Homocysteine, cancer and oncothrombosis
https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.431
Abstract
Introduction. Hyperhomocysteinemia (HHC) is one of the arms in the pathogenesis of thrombotic complications in female cancer patients.
Aim: to assess an HHC-related impact to developing thrombotic complications in patients with malignant neoplasms of the female genital organs and breast cancer.
Materials and Methods. There were retrospectively evaluated the data collected from 236 patients: with ovarian tumors (n = 63), cervical cancer (n = 51), breast tumors (n = 64), malignant neoplasms of the uterine body (n = 58). The control group consisted of 50 women without malignant neoplasms. The analysis of homocysteine (HC) concentration, the frequency of polymorphisms of the genes encoding folate cycle enzymes MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G as well as the rate of thrombotic complications was carried out. A risk of blood HC level-related thrombotic complications was assessed.
Results. Plasma HC concentration comprised ≥ 22 μmol/l in 30.5 % of patients. Thrombotic complications within one year after discharge from the hospital were developed in 15.3 % cases. The risk of thrombotic complications turned out to be higher in patients with elevated plasma HC level (≥ 22 μmol/l) (odds ratio = 2.99; 95 % confidence interval = 1.11–8.08). No significantly increased prevalence of polymorphisms in the genes encoding folate cycle enzymes among female cancer patients was detected.
Conclusion. Monitoring HC level in female cancer patients contributes separately to predict a likelihood of thrombotic complications. Prescribing drugs that reduce HC level (folic acid) and monitoring its concentration in female cancer patients during therapy, including chemotherapy, can potentially lower an incidence of thrombotic complications.
Keywords
About the Authors
V. O. BitsadzeRussian Federation
Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health
Scopus Author ID: 6506003478.
Researcher ID: F-84092017
E. V. Slukhanchuk
Russian Federation
Ekaterina V. Slukhanchuk – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Healt
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
A. G. Solopova
Russian Federation
Antonina G. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health
Scopus Author ID: 6505479504.
Researcher ID: Q-1385-2015
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
J. Kh. Khizroeva
Russian Federation
Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health
Scopus Author ID: 57194547147.
Researcher ID: F-8384-2017
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
D. V. Shcherbakov
Russian Federation
Denis V. Shcherbakov – MD, PhD, Associate Professor, Department of General Hygiene, Erisman Institute of Public Health
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
F. E. Yakubova
Russian Federation
Fidan E. Yakubova – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
J.-C. Gris
Russian Federation
Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor of Haematology, Head of the Laboratory of Haematology, Faculty of Biological and Pharmaceutical Sciences, Montpellier University and University Hospital of Nîmes, France; Foreign Member of RAS
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991, Russia;
163 Rue Auguste Broussonnet, Montpellier 34090, France
I. Elalamy
Russian Federation
Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University, Paris, France; Director of Hematology, Department of Thrombosis Center, Hospital Tenon
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991, Russia;
12 Rue de l’École de Médecine, Paris 75006, France;
4 Rue de la Chine, Paris 75020, France
N. D. Degtyareva
Russian Federation
Natalia D. Degtyareva – 5th year Student, Filatov Clinical Institute of Children’s Health
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
A. V. Lazarchuk
Russian Federation
Arina V. Lazarchuk – 5th year Student, Filatov Clinical Institute of Children’s Health
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
M. A. Gileva
Russian Federation
Maria A. Gileva – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
N. V. Samburova
Russian Federation
Natalia V. Samburova – MD, PhD, Associate Professor, Department of Pathophysiology, Institute of Biodesign and Modeling of Complex Systems
Scopus Author ID: 57208129705
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
Z. D. Aslanova
Russian Federation
Zamilya D. Aslanova – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
D. V. Blinov
Russian Federation
Dmitry V. Blinov – MD, PhD, MBA, Assistant, Department of Sports Medicine and Medical Rehabilitation, Sklifosovsky Institute of Clinical Medicine, Sechenov University; Head of Medical and Scientific Affairs, Institute for Preventive and Social Medicine; Associate Professor, Department of Sports, Physical and Rehabilitation Medicine, Moscow Haass Medical – Social Institute
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991;
4–10 Sadovaya-Triumfalnaya Str., Moscow 127006;
2/44 Salyama Adilya Str., Moscow 123423
A. S. Shkoda
Russian Federation
Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician
2/44 Salyama Adilya Str., Moscow 123423
A. D. Makatsariya
Russian Federation
Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Vice-President of the Russian Society of Obstetricians and Gynecologists (RSOG); Honorary Doctor of the Russian Federation; Emeritus Professor of the University of Vienna
2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991
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Review
For citations:
Bitsadze V.O., Slukhanchuk E.V., Solopova A.G., Khizroeva J.Kh., Shcherbakov D.V., Yakubova F.E., Gris J., Elalamy I., Degtyareva N.D., Lazarchuk A.V., Gileva M.A., Samburova N.V., Aslanova Z.D., Blinov D.V., Shkoda A.S., Makatsariya A.D. Homocysteine, cancer and oncothrombosis. Obstetrics, Gynecology and Reproduction. 2023;17(4):390-401. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.431

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