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Homocysteine, cancer and oncothrombosis

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.431

Abstract

Introduction. Hyperhomocysteinemia (HHC) is one of the arms in the pathogenesis of thrombotic complications in female cancer patients.

Aim: to assess an HHC-related impact to developing thrombotic complications in patients with malignant neoplasms of the female genital organs and breast cancer.

Materials and Methods. There were retrospectively evaluated the data collected from 236 patients: with ovarian tumors (n = 63), cervical cancer (n = 51), breast tumors (n = 64), malignant neoplasms of the uterine body (n = 58). The control group consisted of 50 women without malignant neoplasms. The analysis of homocysteine (HC) concentration, the frequency of polymorphisms of the genes encoding folate cycle enzymes MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G as well as the rate of thrombotic complications was carried out. A risk of blood HC level-related thrombotic complications was assessed.

Results. Plasma HC concentration comprised ≥ 22 μmol/l in 30.5 % of patients. Thrombotic complications within one year after discharge from the hospital were developed in 15.3 % cases. The risk of thrombotic complications turned out to be higher in patients with elevated plasma HC level (≥ 22 μmol/l) (odds ratio = 2.99; 95 % confidence interval = 1.11–8.08). No significantly increased prevalence of polymorphisms in the genes encoding folate cycle enzymes among female cancer patients was detected.

Conclusion. Monitoring HC level in female cancer patients contributes separately to predict a likelihood of thrombotic complications. Prescribing drugs that reduce HC level (folic acid) and monitoring its concentration in female cancer patients during therapy, including chemotherapy, can potentially lower an incidence of thrombotic complications.

About the Authors

V. O. Bitsadze
Sechenov University
Russian Federation

Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 6506003478.
Researcher ID: F-84092017



E. V. Slukhanchuk
Sechenov University
Russian Federation

Ekaterina V. Slukhanchuk – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Healt

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



A. G. Solopova
Sechenov University
Russian Federation

Antonina G. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

Scopus Author ID: 6505479504.
Researcher ID: Q-1385-2015

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



J. Kh. Khizroeva
Sechenov University
Russian Federation

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 57194547147.
Researcher ID: F-8384-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



D. V. Shcherbakov
Sechenov University
Russian Federation

Denis V. Shcherbakov – MD, PhD, Associate Professor, Department of General Hygiene, Erisman Institute of Public Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



F. E. Yakubova
Sechenov University
Russian Federation

Fidan E. Yakubova – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



J.-C. Gris
Sechenov University; University of Montpellier
Russian Federation

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor of Haematology, Head of the Laboratory of Haematology, Faculty of Biological and Pharmaceutical Sciences, Montpellier University and University Hospital of Nîmes, France; Foreign Member of RAS

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991, Russia; 
163 Rue Auguste Broussonnet, Montpellier 34090, France



I. Elalamy
Sechenov University; Medicine Sorbonne University; Hospital Tenon
Russian Federation

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University, Paris, France; Director of Hematology, Department of Thrombosis Center, Hospital Tenon

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991, Russia; 
12 Rue de l’École de Médecine, Paris 75006, France; 
4 Rue de la Chine, Paris 75020, France



N. D. Degtyareva
Sechenov University
Russian Federation

Natalia D. Degtyareva – 5th year Student, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



A. V. Lazarchuk
Sechenov University
Russian Federation

Arina V. Lazarchuk – 5th year Student, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



M. A. Gileva
Sechenov University
Russian Federation

Maria A. Gileva – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



N. V. Samburova
Sechenov University
Russian Federation

Natalia V. Samburova – MD, PhD, Associate Professor, Department of Pathophysiology, Institute of Biodesign and Modeling of Complex Systems

Scopus Author ID: 57208129705

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



Z. D. Aslanova
Sechenov University
Russian Federation

Zamilya D. Aslanova – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



D. V. Blinov
Sechenov University; Institute for Preventive and Social Medicine; Moscow Haass Medical – Social Institute
Russian Federation

Dmitry V. Blinov – MD, PhD, MBA, Assistant, Department of Sports Medicine and Medical Rehabilitation, Sklifosovsky Institute of Clinical Medicine, Sechenov University; Head of Medical and Scientific Affairs, Institute for Preventive and Social Medicine; Associate Professor, Department of Sports, Physical and Rehabilitation Medicine, Moscow Haass Medical – Social Institute

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991;
4–10 Sadovaya-Triumfalnaya Str., Moscow 127006; 
2/44 Salyama Adilya Str., Moscow 123423



A. S. Shkoda
Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department
Russian Federation

Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician

2/44 Salyama Adilya Str., Moscow 123423



A. D. Makatsariya
Sechenov University
Russian Federation

Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Vice-President of the Russian Society of Obstetricians and Gynecologists (RSOG); Honorary Doctor of the Russian Federation; Emeritus Professor of the University of Vienna

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991



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Review

For citations:


Bitsadze V.O., Slukhanchuk E.V., Solopova A.G., Khizroeva J.Kh., Shcherbakov D.V., Yakubova F.E., Gris J., Elalamy I., Degtyareva N.D., Lazarchuk A.V., Gileva M.A., Samburova N.V., Aslanova Z.D., Blinov D.V., Shkoda A.S., Makatsariya A.D. Homocysteine, cancer and oncothrombosis. Obstetrics, Gynecology and Reproduction. 2023;17(4):390-401. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.431

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)