PECULIARITIES OF STIMULATION OF OVULATION IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME OF DIERENT AGE
Abstract
The aim of this work was to estimate the effectiveness of stimulation of ovulation in women with polycystic ovarian syndrome (PCOS) in different age groups depending on existence of previous pregnancies.
Methods: The design was retrospective, observational, unicentral study. Investigation includes 62 women from 21 till 40 years old with PCOS and previous ineffective medicinal treatment. Ovarian stimulation with the use of antiestrogens (clomiphene citrate) and recombinant folliclestimulating hormone (follitropin) was conducted.
The final pointwas visualization of the ovum by ultrasound investigation on the day 21 after ovulation. As the result of ovarian stimulation ovulation occurred in every case. In the group of patients before 30 years old pregnancy rate was 41,94%, in the group 30-35 years old – 38,1%, in the group older than 35 years – 20%. In the groups 30-35 years old and older than 35 years old the int errelation between the effectiveness of stimulation of ovulation and existence of previous pregnancies was observed. Thus, in women with pregnancies in anamnesis the final points were achieved in 75 % (group 30-35 years old) and 25% (group older than 35 years). Without previous pregnancies stimulation of ovulation was not effective (0%) in the group of patients older than 35 years old and less effective (23,08%) in the group of patients30-35 years old. In the women younger than 30 years the correlation between effectiveness of stimulation of
ovulation and existence of previous pregnancies was not observed.
Conclusion: In the group of patients older than 30 years old stimulation of ovulation have higher effectiveness among
women with pregnancies in anamnesis.
Methods: The design was retrospective, observational, unicentral study. Investigation includes 62 women from 21 till 40 years old with PCOS and previous ineffective medicinal treatment. Ovarian stimulation with the use of antiestrogens (clomiphene citrate) and recombinant folliclestimulating hormone (follitropin) was conducted.
The final pointwas visualization of the ovum by ultrasound investigation on the day 21 after ovulation. As the result of ovarian stimulation ovulation occurred in every case. In the group of patients before 30 years old pregnancy rate was 41,94%, in the group 30-35 years old – 38,1%, in the group older than 35 years – 20%. In the groups 30-35 years old and older than 35 years old the int errelation between the effectiveness of stimulation of ovulation and existence of previous pregnancies was observed. Thus, in women with pregnancies in anamnesis the final points were achieved in 75 % (group 30-35 years old) and 25% (group older than 35 years). Without previous pregnancies stimulation of ovulation was not effective (0%) in the group of patients older than 35 years old and less effective (23,08%) in the group of patients30-35 years old. In the women younger than 30 years the correlation between effectiveness of stimulation of
ovulation and existence of previous pregnancies was not observed.
Conclusion: In the group of patients older than 30 years old stimulation of ovulation have higher effectiveness among
women with pregnancies in anamnesis.
About the Authors
M. P. Mironova
«Women`s Health» clinic, Ufa
Russian Federation
Russian Federation
E. A. Fazlieva
«Women`s Health» clinic, Ufa
Russian Federation
Russian Federation
References
1. Дедова И.И., Мельниченко Г.А. Синдром поликистозных яичников. М. 2007; 368 с.
2. Генри М. Коненберг, ШломоМелмед, Кеннет С. Полонски, П. Рид Ларсен. Репродуктивная эндокринология. Рид Элствер. 2011; 116 с.
3. Геворкян М.А., Блинов Д.В., Смирнова С.О. Комбинированные оральные контрацептивы в лечении пациенток с синдромом поликистозных яичников. Акушерство, гинекология и репродукция. 2012; 1: 39-49
4. Гуриев Т.Д. Синдром поликистозных яичников. Акушерство, гинекология и репродукция. 2010; 2: 10-15.
5. Мишиева Н.Г., Назаренко Т.А., Дуринян Э.Р., Абубакиров А.Н. Оптимизация лечения бесплодия у больных с синдромом поликистозных яичников. Врач. 2008; 5: 71-75.
6. Назаренко Т.А., Чечурова Т.Н., Дуринян Э.Р. и др. Обоснование дифференцированного подхода к индукции овуляции при лечении бесплодия у больных с поликистозными яичниками. Проблемы репродукции. 2002; 3: 52-56.
7. Сидельникова В.М. Эндокринология беременности. М. 2007; 351 с.
8. Томсон Р.Л., Бринкворф Дж.Д., Нокес М., Клифтон П.М. Влияние диеты и физических нагрузок на маркеры функции эндотелия у пациенток с избыточным весом или ожирением и СПКЯ. Репродукция человека. 2012; 5: 44-51.
9. Хомбург Р., Хендрикс М.Л., Кенинг Т.Е., Андерсон Р.А. Кломифена цитрат или низкие дозы ФСГ в качестве средств первой линии для лечения бесплодия у женщин с ановуляцией, обусловленной синдромом поликистозных яичников: проспективное рандомизированное многонациональное исследование. Репродукция человека. 2012; 4: 48-53.
10. Уварова Е.В. Возможности применения комбинированных оральных контрацептивов в пролонгированном режиме при лечении СПКЯ. Проблемы репродукции. 2006; 4: 73-75.
11. Vrbikova J., Hill M., Starka L., Vondra K. Prediction of the effect of metformin treatment in patients with polycystic ovary syndrome.Gynecol. Obstet. Invest. 2002; 53: 100-104.
Review
For citations:
Mironova M.P., Fazlieva E.A. PECULIARITIES OF STIMULATION OF OVULATION IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME OF DIERENT AGE. Obstetrics, Gynecology and Reproduction. 2013;7(3):9-12. (In Russ.)
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