PREVALENCE OF THROMBOPHILIC POLYMORPHISMS IN WOMEN WITH RECCURENT MISCARRIAGE
https://doi.org/10.17749/2070-4968.2015.9.2.013-018
Abstract
Objective: to study the prevalence of polymorphisms of the coagulation system genes and folate cycle in women with recurrent miscarriage (having two or more reproductive losses. Materials and methods. Carried out of molecular genetic study of 57 women with recurrent miscarriage and 35 patients without reproductive loss and having a history of at least one normally progressing pregnancy, culminating in the birth of a healthy term baby. Results. we have revealed a high incidence of MTHFR C677T, MTRR A66G, FGB G455A, ITGB3 T1565С gene polymorphisms. Conclusion. To prevent repeated reproductive losses in patients with an anamnesis of miscarriage, when other reasons are excluded, it is necessary to conduct a study of gene polymorphisms of coagulation system and folate cycle.
About the Authors
I. O. Bushtyreva
Rostov-on-Don State Medical University of Ministry of Health of Russia, Rostov-on-Don
Russian Federation
MD, Professor, Head of the Department of Obstetrics, Gynecology and Reproduction
Russian Federation
MD, Professor, Head of the Department of Obstetrics, Gynecology and Reproduction
N. B. Kuznetsova
Rostov-on-Don State Medical University of Ministry of Health of Russia, Rostov-on-Don
Russian Federation
PhD, assistant professor of Department of Obstetrics, Gynecology and Reproduction
Russian Federation
PhD, assistant professor of Department of Obstetrics, Gynecology and Reproduction
A. V. Kovaleva
State Budget Establishment of Rostov Region “Perinatal Centre”, Rostov-on-Don
Russian Federation
obstetrician-gynecologist
Russian Federation
obstetrician-gynecologist
V. V. Barinova
State Budget Establishment of Rostov Region “Perinatal Centre”, Rostov-on-Don
Russian Federation
obstetrician-gynecologist
Russian Federation
obstetrician-gynecologist
A. G. Sundeeva
State Budget Establishment of Rostov Region “Perinatal Centre”, Rostov-on-Don
Russian Federation
doctor of Clinical Laboratory,
Russian Federation
doctor of Clinical Laboratory,
References
1. Ailamazyan E.K., Kulakov V.I., Radzinskii V.E., Savel'eva G.M. Obstetrics. national leadership [Akusherstvo. Natsional’noe rukovodstvo]. Moscow. 2013; 1200.
2. Dzhobava E.M., Nekrasova K.R., Artizanova D.P. Akusherstvo, ginekologiya i reproduktsiya/ Obstetrics, gynecology and reproduction. 2013; 1: 45-53.
3. Makatsariya A.D. Thrombohemorrhagic complications in obstetric practice: a guide for physicians [Trombogemorragicheskie oslozhneniya v akushersko-ginekologicheskoi praktike: rukovodstvo dlya vrachei]. Moscow. 2011; 1056.
4. Makatsariya A.D., Panfilova O.Yu. Prakticheskaya meditsina. 2010; 4 (43): 25-37.
5. Putilova N.V. Pathogenetic basis of forecasting and prevention of adverse perinatal outcomes in patients with congenital and acquired thrombophilia Dr. diss. [Patogeneticheskie osnovy prognozirovaniya i profilaktiki neblagopriyatnykh perinatal’nykh iskhodov u patsientok s vrozhdennoi i priobretennoi trombofiliei. Doct. diss]. Chelyabinsk. 2011; 47 s.
6. Sidel’nikova V.M., Sukhikh G.T. Incomplete pregnancy [Nevynashivanie beremennosti]. Moscow. 2010; 536.
7. Bates S.M. Consultative hematology: the pregnant patient pregnancy loss. Hematology Am Soc Hematol Educ Program. 2010; 10: 166-72.
8. Boots C., Stephenson M.D. Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review. Semi. Reprod Med. 2011; 29 (6): 507-13.
9. Carbone J.F., Rampersad R. Prenatal screening for thrombophilias: indications and controversies. Clin Lab Med. 2010; 30 (3): 746-60.
10. Carp H.J., Selmi C., Shoenfeld Y. The autoimmune bases of infertility and pregnancy loss. J Autoimmun. 2012; 38: 2-3.
11. Flynn H., Yan J., Saravelos S.H., Li T.C. Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages. J Obstet Gynaecol Res. 2014; 40 (1): 109-16.
12. Habibovic Z., Zeybek B., Sanhal C., Eroglu Z., Karaca E., Ulukus M. Effects of inherited thrombophilia in women with recurrent pregnancy loss. Clin Exp Obstet Gynecol. 2011; 38 (4): 347-50.
13.
14.
Review
For citations:
Bushtyreva I.O., Kuznetsova N.B., Kovaleva A.V., Barinova V.V., Sundeeva A.G. PREVALENCE OF THROMBOPHILIC POLYMORPHISMS IN WOMEN WITH RECCURENT MISCARRIAGE. Obstetrics, Gynecology and Reproduction. 2015;9(2):13-18. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.2.013-018
Views: 491
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
