Preview

Obstetrics, Gynecology and Reproduction

Advanced search

PATHOGENESIS AND PATHOGENETICALLY SUBSTANTIATED THERAPY OF CHRONIC ENDOMETRITIS (сlinical lecture)

Full Text:

Abstract

Chronic endometritis (CE) - a common disease with no unified concept of pathogenesis, characterized by undulating and ever-progressive pathological process. Important pathogenic factors contributing to the development of CE, is immune deficiency and violation of endometrium angioarchitectonics. Currently has been widely discussed question of the pro- and antioxidant systems imbalance role in the pathogenesis of HE. From these positions, it is obvious that the stimulation of natural antioxidant systems, introduction of exogenous antioxidants - one of the essential moments in the treatment of CE. Actovegin is a one of the modern drugs which is best meets the requirements of CE pathogenic-based therapy and has an impact on the above links of pathogenesis. Actovegin contains components with high biological activity: amino acids, oligopeptides, nucleosides, oligosaccharides and glycolipides, enzymes, electrolytes, and a number of important macro- and micronutrients. Exacerbation of already existing chronic inflammation often occurs after an abortion and therapeutic surgical procedures. Therefore, an important measure to prevent the exacerbation of chronic endometritis, an essential part of the treatment of post-abortion or postpartum CE, treatment and diagnostic curettage is the rehabilitation of structural and functional state of the endometrium with the use of Actovegin.

About the Authors

I. S. Sidorova
Department of Obstetrics and Gynecology, First MGMU named after I.M. Sechenov
Russian Federation


I. O. Makarov
Department of Obstetrics and Gynecology, First MGMU named after I.M. Sechenov
Russian Federation


A. L. Unanyan
Department of Obstetrics and Gynecology, First MGMU named after I.M. Sechenov
Russian Federation


R. S. Vlasov
Department of Obstetrics and Gynecology, First MGMU named after I.M. Sechenov
Russian Federation


D. V. Karpov
Department of Obstetrics and Gynecology, First MGMU named after I.M. Sechenov
Russian Federation


References

1. Краснопольский В. И., Серова О. Ф., Туманова В. А., и др. Влияние инфекций на репродуктивную систему женщин. -Российский вестник акушера-гинеколога, -№5, -2004.

2. Кузнецова А. В. Хронический эндометрит. Арх. патол. 2000; 3 (62): 48-52.

3. Подзолкова Н. М., Бархина Т. Г., Осадчев В. Б. и др.//Роль панорамной и микрогистероскопии в диагностике хронического эндометрита.-Россйский вестник акушера-гинеколога, -№6, -2004.

4. Шуршалина А.В., Ежова Л.С., Силантьева Е.С. Патогенетические подходы к терапии хронического эндометрита//Акушерство и гинекология. -2004. -№6. -С. 54-56.

5. Шуршалина А.В., Дубницкая Л.В. Иммуномодулирующая терапия в программе реабилитации пациенток с хроническим эндометритом//Российский Вестник акушера-гинеколога. -2006. -№ 1. -С. 36-38.

6. Buckley C.H., Fox H. Biopsy pathology of the endometrium. Arnold., 2002.

7. Eckert L.O., Hawes SE. Endometritis: The clinical-pathologic syndrome. Am J Obstet Gynecol 2002; 186 (4): 690-5.

8. Eisert W.G. Dipiridamole//Platelets/Ed.by Michelson A.D. Cambridge (USA),2002. P. 215.

9. Glasser S.R., Aplin JD. The endometrium. Taylor and Francis., 2002.

10. Sharkey A.M., Smith S.K. The endometrium as a cause of implantation failure. Best Practice & Research Clinical Obstetrics Gynecology. 2003; 17 (2):289-307.


For citation:


Sidorova I.S., Makarov I.O., Unanyan A.L., Vlasov R.S., Karpov D.V. PATHOGENESIS AND PATHOGENETICALLY SUBSTANTIATED THERAPY OF CHRONIC ENDOMETRITIS (сlinical lecture). Obstetrics, Gynecology and Reproduction. 2010;4(3):21-24. (In Russ.)

Views: 86


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)