroeva J.Kh., Tretyakova M.V., Makatsariya N.A., Gashimova N.R., Grigoreva K.N., Blinov D.V., Gris J.-C., Elalamy I., Gerotziafas G., Makatsariya A.D. Paroxysmal nocturnal hemoglobinuria and thrombosis. [Paroksizmal'naya nochnaya gemoglobinuriya i trombozy]. Obstetrics, Gynecology and Reproduction. 2026;20(1):146–157. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.726.

11. Aganezova N.V., Aganezov S.S. The place of the three-phase combined oral ethinyl estradioland desogestrelbased contraceptive in modern obstetrician-gynecologist practice. [Mesto trekhfaznogo kombinirovannogo oral'nogo kontraceptiva s etinilestradiolom i dezogestrelom v sovremennoj praktike akushera-ginekologa]. Obstetrics, Gynecology and Reproduction. 2026;20(1):158–167. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.719.

12. Ignatko I.V., Seurko K.I., Timokhina E.V., Sarakhova D.Kh., Titov V.A., Seurko K.I., Akhmedova A.E. Clinical significance of brain natriuretic peptide during pregnancy and early neonatal adaptation of newborns. [Klinicheskoe znachenie mozgovogo natrijureticheskogo peptida pri beremennosti i rannej neonatal'noj adaptacii novorozhdennyh]. Obstetrics, Gynecology and Reproduction. 2026;20(1):169–176. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.627.

13. Oskolkova A.R., Khisamieva A.R., Bitsadze V.O., Khizroeva J.Kh., Tretyakova M.V., Makatsariya N.A., Gashimova N.R., Grigoreva K.N., Panfilova O.Yu., Gris J.-C., Elalamy I., Gerotziafas G., Makatsariya A.D. Amniotic fluid embolism as an immunocoagulatory catastrophic anaphylactoid syndrome. [Emboliya okoloplodnymi vodami kak immunokoagulyacionnyj katastroficheskij anafilaktoidnyj sindrom]. Obstetrics, Gynecology and Reproduction. 2026;20(1):177–191. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.725.

14. Shchukin V.Yu., Gerfanova E.V., Babaeva N.A., Aleshikova O.I., Mukhsinzoda N.A., Kiselev V.I., Ashrafyan L.A. Once again about HPV and cervical neoplasia: biology and pathogenesis. [Eshche raz o VPCh i cervikal'noj neoplazii: biologiya i patogenez]. Obstetrics, Gynecology and Reproduction. 2026;20(1):192–203. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.642.

15. Shukurov F.I., Akhmedzhanova Kh.Z., Madolimova N.X. Current approaches to restore fertility in women of advanced reproductive age with low ovarian reserve: a literature review. [Sovremennye podhody k vosstanovleniyu fertil'nosti u zhenshchin pozdnego reproduktivnogo vozrasta s nizkim ovarial'nym rezervom: obzor literatury]. Obstetrics, Gynecology and Reproduction. 2026;20(1):204–219. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.695.

16. Eliava E., Verulava T. Role of modern ultrasonography in antenatal detection of placenta increta: a case report. [Rol' sovremennoj ul'trasonografii v antenatal'noj diagnostike vrastaniya placenty: klinicheskij sluchaj]. Obstetrics, Gynecology and Reproduction. 2026;20(1):220–228. (In English). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.677.

17. Policheva A.A., Oganesyan E.A., Yarushkina I.S., Martynenko A.S., Kormukhina E.E., Taimova Ch.O., Mustafina A.R., Kim V.V., Valitova A.A., Suleimanov N.R., Gaibaryan K.A., Radzhabov M.E., Baimukhambetova A.E., Razumova A.E. The role of sphingolipid metabolism in female reproductive health disorders. [Rol' sfingolipidnogo metabolizma v razvitii narushenij reproduktivnogo zdorov'ya zhenshchin]. Obstetrics, Gynecology and Reproduction. 2025;[published online]. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.691.

18. RETRACTION NOTE: The role of sphingolipid metabolism in female reproductive health disorders. [UVEDOMLENIE OB OTZYVE STAT'I: Rol' sfingolipidnogo metabolizma v razvitii narushenij reproduktivnogo zdorov'ya zhenshchin]. Obstetrics, Gynecology and Reproduction. 2026;20(1):229–234. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2026.732.