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THROMBOPHILIA AND FAILURES OF EXTRACORPORAL FERTILIZATION

https://doi.org/10.17749/2070-4968.2015.9.3.017-021

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Abstract

Objective. It was study the frequency and a range of the genetic and acquired thrombophilia at patients with failures of in-vitro fertilization (IVF). Materials and methods. 115 women who had from 1 to 9 unsuccessful attempts of IVF were examined. Genetic thrombotic mutations, circulation AFA and level of a gomotsistein (an immunofermental method) were defined. Results. High frequency of the genetic forms of a thrombophilia influencing the level of an endogenous fibrinoliz (polymorphisms of plasminogen activator inhibitor-1 (PAI-1) - 66.9%, the tissue-type plasminogen activator (TPA) - 60.9%, fibrinogen - 47.8%), in combination with circulation of antiphospholipid antibodies (40.9%) is revealed. Conclusion. In the program of preparation for IVF of patients with unsuccessful attempts it is necessary to consider possible presence of the genetic and acquired thrombophilia.

About the Author

T. Y. Mashkova
First MGMU them IM Setchenov
Russian Federation
graduate student of the department of obstetrics and gynecology medical-prophylactic faculty


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For citation:


Mashkova T.Y. THROMBOPHILIA AND FAILURES OF EXTRACORPORAL FERTILIZATION. Obstetrics, Gynecology and Reproduction. 2015;9(3):17-21. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.3.017-021

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)