Surface-enhanced Raman spectroscopy as a method for diagnosing benign ovarian formations in pregnant women
https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.516
Abstract
Aim: to study the spectral characteristics of blood plasma in pregnant women with benign ovarian formations (OF).
Materials and Methods. A retrospective study conducted between 2021 and 2023 included 100 pregnant women aged 18 to 45 years. Two groups were identified: group 1 (main group) included 50 pregnant women with OF, group 2 (control group) included 50 pregnant women with normal pregnancy. Using the method of surface-enhanced Raman spectroscopy (SERS), we determined and assessed the spectral features typical to OF, which are necessary for differential diagnosis of this pregnancy-related pathology.
Results. Prominent inter-group differences in spectral intensities were revealed: OF was associated with significantly increased intensity of spectral peaks at 491 nm, 596 nm, 632 nm, 808 nm, 886 nm, 1132 nm and decreased intensity at the peaks of 725 nm and 1440 nm observed compared to control group. After OF removal, spectral pattern restored to near complete compliance with the spectral pattern observed in control group of pregnant women.
Conclusion. The isolated and analyzed spectral features demonstrated an opportunity of using SERS in diagnosing OF in pregnant women.
About the Authors
D. A. Fatkullina
Bashkir State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Dinara A. Fatkullina, MD.
3 Lenin Str., Ufa 450008
I. I. Musin
Bashkir State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Ilnur I. Musin, MD, Dr Sci Med.
3 Lenin Str., Ufa 450008
A. G. Yashchuk
Bashkir State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Alfiya G. Yashchuk, MD, Dr Sci Med, Prof.
3 Lenin Str., Ufa 450008
E. M. Gareev
Bashkir State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Eugeny M. Gareev, MD, PhD in Biology.
3 Lenin Str., Ufa 450008
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What is already known about this subject?
► The method, based on assessing scattered light and its interaction with matter, creates a special “biochemical imprint”.
► Surface-enhanced Raman spectroscopy (SERS) is used not only in medicine, but also in other fields, such as biology, pharmacy, forensics, etc.
What are the new findings?
► A non-invasive method for diagnosing benign ovarian formations (OF) in pregnant women is presented.
How might it impact on clinical practice in the foreseeable future?
► SERS may be considered as a potential research method in pregnant women with ovarian neoplasms.
► SERS will reduce the frequency of OF over-diagnosing, and will also help to make right decision on OF removal during pregnancy.
Review
For citations:
Fatkullina D.A., Musin I.I., Yashchuk A.G., Gareev E.M. Surface-enhanced Raman spectroscopy as a method for diagnosing benign ovarian formations in pregnant women. Obstetrics, Gynecology and Reproduction. 2025;19(1):59-67. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.516
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