Preview

Obstetrics, Gynecology and Reproduction

Advanced search

ANTITHROMBOTIC PROPHYLAXIS RECURRENT PREECLAMPSIA IN PATIENTS WITH THROMBOPHILIA

https://doi.org/10.17749/2070-4968.2015.9.3.028-034

Full Text:

Abstract

Objective. To evaluate the efficiency of antithrombotic therapy to prevent repeated preeclampsia in patients with thrombophilia. Subject and methods. A prospective clinical study was conducted 66 patients with thrombophilia (genetic, acquired or concomitant) and with history of preeclampsia: 35 patients addressed and were followed since fertile cycle (subgroup Ia) and 31 patients addressed during pregnancy and were followed since 6-13 weeks of gestation - IIa subgroup. Control group - 50 patients without both obstetrics and gynecology and thrombotic complications in history. Therapy included LMWG (Enoxaparinum natrium), B vitamins, antioxidants and micronized progesterone. Results. The all period of pregnancy, obstetric and perinatal outcomes were better in patients receiving therapy since fertile cycle compared with group of patients whose therapy was initiated during pregnancy. Conclusion. To prevent re-PE at a subsequent pregnancy, the therapy should be start since fertile cycle, continuing during pregnancy, childbirth and the postpartum period. Therapy should include LMWH, B vitamins, antioxidants and micronized progesterone.

About the Authors

E. V. Zhuravleva
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
MD, PhD, research associate of the Ob/Gyn Department


V. O. Bitsadze
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
MD., Professor, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive


A. D. Makatsariya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
MD, corresponding member of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medical and Preventive


For citation:


Zhuravleva E.V., Bitsadze V.O., Makatsariya A.D. ANTITHROMBOTIC PROPHYLAXIS RECURRENT PREECLAMPSIA IN PATIENTS WITH THROMBOPHILIA. Obstetrics, Gynecology and Reproduction. 2015;9(3):28-34. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.3.028-034

Views: 95


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)