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FETOPLACENTAL ANGIOGENESIS IN PREGNANT WOMEN WITH PLACENTAL INSUFFICIENCY

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Abstract

The article presents the results of the studing of fetoplacental angiogenesis, as the reason of placenta malfunction and featus progress.
The objective: the examination included 116 pregnant famale patients with placental insufficiency and growth retardation syndrome and 52 pregnant famale patients with physiological pregnancy. Results: it was determined that proangiogenic vessel factor – placental growth factor (P1GF) and angiogenic vessel factors are the soluble fms-like tyrozinkinaze (sFlt-1) and soluble endogline (sEng). There was determined angiogenic coefficient – Ka, calculated in formule sFlt-1/PlGF×10.
Conclusion: it was revealed that placental insufficiency characterized falure balance of vessel growth factors, enlarged levels of angiogenic vessel factors and low levels of proangiogenic factor. For the development of placental insufficiency and enlarged stage of growth retardation syndrome the increasion of angiogenic coefficient Ka is typical.

About the Authors

O. V. Makarov
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation (Moscow)
Russian Federation


E. V. Volkova
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation (Moscow)
Russian Federation


E. Yu. Lysyuk
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation (Moscow)
Russian Federation


Yu. V. Kopylova
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation (Moscow)
Russian Federation


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For citation:


Makarov O.V., Volkova E.V., Lysyuk E.Yu., Kopylova Yu.V. FETOPLACENTAL ANGIOGENESIS IN PREGNANT WOMEN WITH PLACENTAL INSUFFICIENCY. Obstetrics, Gynecology and Reproduction. 2013;7(3):13-19. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)